Midcareer Investigator Award in Patient-Oriented Research in Pediatric Rare Lung Diseases

儿科罕见肺部疾病以患者为导向的研究中的职业生涯中期研究员奖

• 批准号: 9930249
• 负责人: Lisa R. Young
• 金额: $ 11万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9930249
• 关键词: Address; Adult; American; Award; Biological Markers; Career Mobility; Cessation of life; Chest; Child; Childhood; Chronic Disease; Classification; Clinical; Clinical Practice Guideline; Clinical Research; Development; Diagnostic; Diffuse; Discipline; Disease; Educational Activities; Educational workshop; Enrollment; Faculty; Funding; Future; Future Generations; Genetic; Genetic Predisposition to Disease; Genomics; Goals; Healthcare; Individual; Interstitial Lung Diseases; Lead; Lung diseases; Medical Students; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Natural History; Pathogenesis; Pathology; Pediatric Hospitals; Postdoctoral Fellow; Predictive Factor; Prevalence; Rare Diseases; Recurrence; Registries; Research; Research Personnel; Research Project Grants; Research Training; Resources; Societies; Strategic Planning; System; Therapeutic; Time; Training; Translational Research; United States National Institutes of Health; Work; career; career development; clinical care; cohort; disability; improved; interstitial; member; mortality; new therapeutic target; next generation; novel; outcome prediction; patient oriented; patient oriented research; premature; programs; recruit; skill acquisition; skills; student mentoring; success; training opportunity

The overall goal of this application for a Midcareer Investigator Award in Patient-Oriented Research is to enable Dr. Young to build and expand her research and mentoring programs in patient-oriented research in Pediatric Rare Lung Diseases. Rare Lung Diseases comprise a large group of disorders associated with high morbidity and sometimes mortality in children. The candidate is an expert in clinical care and research in rare lung diseases, and this award will allow her to focus on further development of (1) a patient-oriented research program in pediatric rare lung diseases aimed to advance understanding of disease pathogenesis and develop therapeutic approaches, and (2) a mentoring program to facilitate the career development of new investigators. This award will allow the candidate to have protected time to devote specifically to developing mentoring skills in patient-oriented research in her trainees who are fellows and junior faculty members, and to expand the reach of her mentoring to include new postdoctoral trainees and medical students. Through this award Dr. Young will participate in ongoing educational activities to improve her skills as a mentor, and to develop enhanced clinical research skills focused to genomics and rare diseases. These studies leverage a platform for patient-oriented research in pediatric rare lung diseases and a portfolio of currently funded research projects. In addition, Dr. Young's program in patient-oriented research will be expanded in new and novel directions. Specifically, leveraging existing NHLBI funded research projects, she will focus on identifying genetic mechanisms and modifiable predictors of outcomes in rare childhood interstitial lung diseases. This award will enable Dr. Young to substantially advance the field of pediatric rare lung diseases and enhance her mentoring skills in order to assure strong training for a future generation of patient-oriented researchers.

该申请在以患者为导向的研究中获得中级研究员奖的总体目标是 使Young博士能够在以患者为导向的研究中构建和扩展她的研究和指导计划 小儿罕见的肺部疾病。罕见的肺部疾病包括与高有关的大量疾病 儿童发病，有时死亡。候选人是罕见的临床护理和研究专家 肺部疾病，该奖项将使她能够专注于（1）以患者为导向的研究的进一步发展 小儿罕见肺部疾病计划，旨在提高对疾病发病机理的了解并发展 治疗方法，以及（2）一种指导计划，旨在促进新研究人员的职业发展。 该奖项将使候选人有保护时间专门致力于发展指导技能 在研究人员和初级教职员工的学员中，以患者为导向的研究，并扩大 她的指导范围包括新的博士后学员和医学生。通过这个奖项博士 Young将参加正在进行的教育活动，以提高她作为导师的技能，并发展 增强的临床研究技能专注于基因组学和罕见疾病。这些研究利用平台 用于小儿稀有肺部疾病和目前资助的研究组合的患者研究 项目。此外，Young博士在以患者为导向的研究方面的计划将在新颖的新颖中扩展 方向。具体而言，利用现有的NHLBI资助的研究项目，她将专注于确定 罕见儿童期肺部疾病中遗传机制和可修改结果的预测因子。这 奖项将使Young博士能够实质性地发展儿科罕见的肺部疾病并增强她 指导技能，以确保对未来的以患者为导向的研究人员进行强有力的培训。