Integrated Cartilage Repair
综合软骨修复
基本信息
- 批准号:10221602
- 负责人:
- 金额:$ 35.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-13 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAllogenicAmericanAnabolismAnimal ModelAutologousBiochemicalBiologicalBiological AssayBone TransplantationCartilageCellsCeramicsChemistryChemotactic FactorsChondrocytesClinicalClinical TreatmentCountryDefectDegenerative polyarthritisDepositionDevelopmentDevicesDoseExhibitsFiberFibrocartilagesGenerationsGoalsGrowthHomingHydrogelsHydroxyapatitesImmunohistochemistryIn VitroInsulin-Like Growth Factor IInterventionKineticsLeadLeftLesionMediatingMethodsMineralsModelingMusculoskeletalNanotechnologyOperative Surgical ProceduresOryctolagus cuniculusOutcomePainPatientsPhenotypePolymersProductionQuality of lifeReplacement ArthroplastyReportingResearchSecureSoft Tissue InjuriesSpatial DistributionStem Cell FactorStructureSystemSystems IntegrationTestingTimeTissue AdhesivesTissue EngineeringTissuesUnited StatesWorkarthropathiesarticular cartilagebasebonecalcium phosphatecartilage degradationcartilage repaircartilage transplantationcell motilityclinically relevantclinically significantdensitydesigndisabilityexperiencefunctional outcomeshealingimprovedin vivoinnovationjoint destructionjoint functionmechanical propertiesmigrationmineralizationnanofibernanoparticlenovelosteochondral tissuepoly(lactide)preventrepairedresponserestorationsample fixationsoft tissuesubchondral bonetreatment strategytricalcium phosphate
项目摘要
PROJECT SUMMARY
Osteoarthritis, or degeneration of cartilage, is one of the most prevalent joint diseases and remains the most
common cause of work-related disabilities in this country. Current osteoarthritis treatment options often fail due
to lack of integration between the cartilage graft and the host tissues, including both the surrounding cartilage
and underlying bone. Therefore, there exists an unmet clinical need for integrative solutions for cartilage repair.
The objective of the proposal is to determine the efficacy of an integrative nanofiber cup system in promoting
graft-cartilage and graft-bone integration. It is hypothesized that native cartilage integration will be facilitated by
controlling chondrocyte migration to the graft-cartilage junction, and osteointegration will be enhanced by
optimizing calcium phosphate (CaP) nanoparticle bioactivity, concentration and spatial distribution. To test this
hypothesis, the nanofiber cup system will be evaluated both in vitro (Aims 1 and 2) and in vivo (Aim 3) with a
hydrogel-based cartilage graft that exhibits mechanical properties within the range of articular cartilage. An
osteochondral explant model will be used to test both graft-cartilage and graft-bone integration in vitro, while a
clinically relevant rabbit osteoarthritis model will be used to test host tissue integration in vivo. In addition to
evaluating cell and tissue phenotypes via immunohistochemistry and biochemical assays, other functional
outcomes such as integration strength and quantitative compositional mapping across tissue boundaries will
also be used to determine efficacy in vitro and in vivo.
In addition to targeting a clinically significant problem, the proposed approach represents a new paradigm in
cartilage repair. The nanofiber integration system is novel because of its: 1) unique nanofiber-based cup design,
2) ability to promote simultaneous graft-cartilage and graft-bone integration, and 3) compatibility with a variety of
cartilage grafts. This innovative approach for integrated cartilage repair will enable the restoration of cartilage
integrity and long-term function. Moreover, it will help to prevent further joint degeneration and thereby reduce
the need for aggressive and often suboptimal interventions (e.g. total joint replacements and related revision
surgeries). Successful completion of the planned studies will lead to the development of a new generation of
nanotechnology-based fixation devices for the treatment of soft tissue injuries.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('HELEN H LU', 18)}}的其他基金
Dental-Biomedical Engineering Scholars Training (D-BEST) Program
牙科生物医学工程学者培训(D-BEST)计划
- 批准号:
10714037 - 财政年份:2023
- 资助金额:
$ 35.93万 - 项目类别:
Interface Tissue Engineering for Soft Tissue-to-Bone Integration
软组织与骨整合的界面组织工程
- 批准号:
8067092 - 财政年份:2008
- 资助金额:
$ 35.93万 - 项目类别:
Interface Tissue Engineering for Soft Tissue-to-Bone Integration
软组织与骨整合的界面组织工程
- 批准号:
8271269 - 财政年份:2008
- 资助金额:
$ 35.93万 - 项目类别:
Interface Tissue Engineering for Soft Tissue-to-Bone Integration
软组织与骨整合的界面组织工程
- 批准号:
8477129 - 财政年份:2008
- 资助金额:
$ 35.93万 - 项目类别:
Biphasic Nanofiber-based Scaffold for Tendon-to-Bone Integration
用于肌腱与骨整合的双相纳米纤维支架
- 批准号:
7514940 - 财政年份:2008
- 资助金额:
$ 35.93万 - 项目类别:
Biphasic Nanofiber-based Scaffold for Tendon-to-Bone Integration
用于肌腱与骨整合的双相纳米纤维支架
- 批准号:
7645643 - 财政年份:2008
- 资助金额:
$ 35.93万 - 项目类别:
Interface Tissue Engineering for Soft Tissue-to-Bone Integration
软组织与骨整合的界面组织工程
- 批准号:
7533812 - 财政年份:2008
- 资助金额:
$ 35.93万 - 项目类别:
Interface Tissue Engineering for Soft Tissue-to-Bone Integration
软组织与骨整合的界面组织工程
- 批准号:
7645644 - 财政年份:2008
- 资助金额:
$ 35.93万 - 项目类别:
Interface Tissue Engineering for Soft Tissue-to-Bone Integration
软组织与骨整合的界面组织工程
- 批准号:
8660647 - 财政年份:2008
- 资助金额:
$ 35.93万 - 项目类别:
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