Center for Clinical and Translational Science

临床和转化科学中心

• 批准号: 10643722
• 负责人: Orlando M Gutierrez
• 金额: $ 777.61万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-06 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10643722
• 关键词: Acceleration; Accountability; Active Learning; Address; Affect; Alabama; Bioinformatics; Blood Vessels; Clinical; Clinical Data; Clinical Informatics; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Complement; Consultations; Data Analytics; Dedications; Deep South; Development; Disease; Disparity; Ecosystem; Effectiveness; Electronic Health Record; Ensure; Ethics; Evaluation; Feasibility Studies; Fee Schedules; Feedback; Fostering; Genomic medicine; Goals; Health; Healthcare Systems; Human; Informatics; Infrastructure; Innovation Corps; Institution; International; Investigation; Knowledge; Learning; Louisiana; Malignant Neoplasms; Mentors; Minority Groups; Mission; Mississippi; Multi-Institutional Clinical Trial; Patient Recruitments; Performance; Personal Satisfaction; Population; Precision therapeutics; Process; Productivity; Public Health; Reduce health disparities; Research; Research Design; Resources; Safety; Science; Services; Special Population; Thinking; Training; Training Programs; Training and Education; Translation Process; Translational Research; Translations; Trust; Universities; Vision; Work; burden of illness; cardiometabolism; career; clinical center; community engagement; data warehouse; design; digital; fundamental research; health care delivery; health disparity; improved; innovation; knowledge translation; multidimensional data; multidisciplinary; next generation; novel; novel strategies; novel therapeutics; programs; skills; study population; synergism; tool; translational impact; translational pipeline; underserved minority

Contact PD/PI: Kimberly, Robert P. ABSTRACT − OVERALL. The vision of the Center for Clinical and Translational Science (CCTS) is to reduce health disparities in diseases disproportionately represented within the Deep South as we accelerate discovery to improve human health. We have established a robust Partner Network – spanning Alabama, Mississippi and Louisiana – to ensure that our research and training efforts serve the special populations in our region while maximizing collaborative synergies in translational research to advance fundamental and clinical discovery through to application to human health and healthcare delivery. The CCTS will further the development of a vibrant, diverse clinical and translational research workforce (Aim 1) by providing education and training programs for learners at all career stages in support of innovative, multidisciplinary, engaged team research. We will continue to create and apply novel approaches in gamification, experiential learning, mentoring, and team-focused design thinking in I-Corps™ to convey new skills, perspectives and understanding of the translation process. We will catalyze collaborative, coordinated data analytics and informatics across the Partner Network and the CTSA consortium (Aim 2) by extending the digitally integrated ecosystem enabling full utilization of high dimensional data together with rich, deep clinical information to enable discovery research from the bench to the learning healthcare system. In keeping with our goal of reducing regional health disparities, we will expand the involvement of our communities in trusting, productive relationships and broadly engaged teams that advance knowledge to impactful implementation (Aim 3). We will work closely with local constituencies to address health issues of particular significance to our region and will share best practices in pursuit of community engaged studies to enhance culturally sensitive participation, safety, confidentiality and effectiveness. Toward the rapid and efficient translation of rigorously designed and effectively implemented clinical studies and trials (Aim 4), the CCTS Partner Network will support the ethical conduct of scientifically rigorous pilot and clinical research by providing a range of specialized services, resources and consultations. This effort will develop and will leverage innovative processes established by the CTSA Consortium and will promote the use of collaborative tools and processes that enable the rapid and efficient execution of multi-site clinical trials, taking advantage of the electronic health record to inform feasibility and access to study populations. Finally, we understand the importance of evaluating the CCTS activities to assure efficiency, quality and sustainability (Aim 5). We will use quantitative and qualitative assessment and feedback to assure that training and research programs meet the needs of its scientific constituencies and the goals of the CCTS, consistent with consortium-wide Common Metrics and Results Based Accountability evaluation activities. By achieving these aims, the CCTS Partner Network will accelerate clinical and translational research in the Deep South and advance the amelioration the significant health disparities faced by our populations. Page 459 Project Summary/Abstract Contact PD/PI: Kimberly, Robert P.

