Wyoming Sensory Biology COBRE

摘要 感官生物学COBRE（SBC）的主要使命是培养和进行高质量的科学研究， 促进我们对人类感觉系统及其相关疾病的理解的研究。一个主要 该中心的作用是支持和指导初级研究人员的发展， 感觉系统功能和功能障碍。在第一阶段，SBC率先在 感官生物学研究的景观。除了与基本机制相关的基础研究外， 感觉处理和感觉系统在社会和认知行为中的作用，SBC实验室还 专注于心理健康和精神疾病的转化研究。在第二阶段，SBC 将在21日继续解决与怀俄明州有关的最关键的公共卫生问题 世纪，包括衰老和慢性疾病和病症，如阿尔茨海默病和相关的 痴呆（AD/RD）、肌萎缩侧索硬化（ALS）、影响交流的发育障碍 和行为（自闭症谱系障碍，ASD），以及脊髓损伤（SCI）的恢复。的 第二阶段中心将支持四个最初的项目负责人，他们将研究新电路的关键作用， 神经系统疾病：臂旁外侧核在与AD/RD相关的日落中的作用; 内侧前额叶皮质在ALS和AD/RD中的作用;小细胞核中催产素神经元的作用 在ASD中的亲社会行为和社会行为的破坏中的作用;以及驱动ASD的电信号的作用。 炎症和胶质桥接在SCI恢复中的作用。SBC将提高研究质量和产出， 通过提供指导、合作和培训以及共享资源和动物， 模型SBC第二阶段目标的成功执行将有助于推动SBC进入第三阶段， 将成为一个独立的，蓬勃发展的，可持续发展的卓越中心，由超过15个 独立资助的实验室和多学科生物医学研究计划。为了实现这一目标，我们 为第二阶段提出以下四个具体目标：目标1。扩大研究范围， 与怀俄明州有关的重要健康问题。目标二。推进二期中心， 对研究、财务、指导和评估活动进行更有效的行政监督。目标3。 提高核心的运营效率和长期自我维持能力。目标4。促进增长 通过利用第二阶段的财政资源征聘新的初级调查员， 加强与专题方案的结合。第二阶段的支持对我们建立一个 位于怀俄明州的可持续发展研究中心。第二阶段的支持将获得机构的支持， 为中心在IDEA后供资的长期自我可持续性提供所需的支持。

Abstract The primary mission of the Sensory Biology COBRE (SBC) is to foster and conduct high-quality scientific research that advances our understanding of human sensory systems and disorders related to them. A major role of the Center is to support and mentor the development of junior investigators to pursue research in sensory system function and dysfunction. During Phase I, the SBC spearheaded transformative changes in the landscape of Sensory Biology Research. In addition to basic research related to the fundamental mechanisms of sensory processing and the role of the sensory system in social and cognitive behaviors, SBC labs also focused on translational research in mental health and psychiatric disorders. For the Phase II period, the SBC will continue to tackle the most critical public health issues relevant to the State of Wyoming for the 21st century, including aging and chronic diseases and conditions such as Alzheimer’s disease and related dementias (AD/RD), amyotrophic lateral sclerosis (ALS), developmental disorders that affect communication and behavior in children (autism spectrum disorders, ASD), and recovery from spinal cord injury (SCI). The Phase II Center will support four initial project leaders who will study the key roles of novel circuits in neurological disorders: the role of the lateral parabrachial nucleus in sundowning associated with AD/RD; the role of the medial prefrontal cortex in ALS and AD/RD; the role of oxytocin neurons in the parvocellular nucleus in pro-social behavior and disruptions of social behavior in ASD; and the role of electrical signaling that drives inflammation and glia bridging in the recovery from SCI. SBC will enhance the research quality and output of the junior investigators by providing mentoring, collaboration, and training and by sharing resources and animal models. The successful execution of SBC’s Phase II goal will help propel the SBC into Phase III where SBC will become an independent, thriving, and sustainable Center of Excellence, comprised of over fifteen independently funded labs and a multi-disciplinary biomedical research program. To achieve this goal, we propose the following four specific aims for the Phase II period: Aim 1. Expand the research scope to tackle important health issues relevant to the State of Wyoming. Aim 2. Advance the Phase II center by providing more effective administrative oversight of the research, finance, mentoring, and evaluation activities. Aim 3. Enhance the operational efficiency and the long-term self-sustainability of the Core. Aim 4. Bolster the growth achieved during Phase I by leveraging Phase II financial resources to recruit new junior investigators and increase their integration into thematic programs. Support of Phase II is crucial to our efforts in building a sustainable research center in the State of Wyoming. The support of Phase II will garner the institutional support needed for the long-term self-sustainability of the Center post-IDeA funding.