Molecular Mechanisms of Seasonal Time Measurement
季节时间测量的分子机制
基本信息
- 批准号:10226082
- 负责人:
- 金额:$ 32.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-04-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:ATAC-seqAmino AcidsAnimal ModelAnimalsArabidopsisBehaviorBiochemicalCardiovascular systemCellsCharacteristicsChromatinChronobiologyCompanionsCrystallizationDevelopmentDiseaseEnvironmentFailureFlowersGenesGenetic TranscriptionGoalsGrowthHomeostasisHumanImmunityKnowledgeLearningLengthLightMammalsMeasurementMeasuresMemoryMetabolismModelingMolecularNatureOrganismOutputPhotoperiodPhotoreceptorsPhylogenetic AnalysisPhysiologicalPhysiologyPlant LeavesPlant ModelPlantsProceduresProcessPropertyQuality of lifeRegulationReproductionResearchScheduleSeasonal Affective DisorderSeasonsSignal TransductionStimulusStructureSystemTemperatureTimeTissuesTranscriptional RegulationTranslatingVariantWorkcell typecircadian pacemakerday lengthdifferential expressionepigenomicsexperimental studygenomic toolsimprovedinsightmolecular clockoptogeneticsphloemphotoperiodicityphyA phytochromeprogramsreproductiveresponsespatiotemporaltemporal measurementtooltranscription factortranscriptometranscriptomics
项目摘要
PROJECT SUMMARY/ABSTRACT
Failure to respond to seasonal change has severe consequences for an organism’s ability to survive and
reproduce. For humans, seasonal oscillation in the surrounding environment, especially the amount of light,
can cause Seasonal Affective Disorder, as well as cardiovascular and immunity-related diseases. In animals
and plants, reproduction is precisely aligned with specific seasons. Many organisms, including humans, have
evolved sensing mechanisms to prepare for upcoming seasonal changes by adjusting homeostasis, physiology
and development. The long-term goal of our research program is to elucidate the molecular mechanisms by
which organisms measure seasonal changes, particularity in day length and temperature. Although we know
that the interplay between external stimuli (light and temperature) and the internal circadian clock orchestrates
seasonal responses, the molecular regulatory networks involved have remained largely elusive. Seasonal time
measurement has been one of the important topics in chronobiology for decades, and we have learned that
similar types or structures of these networks exist in both animals and plants. Among the model organisms
used in this research, our knowledge of the model plant Arabidopsis is the most advanced. In Arabidopsis,
ambient light and temperature differences are processed through the molecular clock network to regulate the
transcription of a florigen (flower-inducing) gene called FLOWERING LOCUS T (FT). Our major focus is
elucidating how FT transcription is regulated. Although the circadian clock-dependent seasonal sensing
mechanism is the major controller of FT expression, other external and internal information is channeled into
the regulation of FT transcription to precisely determine the timing of flowering. In Aim 1 of this proposal, we
will obtain more precise epigenomic and transcriptomic information in both FT-expressing cells and cells that
do not express FT at the tissue/cell-type levels. With this information, we will be able to organize our current
understanding of FT regulation at the whole plant level into more precise tissue/cell-type specific regulation.
Through our study of plants grown in nature, we recently found an FT transcription regulation controlled by light
and the circadian clock that had been completely uncharacterized up to this point. We will study the molecular
mechanisms underlying this regulation in Aim 2. Our work in seasonal sensing mechanisms has provided
functional knowledge about the photoreceptor FKF1. In Aim 3, we will obtain more precise knowledge about
how this photoreceptor is built by tuning the length of light-excited states and analyzing changes in biochemical
output function. This information will help us understand how the photochemical features of this photoreceptor
control functional outputs; it will also likely provide us with more optogenetic tools. The findings will have a
large impact on plant research and our broader understanding of seasonal sensing and circadian clocks in
