Core A: Administrative Core

项目摘要/摘要 拟议的BioMark项目团队的整体成功取决于一个高效和高度有组织的 有效协调团队工作的管理核心。拟议的中心任务 BioMark项目是确定一组预测治疗后反弹时间的强大生物标记物 中断了艾滋病毒感染患者的治疗。这一核心将努力消除或减少可能损害 团队实现其实验目标。成功的关键是生动活泼和内容丰富的编排 团队会议和团队的核心，以促进协同而不是相加的方式 科学合作。行政核心围绕三个具体目标组织：具体目标1： 为BioMark团队提供健全、有效的管理结构，最大限度地提高科学生产力， 促进成员之间自由和开放的交流，允许定期进行战略规划， 确保实施合理的财政做法，以最大限度地提高资源和生产率，并促进 对产生的科学数据进行适当的共享、整理和分析。具体目标2：开展 由三人组成的科学顾问委员会对BioMark团队进展进行的年度科学审查 会员(从第三年开始)。具体目标3：定期内部评价所有 科学项目和核心，并根据需要或业绩，以最佳方式重新分配资源 服务于BioMark团队的总体目标。华纳·格林博士将担任这一核心的主任。这个核心 将设在格莱斯顿病毒学和免疫学研究所(GIVI)，该机构因 其卓越的行政服务。参与BioMark的其他行政人员将包括 Julia Roudabush(Gladstone赠款和合同)和Robin Givens(高级执行助理，办公室 主任，GIVI)。管理核心将安排BioMark执行人员每两周举行一次视频会议 委员会(格林主席、皮莱、罗安、西里西亚诺)轮流举行视频会议 生物标记团队，用于审查结果和讨论未来的实验。执行委员会将 作为计划内的主要决策机构发挥作用。行政核心还将组织 年度战略规划流程，并负责推出BioMark的网站，以包括公众和 私有门户，后者促进团队成员之间的数据交换。在第三年，一项科学建议 董事会将组成，计划邀请一名生物信息学家、艾滋病毒免疫学家和一名艾滋病毒临床试验人员 作为会员加入，并对整个计划进行年度审查。行政核心也将采取 在确保四个不同的合作ATI试验地点顺利获取标本方面发挥领导作用 确保三个项目与生物信息学和生物统计核心之间的顺利接口。

Project Summary/Abstract The overall success of the proposed BioMark project team depends on an efficient and highly organized Administrative Core that effectively coordinates the team's efforts. The central mission of the proposed BioMark project is to identify a robust set of biomarkers predicting time to rebound following treatment interruption in HIV infected patients. This core will sek to remove or reduce the obstacles that might impair the team from achieving its experimental goals. Keys to success are the orchestration of lively and informative team meetings and the nucleation of the team in a manner that promotes synergistic rather than additive scientific collaboration. The Administrative Core is organized around three specific aims: Specific Aim 1: To provide a sound, effective administrative structure for the BioMark team that maximizes scientific productivity, promotes free and open communication among members, allows for strategic planning on a regular basis, ensures the implementation of sound fiscal practices to maximize resources and productivity, and promotes the appropriate sharing, collation, and analyses of the scientific data generated. Specific Aim 2: To conduct an annual scientific review of progress of the BioMark team by a Scientific Advisory Board comprised of three members (beginning in year 3). Specific Aim 3: To regularly evaluate internally the performance of all scientific projects and cores and, based on need or performance, to reallocate resources in a manner that best serves the overall goals of the BioMark team. Dr. Warner Greene will serve as Director of this Core. This core will be based at the Gladstone Institute of Virology and Immunology (GIVI), an institution widely recognized for the excellence of its administrative services. Additional administrative staff participating in BioMark will include Julia Roudabush (Gladstone Grants and Contracts) and Robin Givens (Senior Executive Assistant, Office of the Director, GIVI). The Administrative Core will schedule biweekly videoconferences of BioMark's Executive Committee (Greene chair, Pillai, Roan, Siliciano) alternating with videoconferencing meetings of the entire BioMark team for review of results and discussion of future experimentation. The Executive Committee will function as the principal decision-making body within the program. The Administrative Core will also organize an annual strategic planning process and be responsible for launching BioMark's website to include public and private portals, the latter facilitating data exchange among team members. In Year 3, a Scientific Advisory Board will be assembled with plans to invite a bioinformatician, HIV immunologist, and an HIV clinical trialist to join as members and to conduct an annual review of the entire program. The Administrative Core will also take the lead on ensuring smooth specimen acquisition for the four different collaborating ATI trial sites and ensuring a smooth interface between the three projects and the Bioinformatics and Biostatistics Core.