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Improved Characterization of Postural Blood Pressure Change in Older Adults

改善老年人体位血压变化的特征

基本信息

批准号：
10218256
负责人：
STEPHEN P JURASCHEK
金额：
$ 19.14万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10218256
关键词：
Adult Antihypertensive Agents Aptitude Auscultation Award Biometry Blood Pressure Cardiovascular Diseases Cessation of life Clinical Clinical Investigator Clinical Research Clinical Trials Complex Consensus Cross-Sectional Studies Data Data Analyses Data Collection Devices Diagnosis Diastolic blood pressure Discipline of Nursing Doctor of Philosophy Dose Drops Elderly Emergency department visit Ensure Epidemiology Faculty Fall prevention Foundations Funding Future Hypertension Hypotension Infrastructure Internal Medicine Intervention Intervention Trial Lightheadedness Low Prevalence Measurement Measures Medical Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methods Older Population Orthostatic Hypotension Outcome Participant Phase Physical Function Physical assessment Polypharmacy Populations at Risk Positioning Attribute Posture Prevention Prospective cohort study Protocols documentation Public Health Publishing Randomized Recording of previous events Refractory Research Risk Scientist Specificity Standardization Stroke Supination Symptoms Syncope Techniques Time Training United States National Institutes of Health Universities Visit Vitamin D Vitamin D supplementation advanced analytics base blood pressure regulation blood treatment career career development clinically relevant collaborative environment complex data design diaries experience faculty mentor fall injury fall risk falls follow-up high risk hormone regulation hypertension treatment improved medical schools mouse model multidisciplinary new technology novel patient oriented patient oriented research prevent prognostic quality assurance randomized trial recruit response secondary analysis side effect skills therapy design time interval trial design validation studies

项目摘要

Project Summary/Abstract Stephen Juraschek, MD, PhD, is a research fellow in the Division of General Internal Medicine at Johns Hopkins University, School of Medicine. He is applying for a Mentored Patient-Oriented Research Career Development (K23) Award, titled “Improved characterization of postural blood pressure change in older adults.” His rigorous training and impressive body of research have prepared him for this next phase of his career. Through this award, Stephen will successfully transition from a scientist proficient in conducting secondary data analyses to an independent clinical investigator, skilled in generating primary data in trials of interventions designed to prevent and treat blood pressure-related cardiovascular disease in older adults. Stephen completed his MD-PhD training in just six years with a strong foundation in epidemiology and biostatistics. He has demonstrated great aptitude in publishing secondary analyses of completed studies focused on cardiovascular disease and hypertension. This K23 proposal, represents an opportunity for Stephen to acquire the skills that are necessary to become an independent clinical investigator. These skills include (1) a rigorous, hands-on experience in primary data collection and (2) advanced analytic techniques related to the design and conduct of clinical studies, including trials with adaptive designs. Stephen's proposal focuses on orthostatic hypotension, an incredibly important yet poorly defined side effect of antihypertensive therapy in older adults. His proposal includes a 5-year plan that leverages the infrastructure of a funded NIH trial to: (1) characterize orthostatic hypotension using a continuous feed device in 1100 participants of STURDY (cross-sectional validation study); (2) determine the association of novel metrics of orthostatic hypotension with subsequent falls (prospective cohort study); and (3) evaluate whether vitamin D lowers the prevalence of orthostatic hypotension and reduces its symptoms (response-adaptive clinical trial). Successful completion of this proposal will answer ongoing controversies surrounding the assessment and characterization of orthostatic hypotension in relation to relevant clinical outcomes as well as evaluate a novel treatment of orthostatic hypotension. Stephen's research will occur in the rich, diverse, and collaborative environment at Johns Hopkins University under the guidance and support of a dedicated group of faculty mentors, led by Dr. Lawrence Appel, MD, MPH, and Dr. Edgar Miller, MD, PhD. His mentorship team is truly multidisciplinary with faculty from the Johns Hopkins Schools of Medicine, Nursing, and Public Health. Together, this team will ensure that Stephen emerges with expertise in patient-centered, primary data collection, complex data analysis, and skills in the design and analysis of trials, including those with adaptive designs. As a result of this mentored training, Stephen will be fully equipped for a highly productive career as an independent clinical investigator focused on the prevention and treatment of blood pressure-related cardiovascular disease in older adults.

项目总结/文摘