Distribution of Molecular Features for Colorectal Cancers in Northern Tanzania

坦桑尼亚北部结直肠癌的分子特征分布

• 批准号: 10845027
• 负责人: Robert J. Coffey
• 金额: $ 12.5万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-09 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10845027
• 关键词: Academic Medical Centers; Administrative Supplement; Cancer Center; Caring; Characteristics; Clinical; Colon Carcinoma; Colorectal; Colorectal Cancer; Epidemiologist; Funding; Knowledge; Laboratories; Malignant neoplasm of gastrointestinal tract; Medical center; Mentors; Molecular; Oncology; Pathology; Patients; Pattern; Records; Rectal Cancer; Registries; Research; Research Assistant; Research Personnel; Research Project Grants; Role; Sampling; Surgeon; Tanzania; Testing; Training; Travel; Wages; career; career development; colon cancer patients; early onset; interest; laptop; low and middle-income countries; prospective; response; social; tumor

PROJECT SUMMARY/ABSTRACT: Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer (P50CA236733) This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT- CA-23-038. The Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer focuses on colorectal cancer. This project for the Administrative Supplement for NCI Global Oncology Mentored Research will assess the pattern of molecular characteristics for colorectal cancer and assess feasibility for molecular testing for CRC through a formal mentored research relationship between researchers at Vanderbilt University Medical Center and a mentee (a colorectal surgeon) at Kilimanjaro Christian Medical Center (KCMC), Tanzania. Dr. Ayesiga Herman is an early-career low-middle income country researchers (ESLIs) who is actively involved in the care of colorectal cancer patients in Northern Tanzania. He has observed an increasing proportion of patients with early onset CRC in Tanzania, and the molecular features of these tumors are not known. We think the knowledge to these features in will play a role on management and surveillance for CRC. We therefore propose a study to look at the distribution of molecular features for CRC patients and assess their association with social demographic and clinical factors. Also we will assess the feasibility for a prospective registry for these molecular features at KCMC. We will retrospectively review records and analyze the molecular features for colon and rectal cancer samples banked in KCMC pathology laboratory for the past 5 years. Also a prospective registry will be established for the new CRC patients and assess the feasibility for molecular testing at KCMC. Funds from this subcontract will be used for molecular features analysis, support the salaries for ESLIs, a research assistant, and a laptop for the research assistant. Dr. Alexander Hawkins (colorectal surgeon), Martha J. Shrubsole, (colorectal cancer epidemiologist) and Robert J. Coffey, MD, (Researcher) comprise the research mentoring team at Vanderbilt. Prof Blandina Mmbaga will be the local mentor for Dr. Herman and she will meet monthly to assess the progress of the project. As primary mentor, Dr. Hawkins will be responsible for career development and research project mentoring for Dr. Herman. In that role, he will meet weekly via zoom to discuss the progress of the project, will travel once to KCMC, Tanzania for training during the year, and will the ESLIs for training at Vanderbilt once during the year.

项目总结/摘要：范德比尔特-英格拉姆癌症中心胃肠道孢子 癌症（P50 CA 236733） 本申请是为了回应特别利益通知（NOSI）而提交的，该通知被确定为不- CA-23-038 Vanderbilt-Ingram癌症中心胃肠道癌症SPORE专注于结直肠癌。这 NCI全球肿瘤学指导研究行政补充项目将评估 结直肠癌的分子特征模式，并评估CRC分子检测的可行性 通过范德比尔特大学医学院的研究人员之间的正式指导研究关系， 坦桑尼亚基利曼哈罗基督教医疗中心（KCMC）的中心和学员（结直肠外科医生）。博士 Ayesiga赫尔曼是一个职业生涯早期的中低收入国家研究人员（ESLI）， 在坦桑尼亚北方的结肠直肠癌患者的护理中。他注意到， 在坦桑尼亚的早发型CRC患者中，这些肿瘤的分子特征尚不清楚。我们 认为对这些特征的认识将对CRC的管理和监测起到一定的作用。我们 因此，建议开展一项研究，观察CRC患者的分子特征分布，并评估其 与社会人口统计学和临床因素相关。此外，我们将评估潜在的可行性， 在KCMC注册这些分子特征。我们将回顾性地审查记录， KCMC病理实验室过去5年储存的结肠癌和直肠癌样本的分子特征 年还将为新的CRC患者建立前瞻性登记，并评估 KCMC的分子测试该基金将用于分子特征分析， ESLI的工资，一个研究助理，和一台笔记本电脑的研究助理。亚历山大霍金斯医生 （结直肠外科医生），Martha J. Shrubsole（结直肠癌流行病学家）和Robert J. Coffey，MD， （研究员）组成了范德比尔特的研究指导小组。Blandina Mmbaga教授将担任当地 她是赫尔曼博士的导师，她将每月开会评估项目的进展情况。作为主要导师， 博士霍金斯将负责赫尔曼博士的职业发展和研究项目指导。在 他将每周通过zoom开会讨论项目的进展情况，将前往KCMC一次， 坦桑尼亚的培训，并将在范德比尔特培训一次。

项目成果

Determination of distinctive hypomethylated genes in African American colorectal neoplastic lesions.

非洲裔美国人结直肠肿瘤病变中独特低甲基化基因的测定。

• DOI: 10.1177/1756284820905482
• 发表时间: 2020
• 期刊: Therapeutic advances in gastroenterology
• 影响因子: 4.2
• 作者: Ashktorab,Hassan;Washington,Kareem;Zarnogi,Shatha;Shakoori,Afnan;Varma,Sudhir;Lee,Edward;Shokrani,Babak;Laiyemo,Adeyinka;Brim,Hassan
• 通讯作者: Brim,Hassan