Mentored patient-oriented research in disparities in cardiovascular and kidney disease

项目总结 古铁雷斯博士是医学和流行病学副教授，成果和流行病学科长 肾脏病学部流行病学研究，中心生物营养科医学主任 阿拉巴马大学伯明翰分校(UAB)临床与转化科学(CCTS)。长的- 古铁雷斯博士的长期科学目标是建立一个以患者为导向的研究(POR)计划，专注于 确定减少或消除与心血管疾病相关的健康结果差异的新战略 心血管疾病(CVD)和慢性肾脏疾病(CKD)。为了实现这一目标，古铁雷斯博士认识到 指导下一代临床医生科学家的至关重要，他们能够开发出必要的 以全面和合乎道德的方式调查差异的根本原因的专门知识。然而， 对他的时间要求越来越高，这与他在研究方面的专业努力以及 行政和监督承诺对他成长为导师的能力构成了挑战 活动。这一奖项将确保古铁雷斯博士保持受保护的时间，专注于与 CVD和CKD之间的差距，其中的一个核心组成部分将涉及指导初级调查人员。他的 学员将接受以三个主要项目为中心的POR综合培训，这三个项目侧重于(1) 矿物质代谢紊乱的作用，(2)营养，(3)和肾脏损伤的新途径在解释种族 CVD和CKD结局的差异。这项活动将与一个强有力的计划相结合，以加强他的 作为导师的技能，最终目标是培养训练有素的调查人员，致力于POR 在健康结果方面的差异。

PROJECT SUMMARY Dr. Gutiérrez is an Associate Professor of Medicine and Epidemiology, Section Head of Outcomes and Epidemiology research in the Division of Nephrology, and Medical Director of the Bionutrition Unit in the Center for Clinical and Translational Science (CCTS) at the University of Alabama at Birmingham (UAB). The long- term scientific goal of Dr. Gutiérrez is to build a patient-oriented research (POR) program focused on identifying novel strategies for reducing or eliminating disparities in health outcomes related to cardiovascular disease (CVD) and chronic kidney disease (CKD). In order to accomplish this goal, Dr. Gutiérrez recognizes the critical importance of mentoring the next generation of clinician scientists who can develop the necessary expertise to investigate root causes of disparities in a comprehensive and ethical manner. However, the increasing demands on his time related to sustaining his professional effort for research as well as administrative and supervisory commitments pose a challenge towards his ability to grow his mentorship activities. This award will ensure Dr. Gutiérrez maintains the protected time to focus on POR related to disparities in CVD and CKD, a central component of which will involve mentoring junior investigators. His trainees will receive comprehensive training in POR centered on three main projects which focus on (1) the role of disordered mineral metabolism, (2) nutrition, (3) and novel pathways of kidney injury in explaining racial differences in CVD and CKD outcomes. This activities will be coupled with a robust program to enhance his skills as a mentor, with the ultimate goal of producing well-trained investigators committed to POR focused on disparities in health outcomes.