RR&D Research Career Scientist Award Application

Patten博士的研究重点是了解人类运动的神经基础。总体目标 她的转化研究是通过发展临床神经康复的质量， 有效、高效、有针对性的干预措施，促进神经运动功能的恢复。由广泛的 作为一名物理治疗师的临床经验，她的研究桥接了神经康复领域， 神经力学和神经工程进行定量，机械调查与三个相关的 目的：1）阐明运动功能障碍与衰老和成人神经病理学的机制; 2） 确定中枢神经系统损伤后运动恢复的能力;以及3）确定关键的 影响康复效果的因素。为了实现这些目标，她的纲领性路线 研究调查：a）中枢神经系统病理的神经机制和生物力学后果， 运动功能障碍，B）运动恢复的生物标志物的开发，和c）诱导运动障碍的新方法， 神经可塑性和运动恢复。Patten博士的研究影响了神经康复的临床护理， 帮助患有神经病理学（如中风）导致的运动功能障碍的个体，最大限度地恢复， 恢复活动参与，优化生活质量。 博士Patten研究中风相关运动功能障碍的成年人超过20年。她一直是 四项VA-RRD的主要研究者支持临床试验，研究对以下药物的影响和反应： 卒中后患者的康复干预[VA RRD B2450 R，VA RRD B29792 R，VA RRD B3964 R， VA RRD B540231]。这些研究的结果对该领域具有影响力，并已被纳入 临床实践指南和建议，如中风康复循证综述。 观察治疗干预的应答者和非应答者-无基线差异 临床特征-这些亚组之间内在生理差异的动机性研究， 为此，她进行了慢性卒中幸存者的横断面研究（VA RR&D 1 I21 RX-1435-0）。 这项工作激发了随后的VA RR&D Merit Review（I 01 RX 001677），她目前正在进行， PI，检查跖屈肌皮质脊髓功能作为步行恢复的潜在生物标志物的疗效。此外，本发明还 她是一项多中心研究（R 01 NR 015591）的研究中心PI，该研究跟踪压力和遗传变异的生物标志物 在卒中后急性期收集，以确定这些信息如何反映 康复活动.她还以Co-I（1 R 01 AG 054621 -01）的身份参与使用高密度EEG的研究， 了解老年人在运动过程中对扰动的大脑动力学反应。最后，一项新的研究 由NSF（M3 X，#1935501）支持，将使人们能够更深入地了解人类运动的过程 学习，可塑性，以及转移到行为，神经机械效应。 目前的申请是为了更新研究职业科学家的支持博士卡罗琳彭定康，一个非 临床研究者，通过VA康复研发提供超过20年的不间断研究支持 的服务. Patten博士是VA北方加州医疗保健系统之间的双重任命（5/8 VA） （VANCHCS）和加州大学戴维斯分校，她是教授（终身）在部门 物理医学与康复（医学院）和神经生物学，生理学与行为（学院） 生物科学）。2018年7月，Patten博士在UC Davis和VANCHCS担任现职 来自马尔科姆兰德尔退伍军人医疗中心（盖恩斯维尔，佛罗里达州）和退伍军人大脑康复研究中心 （BRRC），她在MRVAMC / BRRC（6.6/8 VA）和佛罗里达大学之间双重任命， 她在物理治疗系担任教授（终身）。彭定康博士被公认为 佛罗里达大学研究基金会教授，2015年被任命为凯瑟琳·沃辛厄姆 美国物理治疗协会会员，该行业最高学术荣誉，2016年。

Dr. Patten's research focuses on understanding the neural basis of human movement. The overarching goal of her translational research is to improve the quality of clinical neurorehabilitation through development of effective, efficient, targeted interventions that promote recovery of neuromotor function. Informed by extensive clinical experience as a physical therapist, her research bridges the fields of neurorehabilitation, neuromechanics, and neuroengineering to conduct quantitative, mechanistic investigation with three related objectives: 1) elucidating mechanisms of movement dysfunction with aging and in adult neuropathologies; 2) determining capacity for motor recovery following central nervous system injury; and 3) identifying critical factors that contribute to rehabilitation efficacy. To achieve these goals, the programmatic lines of her research investigate: a) neural mechanisms and biomechanical consequences of CNS pathologies causing motor dysfunction, b) development of biomarkers of motor recovery, and c) novel means to induce neuroplasticity and motor recovery. Dr. Patten's research influences clinical care in neurorehabilitation, thus helps individuals with motor dysfunction resulting from neuropathologies, such as stroke, maximize recovery, restore activity participation, and optimize quality of life. Dr. Patten has studied adults with stroke-related motor dysfunction for over 20 years. She has been the Principal Investigator for four VA-RRD supported clinical trials investigating effects and response to rehabilitation interventions for persons post-stroke [VA RRD B2450R, VA RRD B29792R, VA RRD B3964R, VA RRD B540231]. Results of these studies have been influential for the field and have been incorporated into clinical practice guidelines and recommendations such as the Evidence-based Review of Stroke Rehabilitation. Observation of responders and non-responders to therapeutic intervention —without baseline differences in clinical characteristics— motivated investigation of intrinsic physiological differences among these sub-groups, for which she conducted in cross-sectional studies of chronic stroke survivors (VA RR&D 1I21RX-1435-0]). This work motivated a subsequent VA RR&D Merit Review (I01RX001677), which she currently conducts as PI, to examine plantarflexor corticospinal efficacy as a potential biomarker for walking recovery. Additionally, she is the Site PI for a multi-site study (R01NR015591) tracking biomarkers of stress and genetic variation collected in the acute period following stroke to determine how these may inform heterogeneity in response to rehabilitation. She also collaborates, as a Co-I (1R01AG054621-01) on studies using high-density EEG to understand brain dynamics in elders in response to perturbations during locomotion. Finally, a new study supported by the NSF (M3X, #1935501) will enable deeper understanding of the process of human motor learning, plasticity, and transfer to behavioral, neuromechanical effects. The current application is for renewal of Research Career Scientist support to Dr. Carolynn Patten, a non- clinician Investigator, with over 20 years of uninterrupted research support through the VA Rehabilitation R&D service. Dr. Patten is dual-appointed (5/8 VA) between VA Northern California Health Care System (VANCHCS) and University of California, Davis, where she is a Professor (tenured) in the Departments of Physical Medicine & Rehabilitation (School of Medicine) and Neurobiology, Physiology & Behavior (College of Biological Sciences). In July 2018 Dr. Patten transitioned to her current position at UC Davis and VANCHCS from Malcom Randall VA Medical Center (Gainesville, FL) and VA Brain Rehabilitation Research Center (BRRC) where she was dual-appointed between MRVAMC / BRRC (6.6/8 VA) and University of Florida where she held the rank of Professor (tenured) in the Department of Physical Therapy. Dr. Patten was recognized as a University of Florida Research Foundation Professor in 2015 and was inducted as Catherine Worthingham Fellow of the American Physical Therapy Association, the profession's highest academic honor, in 2016.