Developmental Neuroimaging Core

发展性神经影像核心项目摘要 发展神经成像核心(DNC)一直是，并将继续是快速 在典型和非典型发育过程中，我们对大脑结构和功能的理解不断增强。这个 DNC活动的广度包括通过最先进的临床前成像结合动物成像 通过过多的高端人体成像系统进行便利和人体成像。民主党全国委员会将提供州- 最先进的神经成像服务，以最大限度地提高中心研究人员的IDD研究的质量和影响， 优化影像作为创新工具在预测和干预中的应用 发展性残疾，并提供一系列咨询和分析服务，帮助新的和早期的 阶段调查人员将成像研究纳入他们的研究工作。民主党全国委员会将发展创新 神经成像方法，并使大型和不断增长的IDDRC@WUSTL调查员能够接触到它们 社区。DNC将加速神经成像的进步，其具体目标如下：(1) 向IDDRC社区提供服务，促进使用磁共振成像和光学 临床前和临床研究中的影像技术。Subaim 1a：提供优质、全面的 研究设计咨询，包括样本选择、主题准备、技术建议、权力 考虑与样本量、大脑-行为基因数据关联以及大脑-环境数据关联相关的因素。 Subaim 1b：为刚果民主共和国调查人员进行具有成本效益的数据获取，包括开发主题 准备方案，指定采集参数，优化成像质量，并提供所有必要的 进行扫描的技术支持。Subaim 1c：提供数据处理、信息学和分析服务 协助影像数据与基因组、表型和环境数据的整合。(2)追求技术 推动IDD研究的进展。Subaim 2a：开发和比较静息状态功能连通性 啮齿类动物的MRI方法和光学方法。Subaim 2b：优化临床MRI数据采集以满足或 超越研究质量，扩大其用于研究表型的用途。

Developmental Neuroimaging Core Project Summary The Developmental Neuroimaging Core (DNC) has been, and will continue to be, integral to the rapid growth in our understanding of the brain’s structure and function during typical and atypical development. The breadth of DNC activity includes the incorporation of animal imaging through a state-of-the-art preclinical imaging facility and human imaging through a plethora of high-end human imaging systems. The DNC will provide state- of-the art neuroimaging services to maximize the quality and impact of IDD research by Center investigators, to optimize the application of imaging as a translational tool for innovation in prediction and intervention of developmental disabilities, and to provide a range of consultative and analytic services to help new and early stage investigators incorporate imaging research into their research efforts. The DNC will develop innovative neuroimaging methodologies and make them accessible to the large and growing IDDRC@WUSTL investigator community. The Specific Aims of the DNC, which will accelerate advances in neuroimaging, are as follows: (1) To provide services to the IDDRC community that facilitate the use of magnetic resonance imaging and optical imaging techniques in both preclinical and clinical studies. Subaim 1a: Provide high-quality, comprehensive consultation for study design, including sample selection, subject preparation, technological advice, power considerations related to sample size, brain-behavior gene data linkage, and brain-environmental data linkage. Subaim 1b: Conduct cost-efficient data acquisition for IDDRC investigators, including developing subject preparation protocols, specifying acquisition parameters, optimizing imaging quality, and providing all necessary technical support for conducting the scan. Subaim 1c: Provide data processing, informatics, and analytic services to assist the integration of imaging data with genomic, phenotypic and environmental data. (2) Pursue technical developments to advance IDD research. Subaim 2a: Develop and compare resting state functional connectivity MRI methods with optical methods for rodents. Subaim 2b: Optimize clinical MRI data acquisition to meet or exceed research quality to expand its use for research phenotyping.