Wyoming Sensory Biology COBRE

摘要 感官生物学 COBRE (SBC) 的主要使命是培养和开展高质量的科学研究 增进我们对人类感觉系统及其相关疾病的理解的研究。一个专业 该中心的作用是支持和指导初级研究人员的发展，以从事以下领域的研究 感觉系统功能和功能障碍。在第一阶段，SBC 率先在 感觉生物学研究的景观。除了与基本机制相关的基础研究 SBC 实验室还研究了感觉处理以及感觉系统在社会和认知行为中的作用 专注于心理健康和精神疾病的转化研究。对于第二阶段期间，SBC 将在 21 日继续解决与怀俄明州相关的最关键的公共卫生问题 世纪，包括衰老和慢性疾病和病症，例如阿尔茨海默病和相关疾病 痴呆症 (AD/RD)、肌萎缩侧索硬化症 (ALS)、影响沟通的发育障碍 儿童行为（自闭症谱系障碍，ASD），以及脊髓损伤（SCI）的恢复。的 第二阶段中心将支持四名初始项目负责人，他们将研究新型电路在 神经系统疾病：臂旁外侧核在与 AD/RD 相关的日落中的作用；的 内侧前额叶皮层在 ALS 和 AD/RD 中的作用；小细胞核中催产素神经元的作用 自闭症谱系障碍 (ASD) 中的亲社会行为和社会行为破坏；以及驱动电信号的作用 SCI 恢复过程中的炎症和神经胶质细胞桥接。 SBC将提高研究质量和产出 通过提供指导、协作和培训以及共享资源和动物来帮助初级研究人员 模型。 SBC第二阶段目标的成功执行将有助于推动SBC进入第三阶段，其中SBC 将成为一个独立、蓬勃发展、可持续发展的卓越中心，由超过 15 名成员组成 独立资助的实验室和多学科生物医学研究项目。为了实现这一目标，我们 提出第二阶段的以下四个具体目标： 目标 1. 扩大研究范围，解决 与怀俄明州相关的重要健康问题。目标 2. 通过提供 对研究、财务、指导和评估活动进行更有效的行政监督。目标3。 提高核心的运营效率和长期自我可持续性。目标 4. 促进增长 通过利用第二阶段的财务资源招募新的初级研究人员和 加强其与专题计划的融合。二期工程的支持对于我们建设 怀俄明州可持续发展研究中心。第二阶段的支持将获得机构的支持 该中心在 IDeA 后资金的长期自我维持所需的支持。

Abstract The primary mission of the Sensory Biology COBRE (SBC) is to foster and conduct high-quality scientific research that advances our understanding of human sensory systems and disorders related to them. A major role of the Center is to support and mentor the development of junior investigators to pursue research in sensory system function and dysfunction. During Phase I, the SBC spearheaded transformative changes in the landscape of Sensory Biology Research. In addition to basic research related to the fundamental mechanisms of sensory processing and the role of the sensory system in social and cognitive behaviors, SBC labs also focused on translational research in mental health and psychiatric disorders. For the Phase II period, the SBC will continue to tackle the most critical public health issues relevant to the State of Wyoming for the 21st century, including aging and chronic diseases and conditions such as Alzheimer’s disease and related dementias (AD/RD), amyotrophic lateral sclerosis (ALS), developmental disorders that affect communication and behavior in children (autism spectrum disorders, ASD), and recovery from spinal cord injury (SCI). The Phase II Center will support four initial project leaders who will study the key roles of novel circuits in neurological disorders: the role of the lateral parabrachial nucleus in sundowning associated with AD/RD; the role of the medial prefrontal cortex in ALS and AD/RD; the role of oxytocin neurons in the parvocellular nucleus in pro-social behavior and disruptions of social behavior in ASD; and the role of electrical signaling that drives inflammation and glia bridging in the recovery from SCI. SBC will enhance the research quality and output of the junior investigators by providing mentoring, collaboration, and training and by sharing resources and animal models. The successful execution of SBC’s Phase II goal will help propel the SBC into Phase III where SBC will become an independent, thriving, and sustainable Center of Excellence, comprised of over fifteen independently funded labs and a multi-disciplinary biomedical research program. To achieve this goal, we propose the following four specific aims for the Phase II period: Aim 1. Expand the research scope to tackle important health issues relevant to the State of Wyoming. Aim 2. Advance the Phase II center by providing more effective administrative oversight of the research, finance, mentoring, and evaluation activities. Aim 3. Enhance the operational efficiency and the long-term self-sustainability of the Core. Aim 4. Bolster the growth achieved during Phase I by leveraging Phase II financial resources to recruit new junior investigators and increase their integration into thematic programs. Support of Phase II is crucial to our efforts in building a sustainable research center in the State of Wyoming. The support of Phase II will garner the institutional support needed for the long-term self-sustainability of the Center post-IDeA funding.