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The American Lung Association (ALA) Lung Health Cohort

美国肺脏协会 (ALA) 肺部健康队列

基本信息

批准号：
10219828
负责人：
Mercedes Renee Carnethon
金额：
$ 419.2万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10219828
关键词：
Adult Age Air Pollution American Lung Association Attention Bioinformatics Biological Biological Markers Biological Specimen Banks Blood Cardiovascular system Cells Chest Chronic Chronic Disease Chronic Obstructive Airway Disease Chronic lung disease Clinical Clinical Research Communities Data Data Coordinating Center Development Electronic cigarette Environmental Epidemiology Evaluation Evolution Exposure to Fibrinogen Functional Imaging Funding Future Gene Expression Geography Goals Health Health Promotion Health behavior Image Impairment Individual Infrastructure Inhalation Exposure Injury Intention Intercept Investigation Knowledge Life Cycle Stages Longevity Longitudinal Studies Lung Lung diseases Marijuana Matrilysin Measurement Measures Nasal Epithelium Nose Occupational Outcome Participant Patient Outcomes Assessments Patient Self-Report Pattern Phenotype Physical Fitness Physical activity Physicians Predisposition Prevention approach Prevention strategy Primary Prevention Proteins Publishing Pulmonary Surfactant-Associated Protein D Recording of previous events Research Personnel Respiratory Signs and Symptoms Risk Risk Factors Scanning Social Behavior Structure of respiratory epithelium Testing Translating Work X-Ray Computed Tomography age related aged base blood-based biomarker chest computed tomography clinical care cohort emerging adult injured airway insight lung injury metropolitan modifiable risk multidisciplinary novel prevent pulmonary function receptor for advanced glycation endproducts recruit resilience respiratory respiratory health response soluble RAGE transcriptome transcriptomics young adult

项目摘要

Project Summary/Abstract Pulmonary physicians and respiratory researchers define respiratory health as the absence of lung disease. This simplistic definition has limited the development of a robust approach to the prevention of lung disease. Because of the absence of adult life-course studies focused primarily on lung health, the intermediate phenotypes of impaired lung health (which exist on a continuum between ideal lung health and lung disease) have not been well-defined. There is a critical need to identify modifiable risk factors and biomarkers for impaired lung health that will allow clinicians to recognize impaired lung health and intervene before chronic lung disease develops. We will leverage the national infrastructure of the American Lung Association’s (ALA) Airways Clinical Research Centers (ACRC) to form the first national cohort of adults focused on respiratory health. We will recruit 4000 community-dwelling adults aged 25-35 from 17 metropolitan regions across the U.S. for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages. Our long-term goal is to determine early adulthood factors that influence risk for future lung disease through detailed assessments of exposures (environmental, socio-behavioral, and occupational) and responses (physiologic, imaging-based, and biological including the nasal epithelial transcriptome). In this initial baseline evaluation, informed by our preliminary data indicating impaired lung health (lower lung function, self-report of respiratory symptoms, lung injury on chest CT scan) precedes the development of chronic lung disease, we will test several hypotheses regarding the risk factors and manifestations of impaired lung health in young adults through the following specific aims: (1) Determine whether modifiable exposures and risk factors (lifetime air pollution, potentially noxious inhalational exposures such as marijuana and e-cigarettes, reduced physical activity) are associated with lower lung function and greater burden of respiratory symptoms in young adults; (2) Determine whether CT-measurements of small airway and parenchymal lung injury are associated with lower lung function and greater burden of respiratory symptoms in young adults; (3) Determine the association between the nasal respiratory epithelial transcriptome and selected blood biomarkers, CT- measured small airway abnormality and parenchymal lung injury in young adults. We will test the hypotheses that (1) lifetime exposure to air pollution and other inhalational exposures (e.g. e-cigarettes and marijuana) are associated with impaired lung health; (2) novel imaging measurements are associated with impaired lung health; and (3) respiratory compartment-specific (nasal epithelial transciptome) and blood based biomarkers provide insight into the biologic underpinnings of impaired lung health. These studies will describe the divergence between respiratory health and disease and provide a platform for health promotion and the primary prevention of lung disease.

项目总结/文摘