Distribution of Molecular Features for Colorectal Cancers in Northern Tanzania

项目摘要/摘要：范德比尔特-英格拉姆癌症中心胃肠道孢子 癌症(P50CA236733) 本申请是为回应特别利益通知(NOSI)而提出的，该通知被确认为非- CA-23-038。 范德比尔特-英格拉姆癌症中心的胃肠道癌症孢子研究重点是结直肠癌。这 NCI全球肿瘤学指导性研究行政补充项目将评估 结直肠癌分子特征模式及分子检测的可行性评价 通过范德比尔特大学医学院研究人员之间的正式指导研究关系 他是坦桑尼亚乞力马扎罗基督教医疗中心(KCMC)的一名学员(一名结直肠外科医生)。Dr。 Ayesiga Herman是一名职业生涯早期的中低收入国家研究人员，他积极参与 在坦桑尼亚北部护理结直肠癌患者。他观察到越来越多的人 坦桑尼亚的早发性结直肠癌患者，这些肿瘤的分子特征尚不清楚。我们 认为对这些特征的认识将对铁路局的管理和监督起到一定的作用。我们 因此，建议进行一项研究，以观察结直肠癌患者的分子特征的分布，并评估他们的 与社会人口学和临床因素的关系。此外，我们还将评估未来的可行性 这些分子特征在KCMC注册。我们将回顾记录并分析 过去5年KCMC病理实验室保存的结肠癌和直肠癌样本的分子特征 好几年了。此外，还将为新的结直肠癌患者建立预期的登记，并评估 KCMC的分子测试。本分包合同的资金将用于分子特征分析、支持 ESLI、研究助理和研究助理笔记本电脑的工资。亚历山大·霍金斯博士 (结直肠外科医生)，Martha J.ShRubsolel(结直肠癌流行病学家)和Robert J.Coffey，医学博士， (研究员)组成范德比尔特的研究指导团队。布兰迪娜·姆姆巴加教授将是当地的 赫尔曼博士的导师和她将每月会面，评估项目的进展情况。作为主要导师， 霍金斯博士将负责赫尔曼博士的职业发展和研究项目指导。在……里面 这一角色，他将每周通过Zoom会面，讨论项目进展，将前往KCMC一次， 在这一年期间，将向坦桑尼亚提供一次培训，并将在这一年为范德比尔特培训一次ESLIS。

PROJECT SUMMARY/ABSTRACT: Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer (P50CA236733) This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT- CA-23-038. The Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer focuses on colorectal cancer. This project for the Administrative Supplement for NCI Global Oncology Mentored Research will assess the pattern of molecular characteristics for colorectal cancer and assess feasibility for molecular testing for CRC through a formal mentored research relationship between researchers at Vanderbilt University Medical Center and a mentee (a colorectal surgeon) at Kilimanjaro Christian Medical Center (KCMC), Tanzania. Dr. Ayesiga Herman is an early-career low-middle income country researchers (ESLIs) who is actively involved in the care of colorectal cancer patients in Northern Tanzania. He has observed an increasing proportion of patients with early onset CRC in Tanzania, and the molecular features of these tumors are not known. We think the knowledge to these features in will play a role on management and surveillance for CRC. We therefore propose a study to look at the distribution of molecular features for CRC patients and assess their association with social demographic and clinical factors. Also we will assess the feasibility for a prospective registry for these molecular features at KCMC. We will retrospectively review records and analyze the molecular features for colon and rectal cancer samples banked in KCMC pathology laboratory for the past 5 years. Also a prospective registry will be established for the new CRC patients and assess the feasibility for molecular testing at KCMC. Funds from this subcontract will be used for molecular features analysis, support the salaries for ESLIs, a research assistant, and a laptop for the research assistant. Dr. Alexander Hawkins (colorectal surgeon), Martha J. Shrubsole, (colorectal cancer epidemiologist) and Robert J. Coffey, MD, (Researcher) comprise the research mentoring team at Vanderbilt. Prof Blandina Mmbaga will be the local mentor for Dr. Herman and she will meet monthly to assess the progress of the project. As primary mentor, Dr. Hawkins will be responsible for career development and research project mentoring for Dr. Herman. In that role, he will meet weekly via zoom to discuss the progress of the project, will travel once to KCMC, Tanzania for training during the year, and will the ESLIs for training at Vanderbilt once during the year.