RR&D Research Career Scientist Award Application

彭定康博士的研究重点是了解人类运动的神经基础。首要目标是 她的翻译研究的主要目的是通过开发 有效、高效、有针对性的干预措施，促进神经运动功能的恢复。消息来源广泛 作为一名物理治疗师的临床经验，她的研究沟通了神经康复领域， 神经力学和神经工程学要进行定量、力学研究，与三个相关 目的：1)阐明随年龄增长的运动功能障碍的机制和成人神经病理学；2) 确定中枢神经系统损伤后的运动恢复能力；以及3)确定关键的 影响康复疗效的因素。为了实现这些目标，她的纲领路线 研究调查：a)中枢神经系统病理导致的神经机制和生物力学后果 运动功能障碍，b)运动恢复的生物标志物的发展，以及c)诱导 神经可塑性和运动恢复。彭定康博士的研究影响了神经康复的临床护理，因此 帮助因中风等神经病理导致的运动功能障碍患者最大限度地恢复健康， 恢复活动参与度，优化生活质量。 彭定康博士研究中风相关运动功能障碍的成年人已有20多年。她一直是 四项VA-RRD支持的临床试验的首席研究员调查疗效和对 卒中后患者的康复干预[VA RRD B2450R，VA RRD B29792R，VA RRD B3964R， Va RRD B540231]。这些研究的结果对该领域产生了影响，并已被纳入 临床实践指南和建议，如中风康复的循证审查。 对治疗干预的应答者和无应答者的观察-没有基线差异 临床特征-动机调查这些亚组之间的内在生理差异， 为此，她在慢性中风幸存者的横断面研究中进行了研究(VA RR&D 1I21RX-1435-0)。 这项工作激发了随后的VA RR&D功绩评估(I01RX001677)，目前她作为 PI，以检验掌屈肌皮质脊髓作为步行恢复的潜在生物标志物的有效性。另外， 她是一个多点研究(R01NR015591)的站点PI，跟踪压力和遗传变异的生物标记物 在卒中后的急性期收集，以确定这些信息如何在应对 康复。她还作为Co-I(1R01AG054621-01)合作研究使用高密度脑电来 了解老年人在运动过程中对干扰做出反应的大脑动力学。最后，一项新的研究 由美国国家科学基金会(M3X，#1935501)支持，将使我们能够更深入地了解人类运动的过程 学习，可塑性，并转移到行为，神经机械效应。 目前的申请是续签研究职业科学家对Carolynn Patten博士的支持，他是一名非 临床医生研究员，通过VA康复研发提供了20多年的不间断研究支持 服务。彭定康博士在弗吉尼亚州北加州医疗保健系统之间双重任命(5/8 VA) (VANCHCS)和加州大学戴维斯分校，在那里她是 物理医学与康复(医学院)和神经生物学、生理学与行为学(医学院 生物科学)。2018年7月，彭定康博士过渡到加州大学戴维斯分校和VANCHCS目前的职位 来自马尔科姆·兰德尔医学中心(佛罗里达州盖恩斯维尔)和退伍军人事务部脑康复研究中心 (BRRC)在那里她被MRVAMC/BRRC(6.6/8 VA)和佛罗里达大学双重任命 她在理疗系担任教授(终身教授)。彭定康博士被公认为 2015年，佛罗里达大学研究基金会教授，被选为凯瑟琳·沃辛厄姆 2016年，美国物理治疗协会院士，该行业的最高学术荣誉。

Dr. Patten's research focuses on understanding the neural basis of human movement. The overarching goal of her translational research is to improve the quality of clinical neurorehabilitation through development of effective, efficient, targeted interventions that promote recovery of neuromotor function. Informed by extensive clinical experience as a physical therapist, her research bridges the fields of neurorehabilitation, neuromechanics, and neuroengineering to conduct quantitative, mechanistic investigation with three related objectives: 1) elucidating mechanisms of movement dysfunction with aging and in adult neuropathologies; 2) determining capacity for motor recovery following central nervous system injury; and 3) identifying critical factors that contribute to rehabilitation efficacy. To achieve these goals, the programmatic lines of her research investigate: a) neural mechanisms and biomechanical consequences of CNS pathologies causing motor dysfunction, b) development of biomarkers of motor recovery, and c) novel means to induce neuroplasticity and motor recovery. Dr. Patten's research influences clinical care in neurorehabilitation, thus helps individuals with motor dysfunction resulting from neuropathologies, such as stroke, maximize recovery, restore activity participation, and optimize quality of life. Dr. Patten has studied adults with stroke-related motor dysfunction for over 20 years. She has been the Principal Investigator for four VA-RRD supported clinical trials investigating effects and response to rehabilitation interventions for persons post-stroke [VA RRD B2450R, VA RRD B29792R, VA RRD B3964R, VA RRD B540231]. Results of these studies have been influential for the field and have been incorporated into clinical practice guidelines and recommendations such as the Evidence-based Review of Stroke Rehabilitation. Observation of responders and non-responders to therapeutic intervention —without baseline differences in clinical characteristics— motivated investigation of intrinsic physiological differences among these sub-groups, for which she conducted in cross-sectional studies of chronic stroke survivors (VA RR&D 1I21RX-1435-0]). This work motivated a subsequent VA RR&D Merit Review (I01RX001677), which she currently conducts as PI, to examine plantarflexor corticospinal efficacy as a potential biomarker for walking recovery. Additionally, she is the Site PI for a multi-site study (R01NR015591) tracking biomarkers of stress and genetic variation collected in the acute period following stroke to determine how these may inform heterogeneity in response to rehabilitation. She also collaborates, as a Co-I (1R01AG054621-01) on studies using high-density EEG to understand brain dynamics in elders in response to perturbations during locomotion. Finally, a new study supported by the NSF (M3X, #1935501) will enable deeper understanding of the process of human motor learning, plasticity, and transfer to behavioral, neuromechanical effects. The current application is for renewal of Research Career Scientist support to Dr. Carolynn Patten, a non- clinician Investigator, with over 20 years of uninterrupted research support through the VA Rehabilitation R&D service. Dr. Patten is dual-appointed (5/8 VA) between VA Northern California Health Care System (VANCHCS) and University of California, Davis, where she is a Professor (tenured) in the Departments of Physical Medicine & Rehabilitation (School of Medicine) and Neurobiology, Physiology & Behavior (College of Biological Sciences). In July 2018 Dr. Patten transitioned to her current position at UC Davis and VANCHCS from Malcom Randall VA Medical Center (Gainesville, FL) and VA Brain Rehabilitation Research Center (BRRC) where she was dual-appointed between MRVAMC / BRRC (6.6/8 VA) and University of Florida where she held the rank of Professor (tenured) in the Department of Physical Therapy. Dr. Patten was recognized as a University of Florida Research Foundation Professor in 2015 and was inducted as Catherine Worthingham Fellow of the American Physical Therapy Association, the profession's highest academic honor, in 2016.