Wyoming Sensory Biology COBRE

摘要 怀俄明州感觉生物学眼镜蛇(SBC)的主要任务是培育和引导 高质量的科学研究，促进对我们感官系统和 与他们相关的疾病。SBC将通过扩容和 加强威斯康星大学的机构生物医学研究能力。这将会实现的 通过建立一批研究兴趣集中在感官上的研究人员 在分子、细胞、生理和系统水平上的过程。SBC将推动 通过提供指导、培训、协作和 研究支持。SBC将由PI领导，并由一组优秀的 导师。PI是一名成熟的感觉系统调查员，其专业知识与 该中心的研究主题，拥有活跃的研究实验室，已获得同行评审 并拥有丰富的行政领导和指导经验。SBC是 由管理核心、集成显微镜核心(IMcore)和四个 相互关联的研究项目。作为一个整体，SBC将支持四名新的初级调查人员和 在科布雷的五年中，承诺为SBC工作的四名未来教职员工 资金问题。该中心将组成一个由多学科调查人员组成的团队，他们拥有跨领域的专业知识 多种感觉模式，包括躯体感觉、化学感觉和视觉。SBC 研究人员的研究组合展示了基础研究和翻译研究的平衡 跨越多个领域。SBC的五年目标如下：1.建立一个多层次的 纪律中心，汇集了在不同感官领域拥有专业知识的调查人员 神经科学和实验方法论，并促进合作，以解决 感觉功能和功能障碍。2.支持初级调查人员的项目，提供 强有力的指导和指导，帮助他们获得独立的资金和专业的 成功。3.通过招聘新的教员，扩大SBC的规模和范围，如 在机构承诺中进行了描述，并在 现任威斯康星州大学教职员工。4.通过扩展 显微镜核心的能力。5.增进对发展和发展的认识 感觉系统的功能及其功能障碍。该中心的成功运营是 预计在筹资的最初五年内实现以下里程碑：成功 扩建最先进的成像和显微镜核心设施，所有四个项目负责人 成功竞争R01级资金；四到六名新的或早期调查人员补充说 到中心；增加了两到四名新导师(包括最近毕业的项目负责人 来自Cobre Support)；至少20篇手稿接受出版或在 声誉良好的同行评议期刊。

Abstract The primary mission of the Wyoming Sensory Biology COBRE (SBC) is to foster and conduct high-quality scientific research that advances the understanding of our sensory systems and disorders related to them. SBC will accomplish its mission through the augmentation and strengthening of UW's institutional biomedical research capacity. This will be accomplished through building a critical mass of investigators whose research interests center around sensory processes at the molecular, cellular, physiological and system levels. SBC will promote the competitiveness of the core investigators by providing mentoring, training, collaboration and research support. The SBC will be led by the PI with the help of an excellent group of additional mentors. The PI is an established sensory system investigator with expertise that is germane to the research theme of the center, has an active research laboratory, has obtained peer-reviewed funding and has extensive administrative leadership and mentoring experience. The SBC is comprised of the Administration Core, the Integrated Microscopy Core (IMcore), and four interrelated research projects. As a whole, the SBC will support four new junior investigators and four future faculty hires that are committed to the SBC, during the five years of the COBRE funding. The Center will comprise a multi-disciplinary team of investigators with expertise across multiple sensory modalities, including somatosensation, chemosensation, and vision. The SBC investigators' research portfolios demonstrate a balance of basic and translational research across multiple fields. The five-year goals of the SBC are the following: 1. Establish a multi- disciplinary center that brings together investigators with expertise in diverse areas of sensory neuroscience and experimental methodology, and fosters collaborations to address key issues in sensory function and dysfunction. 2. Support the projects of junior investigators by providing strong mentoring and guidance to help them obtain independent funding and professional success. 3. Grow the SBC in both size and scope through the recruitment of new faculty, as described in the Institutional Commitment, and fostering multi-disciplinary research among current UW faculty, respectively. 4. Build the required research infrastructure by expanding the capabilities of the Microscopy Core. 5. Advance our understanding of the development and function of sensory systems and their dysfunctions. Successful operation of the Center is expected to achieve the following milestones within the initial five years of funding: successful expansion of a state-of-the-art imaging and microscopy core facility, all four Project Leaders successfully competing for R01-level funding; four to six new or early-stage investigators added to the Center; two to four new mentors added (including Project Leaders who recently graduated from COBRE support); and at least 20 manuscripts accepted for publication or published in reputable peer-reviewed journals.