RR&D Research Career Scientist Award Application

RR

• 批准号: 10553083
• 负责人: Carolynn Patten
• 金额: --
• 依托单位: VA NORTHERN CALIFORNIA HEALTH CARE SYS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553083
• 关键词: Acute; Adult; Age; Age-Years; Aging; American Physical Therapy Association; Area; Award; Baby Booms; Behavior; Behavioral; Biological Markers; Biological Sciences; Biomechanics; Biomedical Engineering; Brain; Brain Injuries; California; Caring; Characteristics; Clinical; Clinical Medicine; Clinical Practice Guideline; Clinical Trials; Computer Models; Critical Care; Cross-Sectional Studies; Data; Data Reporting; Development; Discipline; Elderly; Electroencephalography; Female; Florida; Foundations; Functional disorder; Future; Gait; Generations; Genetic Variation; Goals; Healthcare; Healthcare Systems; Heterogeneity; Human; Hyperreflexia; Impairment; Individual; Influentials; Intervention; Investigation; Kinetics; Learning; Limb structure; Locomotion; Measures; Medical center; Methods; Motion; Motor; Movement; Nervous system structure; Neurobiology; Neuromechanics; Neuronal Plasticity; Neurosciences; Neurosciences Research; Outcome; Paper; Pathology; Performance; Persons; Physical Medicine; Physical therapy; Physiological; Physiology; Positioning Attribute; Prevalence; Principal Investigator; Process; Production; Prognosis; Quality of life; Recommendation; Recovery; Reflex action; Rehabilitation therapy; Research; Research Personnel; Research Support; Role; Scientist; Seminal; Series; Services; Site; Stress; Stroke; Subgroup; Therapeutic; Therapeutic Intervention; Transcranial magnetic stimulation; Translational Research; Universities; Veterans; Veterans Health Administration; Walking; Work; acute care; age related; biomarker development; career; central nervous system injury; chronic stroke; clinical care; clinical decision-making; cohort; college; cost; density; design; disability; evidence base; experience; fundamental research; improved; inpatient service; kinematics; male; medical schools; motor control; motor disorder; motor impairment; motor learning; motor recovery; neuroimaging; neurological rehabilitation; neuromechanism; neuropathology; neurophysiology; novel; physical therapist; post stroke; potential biomarker; predictive modeling; professor; programs; rehabilitation research; relating to nervous system; remediation; research and development; responders and non-responders; response; statistics; stroke intervention; stroke recovery; stroke rehabilitation; stroke risk; stroke survivor; translational goal; translational neuroscience

Dr. Patten's research focuses on understanding the neural basis of human movement. The overarching goal of her translational research is to improve the quality of clinical neurorehabilitation through development of effective, efficient, targeted interventions that promote recovery of neuromotor function. Informed by extensive clinical experience as a physical therapist, her research bridges the fields of neurorehabilitation, neuromechanics, and neuroengineering to conduct quantitative, mechanistic investigation with three related objectives: 1) elucidating mechanisms of movement dysfunction with aging and in adult neuropathologies; 2) determining capacity for motor recovery following central nervous system injury; and 3) identifying critical factors that contribute to rehabilitation efficacy. To achieve these goals, the programmatic lines of her research investigate: a) neural mechanisms and biomechanical consequences of CNS pathologies causing motor dysfunction, b) development of biomarkers of motor recovery, and c) novel means to induce neuroplasticity and motor recovery. Dr. Patten's research influences clinical care in neurorehabilitation, thus helps individuals with motor dysfunction resulting from neuropathologies, such as stroke, maximize recovery, restore activity participation, and optimize quality of life. Dr. Patten has studied adults with stroke-related motor dysfunction for over 20 years. She has been the Principal Investigator for four VA-RRD supported clinical trials investigating effects and response to rehabilitation interventions for persons post-stroke [VA RRD B2450R, VA RRD B29792R, VA RRD B3964R, VA RRD B540231]. Results of these studies have been influential for the field and have been incorporated into clinical practice guidelines and recommendations such as the Evidence-based Review of Stroke Rehabilitation. Observation of responders and non-responders to therapeutic intervention —without baseline differences in clinical characteristics— motivated investigation of intrinsic physiological differences among these sub-groups, for which she conducted in cross-sectional studies of chronic stroke survivors (VA RR&D 1I21RX-1435-0]). This work motivated a subsequent VA RR&D Merit Review (I01RX001677), which she currently conducts as PI, to examine plantarflexor corticospinal efficacy as a potential biomarker for walking recovery. Additionally, she is the Site PI for a multi-site study (R01NR015591) tracking biomarkers of stress and genetic variation collected in the acute period following stroke to determine how these may inform heterogeneity in response to rehabilitation. She also collaborates, as a Co-I (1R01AG054621-01) on studies using high-density EEG to understand brain dynamics in elders in response to perturbations during locomotion. Finally, a new study supported by the NSF (M3X, #1935501) will enable deeper understanding of the process of human motor learning, plasticity, and transfer to behavioral, neuromechanical effects. The current application is for renewal of Research Career Scientist support to Dr. Carolynn Patten, a non- clinician Investigator, with over 20 years of uninterrupted research support through the VA Rehabilitation R&D service. Dr. Patten is dual-appointed (5/8 VA) between VA Northern California Health Care System (VANCHCS) and University of California, Davis, where she is a Professor (tenured) in the Departments of Physical Medicine & Rehabilitation (School of Medicine) and Neurobiology, Physiology & Behavior (College of Biological Sciences). In July 2018 Dr. Patten transitioned to her current position at UC Davis and VANCHCS from Malcom Randall VA Medical Center (Gainesville, FL) and VA Brain Rehabilitation Research Center (BRRC) where she was dual-appointed between MRVAMC / BRRC (6.6/8 VA) and University of Florida where she held the rank of Professor (tenured) in the Department of Physical Therapy. Dr. Patten was recognized as a University of Florida Research Foundation Professor in 2015 and was inducted as Catherine Worthingham Fellow of the American Physical Therapy Association, the profession's highest academic honor, in 2016.