mammals and other systems, including humans.
项目总结/摘要
未能对季节变化作出反应会对生物体的生存能力造成严重后果,
繁殖。对于人类来说,周围环境的季节性波动,尤其是光照量,
可能导致季节性情感障碍,以及心血管和免疫相关疾病。动物中
而植物的繁殖则与特定的季节紧密相连。许多生物,包括人类,
进化的感知机制,通过调整体内平衡,生理学,
发展先行者的要求我们的研究计划的长期目标是阐明分子机制,
这种生物测量季节变化,特别是白天的长度和温度。虽然我们知道
外部刺激(光和温度)和内部生物钟之间的相互作用
季节性反应,所涉及的分子调控网络在很大程度上仍然难以捉摸。季节性时间
几十年来,测量一直是时间生物学的重要主题之一,我们了解到,
动物和植物中都存在类似类型或结构的这些网络。在模式生物中,
在本研究中,我们对模式植物拟南芥的了解是最先进的。在拟南芥中,
通过分子时钟网络处理环境光和温度差,
转录的成花素(花诱导)基因称为FLOWERLOCUS T(FT)。我们的重点是
阐明FT转录是如何被调节的。虽然生物钟依赖的季节感测
机制是FT表达的主要控制者,其他外部和内部信息被导入
调节FT转录以精确确定开花时间。在本建议的目标1中,我们
将在表达FT的细胞和
在组织/细胞类型水平上不表达FT。有了这些信息,我们将能够组织我们目前的
在整个植物水平上理解FT调节为更精确的组织/细胞类型特异性调节。
通过我们对自然界中生长的植物的研究,我们最近发现了一种受光控制的FT转录调节
和生物钟之间的联系,到目前为止还完全没有被描述出来。我们将研究
目标2中的这种调节机制。我们在季节感应机制方面的工作提供了
光感受器FKF 1的功能知识。在目标3中,我们将获得关于
如何通过调整光激发态的长度和分析生物化学的变化来构建这种感光器
输出函数这些信息将帮助我们了解这种光感受器的光化学特征
控制功能输出;它也可能为我们提供更多的光遗传学工具。调查结果将有一个
对植物研究的巨大影响以及我们对季节感测和生物钟的更广泛理解,
哺乳动物和其他系统,包括人类。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
TAKATO IMAIZUMI其他文献
TAKATO IMAIZUMI的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('TAKATO IMAIZUMI', 18)}}的其他基金
Molecular Mechanisms of Seasonal Time Measurement
季节时间测量的分子机制
- 批准号:
10457296 - 财政年份:2007
- 资助金额:
$ 32.46万 - 项目类别:
Molecular Mechanism of Photoperiodic Time Measurement
光周期时间测量的分子机制
- 批准号:
7791317 - 财政年份:2007
- 资助金额:
$ 32.46万 - 项目类别:
Molecular Mechanism of Photoperiodic Time Measurement
光周期时间测量的分子机制
- 批准号:
8503273 - 财政年份:2007
- 资助金额:
$ 32.46万 - 项目类别:
Molecular Mechanism of Photoperiodic Time Measurement
光周期时间测量的分子机制
- 批准号:
7268264 - 财政年份:2007
- 资助金额:
$ 32.46万 - 项目类别:
Molecular Mechanism of Photoperiodic Time Measurement
光周期时间测量的分子机制
- 批准号:
7596474 - 财政年份:2007
- 资助金额:
$ 32.46万 - 项目类别:
Molecular Mechanism of Photoperiodic Time Measurement
光周期时间测量的分子机制
- 批准号:
7547634 - 财政年份:2007
- 资助金额:
$ 32.46万 - 项目类别:
Molecular Mechanism of Photoperiodic Time Measurement
光周期时间测量的分子机制
- 批准号:
7714787 - 财政年份:2007
- 资助金额:
$ 32.46万 - 项目类别:
Molecular Mechanism of Photoperiodic Time Measurement
光周期时间测量的分子机制
- 批准号:
8044686 - 财政年份:2007
- 资助金额:
$ 32.46万 - 项目类别:
Molecular Mechanisms of Seasonal Time Measurement
季节时间测量的分子机制
- 批准号:
9816343 - 财政年份:2007
- 资助金额:
$ 32.46万 - 项目类别:
Molecular Mechanism of Photoperiodic Time Measurement
光周期时间测量的分子机制
- 批准号:
9043103 - 财政年份:2007
- 资助金额:
$ 32.46万 - 项目类别:
相似海外基金
Double Incorporation of Non-Canonical Amino Acids in an Animal and its Application for Precise and Independent Optical Control of Two Target Genes
动物体内非规范氨基酸的双重掺入及其在两个靶基因精确独立光学控制中的应用
- 批准号:
BB/Y006380/1 - 财政年份:2024
- 资助金额:
$ 32.46万 - 项目类别:
Research Grant
Quantifying L-amino acids in Ryugu to constrain the source of L-amino acids in life on Earth
量化 Ryugu 中的 L-氨基酸以限制地球生命中 L-氨基酸的来源
- 批准号:
24K17112 - 财政年份:2024
- 资助金额:
$ 32.46万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Molecular recognition and enantioselective reaction of amino acids
氨基酸的分子识别和对映选择性反应
- 批准号:
23K04668 - 财政年份:2023
- 资助金额:
$ 32.46万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Basic research toward therapeutic strategies for stress-induced chronic pain with non-natural amino acids
非天然氨基酸治疗应激性慢性疼痛策略的基础研究
- 批准号:
23K06918 - 财政年份:2023
- 资助金额:
$ 32.46万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular mechanisms how arrestins that modulate localization of glucose transporters are phosphorylated in response to amino acids
调节葡萄糖转运蛋白定位的抑制蛋白如何响应氨基酸而被磷酸化的分子机制
- 批准号:
23K05758 - 财政年份:2023
- 资助金额:
$ 32.46万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Design and Synthesis of Fluorescent Amino Acids: Novel Tools for Biological Imaging
荧光氨基酸的设计与合成:生物成像的新工具
- 批准号:
2888395 - 财政年份:2023
- 资助金额:
$ 32.46万 - 项目类别:
Studentship
Collaborative Research: RUI: Elucidating Design Rules for non-NRPS Incorporation of Amino Acids on Polyketide Scaffolds
合作研究:RUI:阐明聚酮化合物支架上非 NRPS 氨基酸掺入的设计规则
- 批准号:
2300890 - 财政年份:2023
- 资助金额:
$ 32.46万 - 项目类别:
Continuing Grant
Structurally engineered N-acyl amino acids for the treatment of NASH
用于治疗 NASH 的结构工程 N-酰基氨基酸
- 批准号:
10761044 - 财政年份:2023
- 资助金额:
$ 32.46万 - 项目类别:
Lifestyle, branched-chain amino acids, and cardiovascular risk factors: a randomized trial
生活方式、支链氨基酸和心血管危险因素:一项随机试验
- 批准号:
10728925 - 财政年份:2023
- 资助金额:
$ 32.46万 - 项目类别:
Single-molecule protein sequencing by barcoding of N-terminal amino acids
通过 N 端氨基酸条形码进行单分子蛋白质测序
- 批准号:
10757309 - 财政年份:2023
- 资助金额:
$ 32.46万 - 项目类别: