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Functional organization of the superior temporal gyrus for speech perception

颞上回言语感知的功能组织

基本信息

批准号：
10224725
负责人：
Edward Chang
金额：
$ 60.85万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10224725
关键词：
Acoustics Address Affect Anatomy Anterior Anterolateral Aphasia Area Auditory Auditory area Behavioral Brain Clinical Code Cognitive Complex Comprehension Custom Decision Making Development Dimensions Dyslexia Electrodes Elements Frequencies Goals Hearing Human Implant Investigation Language Language Disorders Lateral Light Linguistics Masks Medial Methodology Methods Motor Motor Cortex Neurons Neurosciences Neurosurgical Procedures Noise Patients Pattern Perception Play Population Positioning Attribute Property Psychophysics Reporting Research Resolution Role Sensory Signal Transduction Site Speech Speech Perception Speech Sound Stimulus Stream Superior temporal gyrus Supervision Surface Techniques Temporal Lobe Voice Work autism spectrum disorder awake computational neuroscience density information processing innovation language perception lexical neural patterning neuroimaging neurophysiology novel diagnostics population based rehabilitation strategy relating to nervous system response restoration signal processing spatiotemporal speech processing temporal measurement theories

项目摘要

PROJECT SUMMARY The basic mechanisms underlying comprehension of spoken language are unknown. We do not understand, for example, how the human brain extracts the most fundamental linguistic elements (consonants and vowels) from a complex and highly variable acoustic signal. An investigation of the cortical representation of speech sounds can likely shed light on this fundamental question. Previous research has implicated the superior temporal cortex in the processing of speech sounds. However, how the cortex actually represents (i.e. encodes) phonemes is undetermined. The recording of neural activity directly from the cortical surface is a promising approach since it can provide both high spatial and temporal resolution. Here, I propose to examine the mechanisms of phonetic encoding by utilizing neurophysiological recordings obtained during neurosurgical procedures. High-density electrode arrays, advanced signal processing, and direct electrocortical stimulation will be utilized to unravel both local population encoding of speech sounds in the lateral temporal cortex as well as global processing across multiple sensory and cognitive areas.

项目摘要口语理解的基本机制尚不清楚。我们不明白，例如，人脑如何提取最基本的语言元素（辅音和元音）复杂多变的声音信号言语的皮层表征研究声音可能会揭示这个基本问题。先前的研究表明，上级颞叶皮层对语音的处理然而，皮质实际上是如何代表的（即，编码）音素是未确定的。直接从皮层表面记录神经活动是一种这是一种很有前途的方法，因为它可以提供高的空间和时间分辨率。在这里，我建议审查利用神经外科手术中获得的神经生理记录，程序.高密度电极阵列、先进的信号处理和直接皮层电刺激将被用来解开两个当地人口编码的语音在外侧颞叶皮层以及作为跨多个感官和认知区域的全局处理。