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Center for Clinical and Translational Science

临床和转化科学中心

基本信息

批准号：
10643722
负责人：
Orlando M Gutierrez
金额：
$ 777.61万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-06 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10643722
关键词：
Acceleration Accountability Active Learning Address Affect Alabama Bioinformatics Blood Vessels Clinical Clinical Data Clinical Informatics Clinical Research Clinical Sciences Clinical Trials Collaborations Communities Complement Consultations Data Analytics Dedications Deep South Development Disease Disparity Ecosystem Effectiveness Electronic Health Record Ensure Ethics Evaluation Feasibility Studies Fee Schedules Feedback Fostering Genomic medicine Goals Health Healthcare Systems Human Informatics Infrastructure Innovation Corps Institution International Investigation Knowledge Learning Louisiana Malignant Neoplasms Mentors Minority Groups Mission Mississippi Multi-Institutional Clinical Trial Patient Recruitments Performance Personal Satisfaction Population Precision therapeutics Process Productivity Public Health Reduce health disparities Research Research Design Resources Safety Science Services Special Population Thinking Training Training Programs Training and Education Translation Process Translational Research Translations Trust Universities Vision Work burden of illness cardiometabolism career clinical center community engagement data warehouse design digital fundamental research health care delivery health disparity improved innovation knowledge translation multidimensional data multidisciplinary next generation novel novel strategies novel therapeutics programs skills study population synergism tool translational impact translational pipeline underserved minority

项目摘要

Contact PD/PI: Kimberly, Robert P. ABSTRACT − OVERALL. The vision of the Center for Clinical and Translational Science (CCTS) is to reduce health disparities in diseases disproportionately represented within the Deep South as we accelerate discovery to improve human health. We have established a robust Partner Network – spanning Alabama, Mississippi and Louisiana – to ensure that our research and training efforts serve the special populations in our region while maximizing collaborative synergies in translational research to advance fundamental and clinical discovery through to application to human health and healthcare delivery. The CCTS will further the development of a vibrant, diverse clinical and translational research workforce (Aim 1) by providing education and training programs for learners at all career stages in support of innovative, multidisciplinary, engaged team research. We will continue to create and apply novel approaches in gamification, experiential learning, mentoring, and team-focused design thinking in I-Corps™ to convey new skills, perspectives and understanding of the translation process. We will catalyze collaborative, coordinated data analytics and informatics across the Partner Network and the CTSA consortium (Aim 2) by extending the digitally integrated ecosystem enabling full utilization of high dimensional data together with rich, deep clinical information to enable discovery research from the bench to the learning healthcare system. In keeping with our goal of reducing regional health disparities, we will expand the involvement of our communities in trusting, productive relationships and broadly engaged teams that advance knowledge to impactful implementation (Aim 3). We will work closely with local constituencies to address health issues of particular significance to our region and will share best practices in pursuit of community engaged studies to enhance culturally sensitive participation, safety, confidentiality and effectiveness. Toward the rapid and efficient translation of rigorously designed and effectively implemented clinical studies and trials (Aim 4), the CCTS Partner Network will support the ethical conduct of scientifically rigorous pilot and clinical research by providing a range of specialized services, resources and consultations. This effort will develop and will leverage innovative processes established by the CTSA Consortium and will promote the use of collaborative tools and processes that enable the rapid and efficient execution of multi-site clinical trials, taking advantage of the electronic health record to inform feasibility and access to study populations. Finally, we understand the importance of evaluating the CCTS activities to assure efficiency, quality and sustainability (Aim 5). We will use quantitative and qualitative assessment and feedback to assure that training and research programs meet the needs of its scientific constituencies and the goals of the CCTS, consistent with consortium-wide Common Metrics and Results Based Accountability evaluation activities. By achieving these aims, the CCTS Partner Network will accelerate clinical and translational research in the Deep South and advance the amelioration the significant health disparities faced by our populations. Page 459 Project Summary/Abstract Contact PD/PI: Kimberly, Robert P.

联系PD/PI：Kimberly，Robert P. 摘要-总体。临床和转化科学中心（CCTS）的愿景是减少随着我们加快发现，来改善人类健康。我们已经建立了一个强大的合作伙伴网络-覆盖亚拉巴马、密西西比和路易斯安那州-确保我们的研究和培训工作为我们地区的特殊人群服务同时最大限度地发挥转化研究的协同作用，从发现到应用到人类健康和医疗保健服务。CCTS将进一步推动通过提供教育，发展一支充满活力、多样化的临床和转化研究队伍（目标1）为所有职业阶段的学习者提供培训计划，以支持创新，多学科，敬业的团队 research.我们将继续创造和应用游戏化，体验式学习，指导和以团队为中心的设计思维，以传达新的技能，观点和理解的翻译过程。我们将促进整个行业的协作、协调的数据分析和信息学合作伙伴网络和CTSA联盟（目标2），通过扩展数字集成生态系统，充分利用高维数据和丰富、深入的临床信息，实现发现性研究从板凳到学习型医疗系统。为了实现我们的目标，我们将扩大我们社区的参与，建立信任，富有成效的关系，让团队参与进来，推动知识的有效实施（目标3）。我们将与当地政府密切合作，我们的合作伙伴将致力于解决对我们区域特别重要的卫生问题，并将分享以下方面的最佳做法：开展社区参与的研究，以加强对文化敏感的参与、安全、保密和有效性快速高效地翻译经过严格设计和有效实施的临床研究和试验（目标4），CCTS合作伙伴网络将支持科学的道德行为，通过提供一系列专业服务、资源和咨询，开展严格的试点和临床研究。这项工作将发展并利用CTSA联盟建立的创新流程，促进使用协作工具和流程，以便快速有效地执行多站点临床试验，利用电子健康记录来告知研究的可行性和访问权限人口。最后，我们理解评估CCTS活动以确保效率的重要性，质量和可持续性（目标5）。我们将使用定量和定性的评估和反馈，以确保培训和研究计划满足其科学赞助者的需求和CCTS的目标，与联合体范围内的共同责任制和基于成果的问责制评价活动相一致。通过为了实现这些目标，CCTS合作伙伴网络将加速深海领域的临床和转化研究，南方和促进改善我们人口面临的重大健康差距。第459页项目总结/摘要联系PD/PI：Kimberly，Robert P.