Mentored patient-oriented research in disparities in cardiovascular and kidney disease

指导以患者为中心的心血管和肾脏疾病差异研究

• 批准号: 10226233
• 负责人: Orlando M Gutierrez
• 金额: $ 15.96万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-07 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10226233
• 关键词: Adult; African American; Alabama; Albumins; American; Area; Award; Behavioral; Binding Proteins; Bioavailable; Biological; Biological Availability; Biological Markers; Cardiovascular Diseases; Cardiovascular system; Chronic Kidney Failure; Clinical; Clinical Investigator; Clinical Sciences; Clinical Trials; Collaborations; Communities; Consumption; Coupled; Creatinine; Data; Data Set; Development; Diabetes Mellitus; Dietary Intervention; Dietary Phosphorus; Disease; Disease Outcome; Disease Pathway; End stage renal failure; Ensure; Environmental Exposure; Epidemic; Epidemiology; Ethics; European; Excess Mortality; Funding; Gap Junctions; Goals; Head; Health; Hypertension; Individual; Infrastructure; Injury; Injury to Kidney; Intake; Intervention; Investigation; Kidney; Kidney Diseases; Link; Measurement; Medicine; Mentors; Mentorship; Metabolic; Metabolism; Minerals; Nephrology; Neurocognitive; Nutritional Study; Outcome; Outcomes Research; Pathway interactions; Phenotype; Phosphorus; Physician Executives; Physiological; Plant Roots; Play; Race; Reasons for Geographic And Racial Differences in Stroke; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Scientist; Stroke; Time; Training; Translational Research; Tubular formation; United States; United States National Institutes of Health; Universities; Urine; Vitamin D; Vitamin D-Binding Protein; Work; bone; cardiometabolism; career; clinical center; cost; disparity elimination; disparity reduction; epidemiology study; ethnic minority population; experience; feeding; health disparity; interest; investigator training; mid-career faculty; next generation; novel; novel strategies; nutrition; patient oriented; patient oriented research; phosphorus metabolism; programs; racial difference; racial disparity; racial minority; research study; response; skills; urinary

PROJECT SUMMARY Dr. Gutiérrez is an Associate Professor of Medicine and Epidemiology, Section Head of Outcomes and Epidemiology research in the Division of Nephrology, and Medical Director of the Bionutrition Unit in the Center for Clinical and Translational Science (CCTS) at the University of Alabama at Birmingham (UAB). The long- term scientific goal of Dr. Gutiérrez is to build a patient-oriented research (POR) program focused on identifying novel strategies for reducing or eliminating disparities in health outcomes related to cardiovascular disease (CVD) and chronic kidney disease (CKD). In order to accomplish this goal, Dr. Gutiérrez recognizes the critical importance of mentoring the next generation of clinician scientists who can develop the necessary expertise to investigate root causes of disparities in a comprehensive and ethical manner. However, the increasing demands on his time related to sustaining his professional effort for research as well as administrative and supervisory commitments pose a challenge towards his ability to grow his mentorship activities. This award will ensure Dr. Gutiérrez maintains the protected time to focus on POR related to disparities in CVD and CKD, a central component of which will involve mentoring junior investigators. His trainees will receive comprehensive training in POR centered on three main projects which focus on (1) the role of disordered mineral metabolism, (2) nutrition, (3) and novel pathways of kidney injury in explaining racial differences in CVD and CKD outcomes. This activities will be coupled with a robust program to enhance his skills as a mentor, with the ultimate goal of producing well-trained investigators committed to POR focused on disparities in health outcomes.

项目摘要 博士Gutiérrez是医学和流行病学副教授，结果和 肾内科流行病学研究，中心生物营养单元医学主任 在伯明翰的亚拉巴马大学（UAB）的临床和转化科学（CCTS）。很长的- 古铁雷斯博士的长期科学目标是建立一个以患者为导向的研究（POR）计划，重点是 确定减少或消除心血管疾病相关健康结果差异的新策略 疾病（CVD）和慢性肾病（CKD）。为了实现这一目标，古铁雷斯博士认识到， 指导下一代临床科学家的至关重要性，他们可以开发必要的 以全面和合乎道德的方式调查差异的根源。但 对他的时间越来越多的要求，以维持他的专业努力的研究，以及 行政和监督方面的工作对他的指导能力提出了挑战 活动该奖项将确保Gutiérrez博士保持受保护的时间专注于与以下相关的POR 心血管疾病和慢性肾脏病的差异，其中一个核心组成部分将涉及指导初级研究者。他 学员将接受全面的培训，在POR集中在三个主要项目，重点是（1） 矿物质代谢紊乱的作用，（2）营养，（3）和肾损伤的新途径在解释种族歧视中的作用。 CVD和CKD结果的差异。这些活动将与一个强有力的计划相结合，以提高他的 作为导师的技能，最终目标是培养训练有素的调查人员，致力于POR，重点是 健康结果的差异。