Midcareer Investigator Award in Patient-Oriented Research in Pediatric Rare Lung Diseases

申请以患者为中心的研究的职业中期研究人员奖的总体目标是 使杨博士能够在以患者为导向的研究中建立和扩展她的研究和指导计划 儿科罕见肺部疾病。罕见的肺部疾病包括一大组与高血压病相关的疾病 儿童发病率，有时甚至死亡。应聘者是Rare临床护理和研究方面的专家 肺部疾病，这个奖项将使她专注于(1)以患者为中心的研究的进一步发展 旨在促进对疾病发病机制的了解和发展的儿科罕见肺部疾病计划 治疗方法，以及(2)一个指导计划，以促进新调查人员的职业发展。 这一奖励将允许候选人有保护的时间专门致力于发展指导技能 在她的受训人员中进行以患者为导向的研究，他们是研究员和初级教员，并扩大 她的指导范围扩大到包括新的博士后实习生和医学生。通过这个奖项，Dr。 杨将参加正在进行的教育活动，以提高她作为导师的技能，并发展 增强了侧重于基因组学和罕见疾病的临床研究技能。这些研究利用了一个平台 用于以患者为中心的儿科罕见肺部疾病研究和目前资助的一系列研究 项目。此外，杨博士的以患者为导向的研究计划将在新的和新颖的方面得到扩展 方向。具体地说，利用现有的NHLBI资助的研究项目，她将专注于确定 少见的儿童间质性肺病的遗传机制和可修改的预后预测因子。这 该奖项将使杨博士能够大幅推进儿科罕见肺部疾病领域，并增强她的 指导技能，以确保对下一代以患者为导向的研究人员进行强有力的培训。

The overall goal of this application for a Midcareer Investigator Award in Patient-Oriented Research is to enable Dr. Young to build and expand her research and mentoring programs in patient-oriented research in Pediatric Rare Lung Diseases. Rare Lung Diseases comprise a large group of disorders associated with high morbidity and sometimes mortality in children. The candidate is an expert in clinical care and research in rare lung diseases, and this award will allow her to focus on further development of (1) a patient-oriented research program in pediatric rare lung diseases aimed to advance understanding of disease pathogenesis and develop therapeutic approaches, and (2) a mentoring program to facilitate the career development of new investigators. This award will allow the candidate to have protected time to devote specifically to developing mentoring skills in patient-oriented research in her trainees who are fellows and junior faculty members, and to expand the reach of her mentoring to include new postdoctoral trainees and medical students. Through this award Dr. Young will participate in ongoing educational activities to improve her skills as a mentor, and to develop enhanced clinical research skills focused to genomics and rare diseases. These studies leverage a platform for patient-oriented research in pediatric rare lung diseases and a portfolio of currently funded research projects. In addition, Dr. Young's program in patient-oriented research will be expanded in new and novel directions. Specifically, leveraging existing NHLBI funded research projects, she will focus on identifying genetic mechanisms and modifiable predictors of outcomes in rare childhood interstitial lung diseases. This award will enable Dr. Young to substantially advance the field of pediatric rare lung diseases and enhance her mentoring skills in order to assure strong training for a future generation of patient-oriented researchers.