VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Data and Biostatistics Core

VA-DoD 军事相关脑损伤联盟 (LIMBIC) 的长期影响：数据和生物统计学核心

• 批准号: 10269014
• 负责人: Mary Jo Pugh
• 金额: --
• 依托单位: VA SALT LAKE CITY HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10269014
• 关键词: Academia; Acute; Address; Area; Basic Science; Biological Markers; Biometry; Biostatistics Core; Brain; Brain Injuries; Caring; Characteristics; Chronic; Chronic Care; Clinical; Clinical Research; Collaborations; Core Facility; Data; Data Security; Dementia; Diagnostic; Elements; Enrollment; Epidemiology; Family member; Functional disorder; Funding; Funding Mechanisms; General Population; Guidelines; Head; Healthcare; Infrastructure; Knowledge; Late Effects; Leadership; Link; Long-Term Effects; Mental Health; Military Personnel; Mission; NIH Program Announcements; Nature; Nerve Degeneration; Nervous System Trauma; Neurocognitive Deficit; Neurodegenerative Disorders; Neurologic; Neurologic Signs; Neurosciences; Outcome; Pain; Phenotype; Population; Population Characteristics; Post-Traumatic Stress Disorders; Prevalence; Private Sector; Quality Control; Research; Research Personnel; Risk Factors; Sensory Disorders; Sleep; Support System; Symptoms; Therapeutic; Time; Veterans; Woman; Work; care systems; chronic pain; cohort; combat; comorbidity; data management; experience; follow-up; health economics; improved; knowledge translation; mild traumatic brain injury; neuroimaging; neurosensory; patient oriented; protective factors; research study; service member; tool

The Chronic Effects of Neurotrauma Consortium (CENC; W81XWH-13-2-0095) has been a highly productive, coordinated, multicenter, basic science-to-bedside, research collaboration led by VCU/VA researcher David Cifu, MD and jointly funded since 2013 by the DoD and VA. CENC linked basic, translational, epidemiologic, and clinical neuroscience researchers from the VA, military, academia, and private sector to effectively address the diagnostic challenges and therapeutic ramifications of mild traumatic brain injury (mTBI) and its potential long-term effects. Experienced and proven researchers from the CENC comprise the LIMBIC team at the level of Consortium Leadership, Core Facility, and Research Study Directors. This proven team of leaders, infrastructure supporters and researchers will initiate targeted, expanded research studies that extend CENC research findings, address all priorities (required and secondary research elements) detailed in the program announcement, and will produce deliverables for the clinicians in the field. The four infrastructure Cores (Biomarkers, Neuroimaging, Data and Biostatistics, Clinical Studies) will work in concert to accomplish three overarching, interrelated aims: Aim 1. Transition and expand CENC to LIMBIC -- Enroll and expand sizes of relevant cohorts of Veterans and Servicemembers; expand data points collected; collect data in accordance with established guidelines; and identify and describe key characteristics of populations to guide rigorous studies on the nature and degree of mTBI late effects in combat Vs/SMs over time. Aim 2. Comorbidities & Neurologic sequela -- Determine prevalence and associations of mTBI with important comorbidities and neurologic sequela, such as dementia and neurodegenerative disease, pain, psychological health including PTSD, and neurosensory deficits. Determine nature and degree of mTBI late effects over time. Aim 3. Phenotypes -- Identify characteristics (e.g., repetitive mTBI, deployment-only mTBI, frequent low level blast or other subconconcussive head/brain impact exposure, baseline neurocognitive deficits, presence of neurologic signs, presence of symptoms), pathophysiology, biomarkers, and subpopulations (e.g., women) that serve as risk or protective factors for long-term outcomes such as neurodegeneration, symptom burden and health economics. LIMBIC will continue the mission begun by CENC, which has the Veterans, Service Members, and their family members at the center of the work performed, to develop, deploy, and disseminate patient-centered health care tools and strategies. Work conducted to-date has expanded knowledge in the areas of chronic pain, sleep, sensory disorders, psychological health, and return to work. Knowledge translation underway includes improving both care and systems of care to the population, translatable to both military and the general public populations. We are poised to achieve LIMBIC’s intent to “improve acute TBI care and subsequent support systems for chronic care following mTBI”.

神经创伤协会（CENC; W81 XWH-13-2-0095）的慢性效应是一个高产， 由VCU/VA研究员大卫领导的协调、多中心、基础科学到床边的研究合作 Cifu，MD，自2013年以来由国防部和VA共同资助。CENC将基础、转化、流行病学、 以及来自退伍军人事务部、军方、学术界和私营部门的临床神经科学研究人员， 轻度创伤性脑损伤（mTBI）的诊断挑战和治疗后果及其潜力 长期影响。来自CENC的经验丰富和久经考验的研究人员组成了LIMBIC团队， 联盟领导，核心设施，和研究研究主任。这支久经考验的领导团队， 基础设施支持者和研究人员将启动有针对性的、扩大的研究， 研究结果，解决方案中详细说明的所有优先事项（必需和次要研究要素） 公告，并将为该领域的临床医生提供可交付成果。 四个基础设施核心（生物标志物、神经成像、数据和生物统计学、临床研究）将在 共同努力实现三个相互关联的总体目标： 目标1。过渡和扩大CENC到LIMBIC -招募和扩大相关退伍军人群体的规模， 服务成员;扩大收集的数据点;根据既定准则收集数据;以及 确定和描述人口的主要特征，以指导对人口的性质和程度的严格研究。 随着时间的推移，mTBI在战斗VS/SM中的后期影响。 目标2.共病和神经系统后遗症-确定mTBI的患病率和与重要 合并症和神经系统后遗症，如痴呆和神经退行性疾病，疼痛，心理 包括创伤后应激障碍和神经感觉缺陷。确定随时间推移mTBI晚期效应的性质和程度。 目标3。表型-确定特征（例如，重复性mTBI、仅部署mTBI、频繁低水平 冲击波或其他亚震荡性头部/脑部撞击暴露，基线神经认知缺陷， 神经学体征，症状的存在），病理生理学，生物标志物，和亚群（例如，妇女）， 作为长期结果（例如神经退行性疾病、症状负担和 卫生经济学。 LIMBIC将继续CENC开始的使命，CENC有退伍军人，服务人员和他们的家人 成员在中心的工作执行，发展，部署，并传播以病人为中心的健康 护理工具和策略。迄今为止进行的工作扩大了慢性疼痛领域的知识， 睡眠、感觉障碍、心理健康和重返工作岗位。正在进行的知识翻译包括 改善对民众的护理和护理系统，使其既适用于军队，也适用于普通民众; 人口。我们准备实现LIMBIC的意图，“改善急性TBI护理和后续支持 mTBI后的慢性护理系统”。