Wyoming Sensory Biology COBRE

摘要 感官生物学中心(SBC)的主要使命是培养和开展高质量的科学 促进我们对人类感觉系统及其相关障碍的理解的研究。一位少校 该中心的作用是支持和指导初级调查人员的发展，以从事 感觉系统功能和功能障碍。在第一阶段，SBC带头进行了 感觉生物学研究概况。除了与基本机制相关的基础研究外， 关于感觉处理和感觉系统在社会和认知行为中的作用，SBC实验室还 专注于心理健康和精神障碍方面的翻译研究。对于第二阶段，SBC 将在21世纪继续解决与怀俄明州有关的最关键的公共卫生问题 世纪，包括老龄化和慢性病以及阿尔茨海默病和相关疾病 痴呆(AD/RD)、肌萎缩侧索硬化症(ALS)、影响沟通的发育障碍 和儿童的行为(自闭症谱系障碍，ASD)，以及脊髓损伤(SCI)的康复。这个 第二阶段中心将支持四名初始项目负责人，他们将研究新电路在 神经紊乱：臂旁外侧核在与AD/RD相关的日落中的作用； 内侧前额叶皮质在肌萎缩侧索硬化症和AD/RD中的作用；催产素神经元在小细胞核中的作用 在ASD中的亲社会行为和社会行为的扰乱中；以及驱动 炎症和神经胶质细胞在脊髓损伤后恢复过程中的桥联作用。SBC将提高研究质量和产量 初级调查人员通过提供指导、协作和培训以及共享资源和动物 模特们。SBC第二阶段目标的成功执行将有助于推动SBC进入第三阶段 将成为一个独立、蓬勃发展和可持续发展的卓越中心，由超过15人组成 独立资助的实验室和多学科生物医学研究计划。为了实现这一目标，我们 为第二阶段提出以下四个具体目标：目标1.扩大研究范围 与怀俄明州有关的重要健康问题。目标2.通过提供以下服务推进二期中心 对研究、财务、指导和评估活动进行更有效的行政监督。目标3. 提高核心业务的运作效率和长期自我维持能力。目标4.促进经济增长 在第一阶段通过利用第二阶段的财政资源招聘新的初级调查员和 加大对专题节目的融入力度。第二阶段的支持对我们建设 怀俄明州可持续发展研究中心。第二阶段的支持将获得机构 需要为该中心的长期自我维持提供支持，为该中心提供创意后资金。

Abstract The primary mission of the Sensory Biology COBRE (SBC) is to foster and conduct high-quality scientific research that advances our understanding of human sensory systems and disorders related to them. A major role of the Center is to support and mentor the development of junior investigators to pursue research in sensory system function and dysfunction. During Phase I, the SBC spearheaded transformative changes in the landscape of Sensory Biology Research. In addition to basic research related to the fundamental mechanisms of sensory processing and the role of the sensory system in social and cognitive behaviors, SBC labs also focused on translational research in mental health and psychiatric disorders. For the Phase II period, the SBC will continue to tackle the most critical public health issues relevant to the State of Wyoming for the 21st century, including aging and chronic diseases and conditions such as Alzheimer’s disease and related dementias (AD/RD), amyotrophic lateral sclerosis (ALS), developmental disorders that affect communication and behavior in children (autism spectrum disorders, ASD), and recovery from spinal cord injury (SCI). The Phase II Center will support four initial project leaders who will study the key roles of novel circuits in neurological disorders: the role of the lateral parabrachial nucleus in sundowning associated with AD/RD; the role of the medial prefrontal cortex in ALS and AD/RD; the role of oxytocin neurons in the parvocellular nucleus in pro-social behavior and disruptions of social behavior in ASD; and the role of electrical signaling that drives inflammation and glia bridging in the recovery from SCI. SBC will enhance the research quality and output of the junior investigators by providing mentoring, collaboration, and training and by sharing resources and animal models. The successful execution of SBC’s Phase II goal will help propel the SBC into Phase III where SBC will become an independent, thriving, and sustainable Center of Excellence, comprised of over fifteen independently funded labs and a multi-disciplinary biomedical research program. To achieve this goal, we propose the following four specific aims for the Phase II period: Aim 1. Expand the research scope to tackle important health issues relevant to the State of Wyoming. Aim 2. Advance the Phase II center by providing more effective administrative oversight of the research, finance, mentoring, and evaluation activities. Aim 3. Enhance the operational efficiency and the long-term self-sustainability of the Core. Aim 4. Bolster the growth achieved during Phase I by leveraging Phase II financial resources to recruit new junior investigators and increase their integration into thematic programs. Support of Phase II is crucial to our efforts in building a sustainable research center in the State of Wyoming. The support of Phase II will garner the institutional support needed for the long-term self-sustainability of the Center post-IDeA funding.