Core A: Administrative Core

项目总结/摘要 拟议的BioMark项目团队的整体成功取决于一个高效和高度组织化的团队。 有效协调团队工作的行政核心。拟议的《公约》的中心使命是 BioMark项目旨在确定一组可靠的生物标志物，预测治疗后反弹的时间 艾滋病病毒感染者中断治疗。这一核心将设法消除或减少可能损害 团队实现其实验目标。成功的关键是将生动活泼、内容丰富的 团队会议和团队的核心，以促进协同而不是添加剂的方式 科学合作。行政核心围绕三个具体目标组织：具体目标1： 为BioMark团队提供一个健全、有效的管理结构，最大限度地提高科学生产力， 促进成员之间的自由和开放的沟通，允许定期进行战略规划， 确保实施健全的财政做法，以最大限度地利用资源和提高生产力，并促进 适当分享、整理和分析所产生的科学数据。具体目标2：开展 由科学顾问委员会对BioMark团队的进展进行年度科学审查， 成员（从第三年开始）。具体目标3：定期在内部评估所有 科学项目和核心，并根据需要或业绩，以最佳方式重新分配资源， 服务于BioMark团队的总体目标。Warner格林博士将担任该核心的主任。这一核心 将设在格莱斯顿病毒学和免疫学研究所（GIVI），这是一个被广泛认可的机构， 卓越的行政服务。参与BioMark的其他行政人员包括 Julia Roudabush（Gladstone赠款和合同）和Robin Givens（高级执行助理， 主任）。行政核心将安排每两周一次的BioMark执行官视频会议 委员会（格林主席、皮莱、罗恩、西利西亚诺）交替举行全体会议视频会议 BioMark团队审查结果并讨论未来实验。执行委员会将 作为项目的主要决策机构。行政核心还将组织 一个年度战略规划过程，并负责推出BioMark的网站，包括公众和 私人门户网站，后者促进团队成员之间的数据交换。在第三年，科学咨询 委员会将召集一名生物信息学家、艾滋病毒免疫学家和一名艾滋病毒临床试验专家， 作为会员加入，并对整个计划进行年度审查。行政核心还将采取 负责确保四个不同合作ATI试验中心顺利采集标本， 确保这三个项目与生物信息学和生物统计学核心之间的顺利衔接。

Project Summary/Abstract The overall success of the proposed BioMark project team depends on an efficient and highly organized Administrative Core that effectively coordinates the team's efforts. The central mission of the proposed BioMark project is to identify a robust set of biomarkers predicting time to rebound following treatment interruption in HIV infected patients. This core will sek to remove or reduce the obstacles that might impair the team from achieving its experimental goals. Keys to success are the orchestration of lively and informative team meetings and the nucleation of the team in a manner that promotes synergistic rather than additive scientific collaboration. The Administrative Core is organized around three specific aims: Specific Aim 1: To provide a sound, effective administrative structure for the BioMark team that maximizes scientific productivity, promotes free and open communication among members, allows for strategic planning on a regular basis, ensures the implementation of sound fiscal practices to maximize resources and productivity, and promotes the appropriate sharing, collation, and analyses of the scientific data generated. Specific Aim 2: To conduct an annual scientific review of progress of the BioMark team by a Scientific Advisory Board comprised of three members (beginning in year 3). Specific Aim 3: To regularly evaluate internally the performance of all scientific projects and cores and, based on need or performance, to reallocate resources in a manner that best serves the overall goals of the BioMark team. Dr. Warner Greene will serve as Director of this Core. This core will be based at the Gladstone Institute of Virology and Immunology (GIVI), an institution widely recognized for the excellence of its administrative services. Additional administrative staff participating in BioMark will include Julia Roudabush (Gladstone Grants and Contracts) and Robin Givens (Senior Executive Assistant, Office of the Director, GIVI). The Administrative Core will schedule biweekly videoconferences of BioMark's Executive Committee (Greene chair, Pillai, Roan, Siliciano) alternating with videoconferencing meetings of the entire BioMark team for review of results and discussion of future experimentation. The Executive Committee will function as the principal decision-making body within the program. The Administrative Core will also organize an annual strategic planning process and be responsible for launching BioMark's website to include public and private portals, the latter facilitating data exchange among team members. In Year 3, a Scientific Advisory Board will be assembled with plans to invite a bioinformatician, HIV immunologist, and an HIV clinical trialist to join as members and to conduct an annual review of the entire program. The Administrative Core will also take the lead on ensuring smooth specimen acquisition for the four different collaborating ATI trial sites and ensuring a smooth interface between the three projects and the Bioinformatics and Biostatistics Core.