Biostatistics Core

项目摘要 卵巢孢子生物统计核心将为这三个项目提供统计和计算支持 卵巢癌孢子项目。这个核心还将为病理学核心、有机物质、模型提供支持 系统，以及生物标志物核心和发展项目。该核心将联合总部设在 马萨诸塞州总医院(MGH)生物统计中心和Dana-Farber癌症数据部 达纳·法伯癌症研究所(DFCI)的理科博士。核心董事，Nabihah Tayob博士和Steven博士 将带来实验设计、临床前和临床研究所需的统计专业知识，如 以及数据收集、管理、集成和质量控制。核心确定了五个关键领域 在那里，核心成员将与项目调查人员和核心领导人合作，以确保 以及对整个卵巢孢子的全面生物统计学支持。生物统计学的主要作用 核心是为设计、实施、监测、分析和报告提供生物统计学专业知识 实验室、动物、翻译、临床研究，包括与孢子项目相关的研究， 发展研究和职业提升项目，以及其他核心。生物统计核心也将 提供数据收集方面的信息，并协助孢子调查人员协调实验室结果 临床研究或临床/转化性研究数据库的结果，提供短期生物统计 咨询整个孢子研究小组，协助评估发展研究和 职业提升计划和与孢子调查人员合作开发新的统计方法 解决卵巢癌研究中出现的问题，这些问题没有标准的方法可用。

Project Summary The ovarian SPORE Biostatistics Core will provide the statistical and computational support for all three Ovarian Cancer SPORE Projects. This core will also provide support for the Pathology Core, Organoids, Model Systems, and Biomarkers Core and Developmental Projects. This Core will be jointly based at the Massachusetts General Hospital (MGH) Biostatistics Center and Dana-Farber Cancer the Department of Data Sciences at Dana Farber Cancer Institute (DFCI). The Core Directors, Dr. Nabihah Tayob and Dr. Steven Skates, will bring in statistical expertise required for experimental design, pre-clinical and clinical studies, as well as data collection, management, integration, and quality control. The core has identified five key areas where the members of the core will collaborate with project investigators and core leaders to ensure integrated and comprehensive biostatistical support to the entire Ovarian SPORE. The primary role of the Biostatistics Core is to provide biostatistics expertise for the design, conduct, monitoring, analysis, and reporting of laboratory, animal, translational, clinical studies, including associated correlative studies for SPORE Projects, Developmental Research and Career Enhancement Projects, and other Cores. The Biostatistics Core will also provide input on data collection and assist SPORE investigators in coordinating laboratory results with outcomes from clinical studies or clinical/translational research databases, provide short-term biostatistics consulting to the entire group of SPORE researchers, assist in the evaluation of Developmental Research and Career Enhancement Programs and work with SPORE investigators to develop new statistical methods to address problems arising in ovarian cancer research for which no standard methodologies are available.