联系PD/PI：Kimberly，Robert P. 摘要 - 总体。临床与转化科学中心（CCT）的愿景是减少 当我们加速发现时，疾病的健康差异不成比例地表示 改善人类健康。我们已经建立了一个强大的合作伙伴网络 - 跨越阿拉巴马州，密西西比州 和路易斯安那州 - 确保我们的研究和培训工作为我们地区的特殊人群提供服务 同时最大程度地提高了转化研究中的协作协同作用，以提高基本和临床 发现对人类健康和医疗保健提供的应用。 CCT将进一步 通过提供教育来开发充满活力的，潜水员的临床和翻译研究人员（AIM 1） 以及在所有职业阶段为学习者的培训计划，以支持创新，多学科，参与的团队 研究。我们将继续创建和应用新颖的方法，在游戏化，经验丰富的学习中， I-Corps™中的指导和以团队为重点的设计思维，以传达新的技能，观点和理解 翻译过程。我们将催化整个过程中的协作，协调的数据分析和信息范围 合作伙伴网络和CTSA联盟（AIM 2）通过扩展数字集成的生态系统启用 充分利用高维数据以及丰富而深厚的临床信息，以实现发现研究 从板凳到学习医疗系统。符合我们减少区域健康的目标 差异，我们将扩大社区参与信任，产品关系和广泛的参与 参与将知识推向有影响力的实施的团队（AIM 3）。我们将与本地紧密合作 解决对我们地区特别重要的健康问题的选区，并将分享最佳实践 追求社区参与的研究，以增强文化敏感的参与，安全性，机密性和 效力。进行严格设计并有效实施的快速有效翻译 临床研究和试验（AIM 4），CCTS合作伙伴网络将支持科学的道德行为 通过提供一系列专业服务，资源和咨询，严格的飞行员和临床研究。 这项努力将发展并将利用CTSA财团建立的创新流程，并将 促进使用协作工具和流程，以快速有效地执行多站点 临床试验，利用电子健康记录来告知可行性和学习 人群。最后，我们了解评估CCT活动以确保效率的重要性， 质量和可持续性（目标5）。我们将使用定量和定性评估和反馈来确保 培训和研究计划满足其科学选区的需求以及CCT的目标， 与整个财团的通用指标和基于结果的问责制评估活动一致。经过 实现这些目标，CCTS合作伙伴网络将加速临床并翻译深度研究 南方并改善我们人口所面临的重大健康差异。 第459页 项目摘要/摘要 联系PD/PI：Kimberly，Robert P.

项目成果

Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease.

• DOI: 10.1167/iovs.62.9.13
• 发表时间: 2021-07-01
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Khanal S;Bai Y;Ngo W;Nichols KK;Wilson L;Barnes S;Nichols JJ
• 通讯作者: Nichols JJ

Consensus molecular subtype differences linking colon adenocarcinoma and obesity revealed by a cohort transcriptomic analysis.

• DOI: 10.1371/journal.pone.0268436
• 发表时间: 2022
• 期刊: PloS one
• 影响因子: 3.7

Sleep, screen time, and family meal frequency in preschool children: A pilot study.

学龄前儿童的睡眠、屏幕时间和家庭进餐频率：一项试点研究。

• DOI: 10.1097/01.npr.0000681788.13417.56
• 发表时间: 2020
• 期刊: The Nurse practitioner
• 作者: Hayes,Katey;Williams,SusanG;Fruh,Sharon;Graves,RebeccaJ;Minchew,LeighA;Hall,HeatherR
• 通讯作者: Hall,HeatherR

Short-term high-salt consumption does not influence resting or exercising heart rate variability but increases MCP-1 concentration in healthy young adults.

短期高盐摄入不会影响静息或运动心率变异性，但会增加健康年轻人的 MCP-1 浓度。

• DOI: 10.1152/ajpregu.00240.2022
• 发表时间: 2023
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Linder,BraxtonA;Babcock,MatthewC;Pollin,KamilaU;Watso,JosephC;Robinson,AustinT
• 通讯作者: Robinson,AustinT

Adjusting for muscle strength and body size attenuates sex differences in the exercise pressor reflex in young adults.

调整肌肉力量和体型可以减弱年轻人运动升压反射的性别差异。

• DOI: 10.1152/ajpheart.00151.2023
• 发表时间: 2023
• 期刊: American journal of physiology. Heart and circulatory physiology
• 作者: Tharpe,McKennaA;Linder,BraxtonA;Babcock,MatthewC;Watso,JosephC;Pollin,KamilaU;Hutchison,ZachJ;Barnett,AlexM;Culver,MeralN;Kavazis,AndreasN;Brian,MichaelS;Robinson,AustinT
• 通讯作者: Robinson,AustinT