2021 Wnt Signaling GRC/GRS

项目摘要 我们请求部分支持戈登研究会议（GRC）和戈登研究研讨会（GRS） 题为“Wnt信号传导：分子机制，发展和组织稳态，和治疗”， 2021年8月1日至6日在西班牙Castelldefels的Rey Don Jaime Grand Hotel举行。本次会议将由 作者：Stephane昂热（加拿大多伦多大学）和Mariann Bienz（英国MRC）与Ken Cadigan （美国密歇根大学）和Madelon Maurice（荷兰UMC乌得勒支）担任副主席。并将包括 来自许多杰出科学家的演讲，在不同的职业生涯阶段，活跃在Wnt生物学领域。的 GRS将于2021年7月31日至8月1日在同一地点举行，并将邀请即将毕业的毕业生参加讲座 学生和博士后研究员，并将由博士后研究员罗尼奇迪亚克（多伦多大学） 和Pooja R. Sonavane（USCD）.会议的具体目的是提供一个论坛， 并讨论了Wnt生物学各个方面的最新进展和新思想。这一领域的进展 不断加速，并触及了所有后生动物生命形式中的无数生物过程。在 此外，Wnt途径被广泛认为是组织稳态的关键调节剂，因此， 它的失调与许多疾病有关，从早期发育异常到年龄相关的 疾病，如癌症。 会议主题是根据其对当前关键科学问题的潜在影响而选择的 在发育、干细胞生物学和癌症方面。会议的安排包括关于机制的会议 Wnt信号转导的结构与功能，Wnt信号在组织工程中的作用， 类器官，疾病中的Wnt信号传导，发育中的Wnt信号传导，不依赖于bcatenin的Wnt信号传导， 干细胞中的信号传导、组织稳态和再生以及Wnt信号传导的治疗靶向。见解 Wnt功能将从广泛的模式生物中收集，包括水螅，蠕虫，苍蝇， 青蛙、鱼和老鼠。与会科学家的多样性沿着广泛的议题 将不仅提供一个肥沃的学习环境，肯定会有利于所有与会者，但也将导致 新的见解，互动和未来的合作，将推动生物医学研究的边界。 本研究的主要长期目标是提高我们对这一复杂而关键的信号通路的理解 从而有助于靶向和操纵该途径的方法的持续发展， 目前无法治愈的疾病的最终治疗干预。

Project Summary We request partial support for the Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) titled ““Wnt Signaling: Molecular Mechanisms, Development andTtissue Homeostasis, and Therapeutics” to be held August 1-6, 2021 at the Rey Don Jaime Grand Hotel in Castelldefels, Spain. This meeting will be chaired by Stephane Angers (University of Toronto, Canada) and Mariann Bienz (MRC, UK) with Ken Cadigan (University of Michigan, USA) and Madelon Maurice (UMC Utrecht, Netherlands) as Vice-Chairs., and will include presentations from many prominent scientists, at varied career stages, active in the field of Wnt biology. The GRS will be held at the same location July 31-August 1, 2021 and will feature talks from up and coming graduate students and postdoctoral fellows and will be led by postdoctoral fellows Rony Chidiac (University of Toronto) and Pooja R. Sonavane (USCD). The specific aim of the conference is to provide a forum for the presentation and discussion of recent advances and new ideas in all aspects of Wnt biology. Progress in this field has consistently accelerated and has touched on countless biological processes in all metazoan life forms. In addition, the Wnt pathway is widely recognized as a critical regulator of tissue homeostasis, and, consequently, its de-regulation is associated with many disorders, from early developmental abnormalities to age-related diseases, such as cancer. Session topics have been selected on the basis of their potential impact on the key current scientific questions in development, stem cell biology and cancer. The meeting is structured to include sessions on the mechanisms of Wnt signal transduction, structure and function of Wnt signaling, Wnt signaling in tissue engineering and organoids, Wnt signaling in diseases, Wnt signaling in Development, bcatenin-independent Wnt signaling, Wnt signaling in stem cells, tissue homeostasis and regeneration and Therapeutic targeting of Wnt signaling. Insights into the Wnt function will be gleaned from a broad spectrum of model organisms, including hydra, worms, flies, frogs, fish and mice. The diversity of scientists gathering at this meeting along with the broad spectrum of topics will not only provide a fertile learning environment that will certainly benefit all attendees, but will also lead to new insights, interactions and future collaborations that will push the boundaries of biomedical research. The main long-term goal of this GRC is to raise our understanding of this complex and critical signaling pathway and thereby contribute to the continuous development of methods to target and manipulate this pathway for eventual therapeutic interventions of currently incurable diseases.