帕滕博士的研究重点是理解人类运动的神经基础。总体目标 她的翻译研究是通过发展来提高临床神经康复的质量 有效，有效，有针对性的干预措施，促进神经运动功能的恢复。通过广泛告知 作为物理治疗师的临床经验，她的研究使神经康复领域桥接， 神经力学和神经工程技术，以进行定量，机械投资，三个相关 目的：1）阐明运动功能障碍的机制与衰老和成人神经病理学； 2） 确定中枢神经系统损伤后运动恢复的能力； 3）确定关键 有助于康复效率的因素。为了实现这些目标，她的编程路线 研究调查：a）CNS病理的神经机制和生物力学后果 运动功能障碍，b）运动恢复生物标志物的发展，c）诱导新颖的手段 神经可塑性和运动恢复。 Patten博士的研究影响神经康复中的临床护理，因此 帮助由神经病理学（例如中风，最大恢复， 恢复活动参与并优化生活质量。 Patten博士的成年人患有与中风相关的运动功能障碍的成年人，已有20多年的历史了。她一直是 四个VA-RRD的主要研究者支持临床试验，调查效果和对 中风后的康复干预措施[VA RRD B2450R，VA RRD B29792R，VA RRD B3964R， VA RRD B540231]。这些研究的结果对该领域具有影响，并已纳入 临床实践指南和建议，例如对中风康复的循证审查。 观察响应者和对治疗干预的无反应者 - 没有基线差异 临床特征 - 这些亚组之间内在生理差异的动机研究， 她在慢性中风存活率的横断面研究（VA RR＆D 1I21RX-1435-0）中进行了此操作。 这项工作激发了随后的VA RR＆D功绩评论（I01RX001677），她目前正在进行 PI，将plantarflexor皮质脊髓效率作为步行恢复的潜在生物标志物。此外， 她是多站点研究（R01NR015591）的站点PI跟踪压力和遗传变异的生物标志物 在中风后的急性期内收集，以确定这些方式如何告知异质性 康复。她还以高密度脑电为研究的研究还合作，作为CO-I（1R01AG054621-01） 了解长老对运动过程中的扰动的脑动力学。最后，一项新研究 由NSF（M3X，＃1935501）支持，将使人们更深入地了解人类电机的过程 学习，可塑性和转移到行为，神经力学效应。 当前的申请是为了续签研究职业科学家支持Carolynn Patten博士的支持， 临床研究人员，通过VA康复研发，拥有超过20年的不间断研究支持 服务。 Patten博士在VA北加州医疗保健系统之间被双重任命（5/8 VA） （Vanchcs）和加利福尼亚大学戴维斯分校，她是该系的教授（任职） 物理医学与康复（医学院）和神经生物学，生理与行为（学院 生物科学）。 2018年7月，Patten博士过渡到她目前在加州大学戴维斯分校和Vanchcs的职位 来自Malcom Randall VA医疗中心（佛罗里达州盖恩斯维尔）和VA脑康复研究中心 （BRRC）她在MRVAMC / BRRC（6.6 / 8 VA）和佛罗里达大学之间被双重任命 她在物理治疗系任职教授（任期）。帕滕博士被公认为 佛罗里达大学研究基金会的教授于2015年，被归于凯瑟琳·沃辛汉姆（Catherine Worthingham） 2016年，该行业最高学术荣誉的美国物理治疗协会会员。