Biostatistics Core

生物统计学核心

• 批准号: 10228049
• 负责人: Steven J Skates
• 金额: $ 29.52万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-03 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10228049
• 关键词: Address; Area; Biological Markers; Biological Models; Biometry; Biostatistics Core; Cancer Center; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Computer software; Consult; Consultations; Correlative Study; Dana-Farber Cancer Institute; Data; Data Analyses; Data Collection; Data Science; Databases; Development; Ensure; Evaluation; Experimental Designs; General Hospitals; Grant; Human Resources; Laboratories; Laboratory Animals; Malignant Neoplasms; Malignant neoplasm of ovary; Massachusetts; Methodology; Methods; Mission; Monitor; Organoids; Outcome; Ovarian; Pathology; Process; Quality Control; Reporting; Research; Research Personnel; Role; Skates; Statistical Methods; Training; Translational Research; Work; anticancer research; base; career; data management; data quality; design; interest; laboratory experiment; member; mid-career faculty; preclinical study; programs; quality assurance; statistics

Project Summary The ovarian SPORE Biostatistics Core will provide the statistical and computational support for all three Ovarian Cancer SPORE Projects. This core will also provide support for the Pathology Core, Organoids, Model Systems, and Biomarkers Core and Developmental Projects. This Core will be jointly based at the Massachusetts General Hospital (MGH) Biostatistics Center and Dana-Farber Cancer the Department of Data Sciences at Dana Farber Cancer Institute (DFCI). The Core Directors, Dr. Nabihah Tayob and Dr. Steven Skates, will bring in statistical expertise required for experimental design, pre-clinical and clinical studies, as well as data collection, management, integration, and quality control. The core has identified five key areas where the members of the core will collaborate with project investigators and core leaders to ensure integrated and comprehensive biostatistical support to the entire Ovarian SPORE. The primary role of the Biostatistics Core is to provide biostatistics expertise for the design, conduct, monitoring, analysis, and reporting of laboratory, animal, translational, clinical studies, including associated correlative studies for SPORE Projects, Developmental Research and Career Enhancement Projects, and other Cores. The Biostatistics Core will also provide input on data collection and assist SPORE investigators in coordinating laboratory results with outcomes from clinical studies or clinical/translational research databases, provide short-term biostatistics consulting to the entire group of SPORE researchers, assist in the evaluation of Developmental Research and Career Enhancement Programs and work with SPORE investigators to develop new statistical methods to address problems arising in ovarian cancer research for which no standard methodologies are available.

项目概要 卵巢 SPORE 生物统计核心将为所有三个提供统计和计算支持 卵巢癌孢子项目。该核心还将为病理学核心、类器官、模型提供支持 系统和生物标志物核心和开发项目。该核心将联合设在 马萨诸塞州总医院 (MGH) 生物统计中心和 Dana-Farber 癌症数据部 达纳法伯癌症研究所 (DFCI) 的科学研究。核心董事 Nabihah Tayob 博士和 Steven 博士 Skates 将引入实验设计、临床前和临床研究所需的统计专业知识，因为 以及数据收集、管理、集成和质量控制。核心确定了五个重点领域 核心成员将与项目调查员和核心领导者合作，以确保一体化 以及对整个卵巢孢子的全面生物统计支持。生物统计学的主要作用 核心是提供生物统计学专业知识，用于设计、实施、监测、分析和报告 实验室、动物、转化、临床研究，包括 SPORE 项目的相关研究， 发展研究和职业提升项目以及其他核心。生物统计学核心还将 提供数据收集方面的意见并协助 SPORE 研究人员与实验室协调结果 临床研究或临床/转化研究数据库的结果，提供短期生物统计数据 向整个 SPORE 研究人员小组提供咨询，协助评估发展研究和 职业提升计划并与 SPORE 研究人员合作开发新的统计方法 解决卵巢癌研究中出现的没有标准方法的问题。