Self-driven women's health equity through an innovative, inclusive, AI-driven and evidence-led decentralised precision medicine platform for awareness, diagnosis, and management of menopause.

通过创新、包容、人工智能驱动和证据主导的去中心化精准医疗平台，实现更年期意识、诊断和管理，自我驱动的女性健康公平。

• 批准号: 10043563
• 金额: $ 6.36万
• 依托单位: TARACARES LTD
• 依托单位国家: 英国
• 项目类别: Grant for R&D
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10043563
• 关键词: Self; driven; women; health; equity

Menopause is a significant and inevitable transition of a woman's reproductive life span. The average age of menopause in the UK is 51 in contrast to 46 in India and other countries with developing and low-income economies. There are 700 million women globally undergoing this transition. In the UK the number is 14 million while in India more than 100 million women are above the age of 50\. The increase in average life expectancy and female workforce has shifted reproductive decisions to later childbearing years. The psychological and mental health consequences from menopause leads to a deterioration of health-related quality of life and economic loss of the productive workforce. Per the economic impact of menopause published by the UK government in 2017, 47% of the UK workforce -- i.e., all female workers - will experience menopause transition during their working lives.Menopause experience is heterogenous requiring individualised and contextual knowledge for creating scientific and evidence-led awareness, diagnosis, and management. Little is known about Premature Ovarian Insufficiency, surgical, and medically induced situations that have the same effect on the functioning of a woman's reproductive system as natural menopause which is an age-related natural developmental stage. Psychological, physiological, as well as socio-economic factors including lifestyle choices, long-term health conditions and medication history need to be investigated to make accurate decisions for diagnosis and management. The lack of clinical expertise, gaps in fundamental medical training and years of specialised clinical practice for accurate diagnosis and recommendation makes this an insurmountable public health challenge.Hormonal replacement is being offered as the most popular therapy with little knowledge on long-term consequences that may ultimately increase the healthcare cost burdens. Moreover, not every woman can take or prefers to take hormone replacement. Limited scientific evidence exists on the hormone profile alteration consequences in transmasculine and non-binary individuals who may undergo menopause transition in some measure.Through this project we are uniting advanced computational science (AI), clinical excellence, and academic research to create prediction models for awareness, diagnosis, and management of menopause through a personalised healthcare platform infrastructure that allows for a continuous feedback loop between patients and clinicians. This can be deployed in a range of settings such as General Practice, Community health hubs, Menopause clinics, Telehealth clinics thereby decentralising healthcare and offering a sustainable business and healthcare model for self-driven health equity for women's health making a step-change in closing health inequalities.

更年期是女性生殖寿命的一个重要且不可避免的转变。英国的平均绝经年龄为 51 岁，而印度和其他发展中国家和低收入经济体的绝经年龄为 46 岁。全球有 7 亿女性正在经历这一转变。在英国，这一数字为 1400 万，而在印度，超过 1 亿女性年龄在 50 岁以上。平均预期寿命和女性劳动力的增加已将生育决策转移到较晚的育龄期。更年期造成的心理和精神健康后果导致与健康相关的生活质量恶化和生产劳动力的经济损失。根据英国政府 2017 年发布的更年期经济影响，47% 的英国劳动力（即所有女性工人）将在其工作生涯中经历更年期过渡。更年期经历是多种多样的，需要个性化和背景知识来建立科学和证据导向的意识、诊断和管理。人们对卵巢早衰、手术和药物引起的情况知之甚少，这些情况对女性生殖系统功能的影响与自然更年期（与年龄相关的自然发育阶段）具有相同的影响。需要调查心理、生理以及社会经济因素，包括生活方式选择、长期健康状况和用药史，以便做出准确的诊断和治疗决策。缺乏临床专业知识、基础医学培训方面的差距以及多年的准确诊断和建议的专业临床实践，使得这一问题成为一项难以克服的公共卫生挑战。激素替代疗法作为最受欢迎的疗法而被提供，但对可能最终增加医疗费用负担的长期后果知之甚少。此外，并非每个女性都可以服用或喜欢服用激素替代疗法。对于可能在某种程度上经历更年期过渡的跨男性和非二元个体的激素谱改变后果，科学证据有限。通过这个项目，我们将先进的计算科学 (AI)、临床卓越和学术研究结合起来，通过个性化的医疗平台基础设施创建更年期意识、诊断和管理的预测模型，该基础设施允许患者和临床医生之间的持续反馈循环。这可以部署在全科诊所、社区健康中心、更年期诊所、远程医疗诊所等一系列环境中，从而分散医疗保健，并为女性健康的自我驱动健康公平提供可持续的商业和医疗保健模式，从而在消除健康不平等方面迈出一步。