Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心

• 批准号: 10224123
• 负责人: Hui Zhang
• 金额: $ 16.51万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-17 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224123
• 关键词: Adherence; Bioinformatics; Biological; Biometry; Brain; Brain Neoplasms; Cells; Characteristics; Clinical; Clinical Data; Clinical Research; Clinical Trials; Code; Collaborations; Complement; Comprehensive Cancer Center; Consultations; Custom; Data; Data Analyses; Data Collection; Data Science; Data Set; Data Storage and Retrieval; Databases; Development; Ensure; Environment; Evaluation; Experimental Designs; Fostering; Guidelines; Individual; Investigation; Maintenance; Malignant neoplasm of brain; Modification; Molecular; Monitor; Monitoring Clinical Trials; Output; Patient Care; Patients; Protocols documentation; Registries; Reporting; Reproducibility; Research; Research Design; Research Support; Safety; Secure; Statistical Data Interpretation; base; bioinformatics pipeline; clinical database; clinical trial participant; complex data; data management; data registry; data resource; data standards; design; electronic data; experimental study; genetic manipulation; high dimensionality; improved; medical schools; member; novel; patient safety; pre-clinical; preclinical study; programs; translational approach; tumor

BIOSTATISTICS AND BIOINFORMATICS CORE: SUMMARY The Biostatistics and Bioinformatics Core (B&B Core) is a central component of the Brain Tumor SPORE, providing state-of-the-art integrated data science support to all Brain Tumor SPORE projects. Database development and maintenance will provide a centralized resource for data tracking for preclinical studies, ensuring efficient reporting and statistical analysis of all experiments. In addition, clinical databases will be developed in conjunction with all project teams to complement existing clinical trial data registries at Northwestern and ensure custom data capture in a highly secure environment. Bioinformatics activities of the B&B Core are central to discovery and will help define new and significant research directions. The large omics data sets that will be generated in the Brain Tumor SPORE Projects require specialized expertise for preprocessing, analysis and interpretation of molecular and biological consequences of genetic manipulations and treatments. Bioinformatics functionality provided by the B&B Core will provide this crucial assistance for all proposed Brain Tumor SPORE Projects. Biostatistical activities of the B&B Core are central to the concerns of rigor and reproducibility: by providing study design guidance, data management, statistical analysis and consultation for interpretation of results the core will see that reported results have been rigorously controlled and will be reproducible by others. All functions of the B&B Core will be conducted in association with the following Specific Aims: AIM 1: Establish and maintain database functionality for all preclinical and clinical data; AIM 2: Provide bioinformatics collaboration and support for pre-processing and analysis of high- dimensional omics data, including array-based and sequencing data; AIM 3: Provide biostatistical collaboration and support for design of preclinical studies and clinical trials, as well as statistical analyses of all accumulated data. Through these activities the B&B Core will serve as a key contributor to all individual projects and will ensure that project output is accurate, reliable, and of the highest quality.

生物统计学和生物信息学核心：总结 生物统计学和生物信息学核心（B&B 核心）是脑肿瘤 SPORE 的核心组成部分， 为所有脑肿瘤 SPORE 项目提供最先进的综合数据科学支持。数据库 开发和维护将为临床前研究的数据跟踪提供集中资源， 确保所有实验的有效报告和统计分析。此外，临床数据库将 与所有项目团队共同开发，以补充现有的临床试验数据注册 西北大学并确保在高度安全的环境中捕获自定义数据。生物信息学活动 B&B Core 是发现的核心，将有助于定义新的重要研究方向。大的 将在脑肿瘤 SPORE 项目中生成的组学数据集需要专门的专业知识 基因操作的分子和生物学后果的预处理、分析和解释 和治疗。 B&B Core 提供的生物信息学功能将为 所有拟议的脑肿瘤孢子项目。 B&B Core 的生物统计活动是关注的焦点 严谨性和可重复性：通过提供研究设计指导、数据管理、统计分析和 结果解释咨询 核心将看到报告的结果受到严格控制 并且可以被其他人复制。 B&B Core 的所有职能将与 以下具体目标： 目标 1：建立和维护所有临床前和临床的数据库功能 数据;目标 2：为高通量数据的预处理和分析提供生物信息学协作和支持 维度组学数据，包括基于阵列的数据和测序数据；目标 3：提供生物统计协作 并支持临床前研究和临床试验的设计，以及所有累积的统计分析 数据。通过这些活动，B&B Core 将成为所有单个项目的关键贡献者，并将 确保项目输出准确、可靠且具有最高质量。