Data-driven, peer-led messaging using social media influencers to increase PrEP awareness and uptake among transgender women

项目摘要 变性人女性感染艾滋病毒的风险明显较高，但研究表明，她们感染艾滋病毒的风险较低 可能使用暴露前预防措施(PrEP)，并继续对其效用存在误解。转接- 由受信任的同行提供的包容性通信是弥补这一差距的潜在有用战略，但 接触到大量的TW可能是困难的。SIS(姐妹影响姐妹)研究将使用 来自NIMH资助的R21的初步发现，该R21利用了商业营销技术 映射和矢量消息建模，以开发和概念测试TW特定PrEP消息。使用 以性别肯定框架和EPIS实施框架为指导，我们建议嵌入 这些人在SIS干预中测试PrEP信息和材料，并使用TW社会影响者(SIS)进行试点 通过Instagram。研究的具体目标是：目标1：设计一个社区主导的、以社交媒体为基础的PrEP TW SIS的报文传送培训。我们将招募一个社区咨询委员会(CAB)，它将就所有 研究的各个方面，包括制定SI培训和招聘SIS、工具/措施、 研究结果的传播，以及对未来试验的投入。目标2：完善PrEP消息材料，设计SIS 干预模块，并识别和培训TW SIS。我们将最终确定PrEP消息传递材料， 变性人艺术家可以优化图像并转换为社交媒体格式。在我们出租车的帮助下，我们将识别和 从两个干预地点(旧金山湾、费城)和两个地点在社交媒体上与SIS接触 比较地点(纽约和洛杉矶)。干预SIS将接受有关SIS干预的培训 内容以及向其社区提供临床转诊和资源。目标3：目标3：试点测试 SIS干预，收集可行性、可接受性和初步疗效数据，为全面试验提供信息。我们 将实施基于Instagram的干预的标准化核心组件，评估传播和 了解PrEP信息的传播范围，并监控和评估材料的参与度。评估…的前景 有效性，我们将确定一个由120名追随者(80名干预，40名对照)组成的队列来完成基线、中期和 结束干预调查，以跟踪变化并比较PrEP知识和PrEP认知水平。我们 还将试点远程采集头发样本，以监测PrEP在部分参与者中的吸收和使用 (n=30；每组5例)并进行深入干预实施评估。我们预计调查结果将 对我们了解如何与不同的TW团队进行沟通、如何利用 社交媒体作为一种强大的沟通渠道，以及如何传播信息以提高PrEP 通过解决TW独特的艾滋病毒预防需求和关切，提高认识和认识。

Project Summary Transgender women (TW) are at significantly higher risk of getting HIV, yet research indicates they are less likely to use pre exposure prophylaxis (PrEP) and continue to have misconceptions about its utility. Trans- inclusive communication, delivered by trusted peers, is a potentially useful strategy to address this gap, but reaching a large number of TW can be difficult. The SIS (Sisters Influencing Sisters) study will use preliminary findings from a NIMH funded R21 that utilized commercial marketing techniques called perceptual mapping and vector message modeling to develop and concept test TW specific PrEP messages. Using the Gender Affirmation Framework and the EPIS Implementation Framework as guides, we propose to embed these tested PrEP messages and materials in the SIS intervention and pilot it using TW social influencers (SIs) via Instagram. Specific aims of the research are: Aim 1: Design a community-led, social-media based PrEP messaging training for TW SIs. We will recruit a Community Advisory Board (CAB) who will consult on all aspects of the study, including the development of an SI training and recruitment of SIs, tools/measures, dissemination of findings, and input on a future trial. Aim 2: Refine PrEP messaging materials, design the SIS intervention modules, and identify and train TW SIs. We will finalize PrEP messaging materials, engaging trans artists to refine images and convert to social media formats. With the help of our CAB, we will identify and engage SIs on social media from two intervention locations (San Francisco Bay, Philadelphia) and two comparison locations (New York and Los Angeles). Intervention SIs will be trained on the SIS intervention content as well as delivery of clinical referrals and resources to their communities. Aim 3: Aim 3: Pilot test the SIS intervention to collect feasibility, acceptability, and preliminary efficacy data to inform a full trial. We will implement standardized core components of the Instagram-based intervention, evaluate dissemination and reach of the PrEP messages, and monitor and evaluate engagement with the materials. To assess promise of efficacy, we will identify a cohort of 120 followers (80 intervention, 40 comparison) to complete baseline, mid and end of intervention surveys to track changes and compare levels of PrEP knowledge and PrEP perceptions. We will also pilot remote collection of hair samples to monitor PrEP uptake and use in a subsample of participants (n=30; 5 each SI) and do in-depth intervention implementation evaluation. We expect that findings will significantly contribute to our understanding of how to communicate with a diverse group of TW, how to leverage social media as a powerful communication channel, and how to disseminate information to increase PrEP awareness and uptake by addressing the unique HIV prevention needs and concerns of TW.