Biostatistics Core

项目摘要 卵巢孢子生物统计核心将为所有三个提供统计和计算支持 卵巢癌的治疗该核心还将为病理学核心、类器官、模型 系统和生物标志物的核心和发展项目。这一核心将联合设在 马萨诸塞州总医院（MGH）生物统计中心和Dana-Farber癌症数据部 Dana Farber癌症研究所（DFCI）核心董事Nabihah Tayob博士和Steven博士 Skates将带来实验设计、临床前和临床研究所需的统计专业知识， 以及数据收集、管理、整合和质量控制。核心确定了五个关键领域 核心成员将与项目调查人员和核心领导人合作， 和全面的生物统计学支持整个卵巢孢子。生物统计学的主要作用 核心是提供生物统计学专业知识，用于设计，实施，监测，分析和报告 实验室、动物、转化、临床研究，包括SPORE项目的相关研究， 发展研究和职业发展项目，以及其他核心。生物统计学核心还将 提供数据收集方面的输入，并协助SPORE研究者协调实验室结果， 临床研究或临床/转化研究数据库的结果，提供短期生物统计学 为整个SPORE研究小组提供咨询，协助评估发展研究， 职业提升计划，并与SPORE调查人员合作开发新的统计方法， 解决卵巢癌研究中出现的问题，因为没有标准的方法。

Project Summary The ovarian SPORE Biostatistics Core will provide the statistical and computational support for all three Ovarian Cancer SPORE Projects. This core will also provide support for the Pathology Core, Organoids, Model Systems, and Biomarkers Core and Developmental Projects. This Core will be jointly based at the Massachusetts General Hospital (MGH) Biostatistics Center and Dana-Farber Cancer the Department of Data Sciences at Dana Farber Cancer Institute (DFCI). The Core Directors, Dr. Nabihah Tayob and Dr. Steven Skates, will bring in statistical expertise required for experimental design, pre-clinical and clinical studies, as well as data collection, management, integration, and quality control. The core has identified five key areas where the members of the core will collaborate with project investigators and core leaders to ensure integrated and comprehensive biostatistical support to the entire Ovarian SPORE. The primary role of the Biostatistics Core is to provide biostatistics expertise for the design, conduct, monitoring, analysis, and reporting of laboratory, animal, translational, clinical studies, including associated correlative studies for SPORE Projects, Developmental Research and Career Enhancement Projects, and other Cores. The Biostatistics Core will also provide input on data collection and assist SPORE investigators in coordinating laboratory results with outcomes from clinical studies or clinical/translational research databases, provide short-term biostatistics consulting to the entire group of SPORE researchers, assist in the evaluation of Developmental Research and Career Enhancement Programs and work with SPORE investigators to develop new statistical methods to address problems arising in ovarian cancer research for which no standard methodologies are available.