Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心：摘要 生物统计学和生物信息学核心（B&B核心）是脑肿瘤孢子的核心组成部分， 为所有脑瘤孢子项目提供最先进的综合数据科学支持。数据库 开发和维护将为临床前研究的数据跟踪提供集中资源， 确保所有实验的有效报告和统计分析。此外，临床数据库将 与所有项目团队共同开发，以补充现有的临床试验数据登记， 西北和确保定制数据捕获在一个高度安全的环境。生物信息学活动 B&B Core是发现的核心，将有助于定义新的重要研究方向。大 将在脑肿瘤孢子项目中生成的组学数据集需要专门的专业知识， 预处理、分析和解释遗传操作的分子和生物学后果 和治疗。由B&B Core提供的生物信息学功能将为以下方面提供重要帮助： 所有脑肿瘤孢子项目B&B Core的生物统计活动是关注的核心 严格性和再现性：通过提供研究设计指导、数据管理、统计分析和 咨询结果的解释核心将看到报告的结果得到严格控制 并且将被其他人复制。B&B Core的所有职能将与 目标1：建立和维护所有临床前和临床数据库功能 数据; AIM 2：提供生物信息学合作和支持，用于预处理和分析高 三维组学数据，包括基于阵列的数据和测序数据; AIM 3：提供生物统计协作 并支持临床前研究和临床试验的设计，以及所有累积的 数据通过这些活动，B&B Core将成为所有单个项目的关键贡献者，并将 确保项目输出准确、可靠和最高质量。

BIOSTATISTICS AND BIOINFORMATICS CORE: SUMMARY The Biostatistics and Bioinformatics Core (B&B Core) is a central component of the Brain Tumor SPORE, providing state-of-the-art integrated data science support to all Brain Tumor SPORE projects. Database development and maintenance will provide a centralized resource for data tracking for preclinical studies, ensuring efficient reporting and statistical analysis of all experiments. In addition, clinical databases will be developed in conjunction with all project teams to complement existing clinical trial data registries at Northwestern and ensure custom data capture in a highly secure environment. Bioinformatics activities of the B&B Core are central to discovery and will help define new and significant research directions. The large omics data sets that will be generated in the Brain Tumor SPORE Projects require specialized expertise for preprocessing, analysis and interpretation of molecular and biological consequences of genetic manipulations and treatments. Bioinformatics functionality provided by the B&B Core will provide this crucial assistance for all proposed Brain Tumor SPORE Projects. Biostatistical activities of the B&B Core are central to the concerns of rigor and reproducibility: by providing study design guidance, data management, statistical analysis and consultation for interpretation of results the core will see that reported results have been rigorously controlled and will be reproducible by others. All functions of the B&B Core will be conducted in association with the following Specific Aims: AIM 1: Establish and maintain database functionality for all preclinical and clinical data; AIM 2: Provide bioinformatics collaboration and support for pre-processing and analysis of high- dimensional omics data, including array-based and sequencing data; AIM 3: Provide biostatistical collaboration and support for design of preclinical studies and clinical trials, as well as statistical analyses of all accumulated data. Through these activities the B&B Core will serve as a key contributor to all individual projects and will ensure that project output is accurate, reliable, and of the highest quality.