Wyoming Sensory Biology COBRE

摘要 怀俄明州感官生物学COBRE（SBC）的主要使命是培养和进行 高质量的科学研究，促进我们的感官系统的理解， 与之相关的疾病。SBC将通过增强和 加强UW的机构生物医学研究能力。这将是完成 通过建立一个临界质量的研究人员，他们的研究兴趣集中在感官 在分子、细胞、生理和系统水平上的过程。SBC将促进 通过提供辅导、培训、协作和培训， 研究支持。SBC将由PI在一个优秀的额外团队的帮助下领导， 导师PI是一个成熟的感觉系统调查员，其专业知识与以下方面密切相关： 该中心的研究主题，有一个活跃的研究实验室，已获得同行评审 他拥有丰富的行政领导和指导经验。SBC是 包括管理核心、集成显微镜核心（IMcore）和四个 相关的研究项目。作为一个整体，SBC将支持四名新的初级调查员， 在COBRE的五年中，将有四名未来的教师受聘于SBC 经费该中心将由一个多学科的调查人员组成，他们具有跨学科的专业知识。 多种感觉形式，包括躯体感觉、化学感觉和视觉。的SBC 研究人员的研究组合显示出基础研究和转化研究的平衡 跨多个领域。SBC的五年目标如下：1。建立一个多- 学科中心，汇集了在感官的不同领域的专业知识的调查人员 神经科学和实验方法，并促进合作，以解决关键问题， 感觉功能和功能障碍。2.支持初级调查员的项目， 强有力的辅导和指导，帮助他们获得独立的资金和专业 成功3.通过招聘新的教师，在规模和范围上扩大SBC， 机构承诺中所描述的，并促进多学科研究， 目前的UW教师，分别。4.通过扩大所需的研究基础设施 显微镜核心的能力。5.提高我们对发展的认识， 感觉系统的功能及其功能障碍。该中心的成功运作是 预计在供资的最初五年内实现以下里程碑： 扩建最先进的成像和显微镜核心设施，所有四个项目负责人 成功竞争R 01级资金;增加了4到6名新的或早期的研究人员 增加了2到4名新的导师（包括最近毕业的项目负责人 从COBRE支持）;和至少20个手稿接受出版或出版在 同行评审的期刊

Abstract The primary mission of the Wyoming Sensory Biology COBRE (SBC) is to foster and conduct high-quality scientific research that advances the understanding of our sensory systems and disorders related to them. SBC will accomplish its mission through the augmentation and strengthening of UW's institutional biomedical research capacity. This will be accomplished through building a critical mass of investigators whose research interests center around sensory processes at the molecular, cellular, physiological and system levels. SBC will promote the competitiveness of the core investigators by providing mentoring, training, collaboration and research support. The SBC will be led by the PI with the help of an excellent group of additional mentors. The PI is an established sensory system investigator with expertise that is germane to the research theme of the center, has an active research laboratory, has obtained peer-reviewed funding and has extensive administrative leadership and mentoring experience. The SBC is comprised of the Administration Core, the Integrated Microscopy Core (IMcore), and four interrelated research projects. As a whole, the SBC will support four new junior investigators and four future faculty hires that are committed to the SBC, during the five years of the COBRE funding. The Center will comprise a multi-disciplinary team of investigators with expertise across multiple sensory modalities, including somatosensation, chemosensation, and vision. The SBC investigators' research portfolios demonstrate a balance of basic and translational research across multiple fields. The five-year goals of the SBC are the following: 1. Establish a multi- disciplinary center that brings together investigators with expertise in diverse areas of sensory neuroscience and experimental methodology, and fosters collaborations to address key issues in sensory function and dysfunction. 2. Support the projects of junior investigators by providing strong mentoring and guidance to help them obtain independent funding and professional success. 3. Grow the SBC in both size and scope through the recruitment of new faculty, as described in the Institutional Commitment, and fostering multi-disciplinary research among current UW faculty, respectively. 4. Build the required research infrastructure by expanding the capabilities of the Microscopy Core. 5. Advance our understanding of the development and function of sensory systems and their dysfunctions. Successful operation of the Center is expected to achieve the following milestones within the initial five years of funding: successful expansion of a state-of-the-art imaging and microscopy core facility, all four Project Leaders successfully competing for R01-level funding; four to six new or early-stage investigators added to the Center; two to four new mentors added (including Project Leaders who recently graduated from COBRE support); and at least 20 manuscripts accepted for publication or published in reputable peer-reviewed journals.