Midcareer Investigator Award in Patient-Oriented Research in Pediatric Rare Lung Diseases

本申请的总体目标是在以患者为导向的研究中获得职业中期研究者奖， 使杨博士能够在以患者为导向的研究中建立和扩大她的研究和指导计划， 小儿罕见肺部疾病。罕见肺部疾病包括一大组与高血压相关的疾病。 儿童的发病率，有时甚至死亡率。候选人是罕见的临床护理和研究专家 肺部疾病，这一奖项将使她专注于进一步发展（1）以患者为导向的研究 儿科罕见肺病项目旨在促进对疾病发病机制的理解， 治疗方法，和（2）辅导计划，以促进新的研究人员的职业发展。 该奖项将允许候选人有受保护的时间专门用于发展辅导技能 在她的学员谁是研究员和初级教员面向病人的研究，并扩大 她的指导范围包括新的博士后学员和医学生。通过这个奖项博士。 杨将参加正在进行的教育活动，以提高她作为导师的技能，并发展 加强临床研究技能，重点是基因组学和罕见疾病。这些研究利用了一个平台 用于儿科罕见肺部疾病的以患者为导向的研究，以及目前资助的一系列研究 项目此外，杨博士在以病人为导向的研究计划将扩大在新的和新颖的 方向具体来说，她将利用现有的NHLBI资助的研究项目，重点确定 罕见儿童间质性肺病预后的遗传机制和可改变的预测因子这 该奖项将使杨博士能够大大推进儿科罕见肺部疾病领域，并提高她的 指导技能，以确保对未来一代以患者为导向的研究人员进行强有力的培训。

The overall goal of this application for a Midcareer Investigator Award in Patient-Oriented Research is to enable Dr. Young to build and expand her research and mentoring programs in patient-oriented research in Pediatric Rare Lung Diseases. Rare Lung Diseases comprise a large group of disorders associated with high morbidity and sometimes mortality in children. The candidate is an expert in clinical care and research in rare lung diseases, and this award will allow her to focus on further development of (1) a patient-oriented research program in pediatric rare lung diseases aimed to advance understanding of disease pathogenesis and develop therapeutic approaches, and (2) a mentoring program to facilitate the career development of new investigators. This award will allow the candidate to have protected time to devote specifically to developing mentoring skills in patient-oriented research in her trainees who are fellows and junior faculty members, and to expand the reach of her mentoring to include new postdoctoral trainees and medical students. Through this award Dr. Young will participate in ongoing educational activities to improve her skills as a mentor, and to develop enhanced clinical research skills focused to genomics and rare diseases. These studies leverage a platform for patient-oriented research in pediatric rare lung diseases and a portfolio of currently funded research projects. In addition, Dr. Young's program in patient-oriented research will be expanded in new and novel directions. Specifically, leveraging existing NHLBI funded research projects, she will focus on identifying genetic mechanisms and modifiable predictors of outcomes in rare childhood interstitial lung diseases. This award will enable Dr. Young to substantially advance the field of pediatric rare lung diseases and enhance her mentoring skills in order to assure strong training for a future generation of patient-oriented researchers.