Drinking levels (binge, volume) and alcohol consequences: using national data to identify clinical trial endpoints - Administrative Supplement
饮酒水平(酗酒、饮酒量)和酒精后果:使用国家数据确定临床试验终点 - 行政补充
基本信息
- 批准号:10228425
- 负责人:
- 金额:$ 1.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-03-10 至 2022-02-28
- 项目状态:已结题
- 来源:
- 关键词:AcculturationAddressAdministrative SupplementAgeAlcohol abuseAlcohol consumptionAlcohol dependenceAlcoholic IntoxicationAlcoholsAnxiety DisordersAsiansBiologicalBisexualCardiovascular DiseasesCharacteristicsClinical TrialsConsumptionDSM-VDataData AnalysesDetectionDiscriminationDrug Use DisorderElderlyEpidemiologyFamily history ofFemaleGaysGenderGeneral PopulationGeneticGrantHealthHealth PersonnelHealth ProfessionalHeavy DrinkingHeritabilityImpairmentIndividualKnowledgeLesbianLiteratureLiver diseasesMeasuresMinority GroupsOutcomePaperParentsParticipantPatientsPharmaceutical PreparationsPregnancyProviderPublicationsRandomized Clinical TrialsRiskRisk FactorsRunningSiblingsSocioeconomic StatusStressTimeU-Series Cooperative AgreementsUnited States National Institutes of HealthWorkWorld Health OrganizationWritingYouthalcohol consequencesalcohol effectalcohol epidemiologyalcohol responsealcohol riskalcohol use disorderbrief interventioncollegecomorbiditycostdepressive symptomsdesigndrinkingepidemiologic dataexperiencefallshigh riskimprovedmalemembermiddle ageparent grantresponsescreeningscreening and brief interventionsexual minoritysexual relationshipuser-friendlywork-studyyoung adult
项目摘要
PROJECT SUMMARY
In the project, “Drinking Levels (Binge, Volume) And Alcohol Consequences: Using National Data To Identify
Clinical Trial Endpoints” (R01AA025309), epidemiologic data have been used to investigate the relationship of
heavy drinking indicators to the risk for alcohol dependence and other drinking consequences. Much of the work
for this study has focused on whether non-abstinent drinking reductions improve how individuals feel and function
across a broad range of domains. In the project, drinking reduction has primarily been measured by the World
Health Organization (WHO) risk drinking levels: very high risk, high risk, moderate risk, and low risk. These
represent gender-specific average volumes of ethanol consumed per day. Health outcomes have covered a
broad range of domains, including alcohol dependence (occurrence, persistence), impaired functioning, liver
disease, AUDIT-C screening scores, drug use disorders, depressive/anxiety disorders, and cardiovascular
disease. The project has also contributed to papers addressing similar issues regarding WHO risk drinking levels
in treatment data from randomized clinical trials. However, the study did not include the relationship of WHO risk
drinking levels to additional important variables that are often highly related to drinking levels and also to the
outcomes already analyzed. In particular, these additional variables include tolerance to alcohol; family history
of alcohol use disorders; and sexual minority status. In addition, no information exists on whether experiencing
discrimination as a member of a sexual minority group moderates the relationship of sexual minority status to
WHO risk drinking levels. Therefore, Aim 1 of this administrative supplement is to conduct these additional
analyses on WHO risk drinking levels and alcohol tolerance, family history of alcohol use disorders, and sexual
minority status, which will involve unanticipated costs. Furthermore, no document exists that summarizes extant
information on the epidemiology of heavy drinking and alcohol use disorders (AUD), including the findings of the
project, in a user-friendly form for healthcare providers. Healthcare providers are often not knowledgeable about
the epidemiology of heavy drinking and AUD and the benefits of non-abstinent drinking reduction. Providing this
knowledge to them may help them do improved screening and brief interventions with their patients. Therefore,
Aim 2 of this administrative supplement is to prepare a document for healthcare providers that summarizes
accurate knowledge about the epidemiology of heavy drinking and alcohol use disorders in a manner that will
be easy for the healthcare providers to understand and use. This work will also involve unanticipated costs.
项目摘要
在该项目中,“饮酒水平(狂欢,体积)和酒精的后果:使用国家数据来确定
临床试验终点”(R 01 AA 025309),流行病学数据已用于研究
大量饮酒的指标,酒精依赖和其他饮酒后果的风险。大部分工作
因为这项研究的重点是非禁欲饮酒的减少是否会改善个人的感觉和功能
在广泛的领域。在该项目中,饮酒减少主要由世界卫生组织衡量。
世界卫生组织(WHO)的风险饮酒水平:非常高的风险,高风险,中度风险和低风险。这些
代表性别别每天消耗的乙醇平均体积。健康成果涵盖了
广泛的领域,包括酒精依赖(发生,持续),功能受损,肝脏
疾病、AUDIT-C筛查评分、药物使用障碍、抑郁/焦虑障碍和心血管疾病
疾病该项目还为解决有关世卫组织危险饮酒水平的类似问题的论文做出了贡献
随机临床试验的治疗数据。然而,这项研究没有包括世卫组织风险的关系,
饮酒水平与其他重要变量密切相关,这些变量通常与饮酒水平高度相关,
已经分析的结果。特别是,这些额外的变量包括对酒精的耐受性;家族史
酒精使用障碍;和性少数地位。此外,没有信息表明是否经历了
作为性少数群体成员的歧视缓和了性少数地位与
世卫组织饮酒水平的风险。因此,本行政补充的目标1是进行这些额外的
分析WHO风险饮酒水平和酒精耐受性、酒精使用障碍家族史和性行为
少数族裔地位,这将涉及意外费用。此外,没有任何文件总结了现存的
大量饮酒和酒精使用障碍(AUD)的流行病学信息,包括
项目,以用户友好的形式为医疗保健提供者。医疗保健提供者往往不了解
大量饮酒和AUD的流行病学以及非戒酒饮酒减少的益处。提供这种
知识可以帮助他们做更好的筛查和简短的干预与病人。因此,我们认为,
本行政补充文件的目的2是为医疗保健提供者准备一份文件,
准确了解大量饮酒和酒精使用障碍的流行病学,
便于医护人员理解和使用。这项工作还将涉及意料之外的费用。
项目成果
期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Heavy drinking among individuals with HIV: who drinks despite knowledge of the risk?
- DOI:10.1080/09540121.2017.1382676
- 发表时间:2018-05
- 期刊:
- 影响因子:1.7
- 作者:Elliott JC;Stohl M;Hasin DS
- 通讯作者:Hasin DS
Stability of Drinking Reductions and Long-term Functioning Among Patients with Alcohol Use Disorder.
- DOI:10.1007/s11606-020-06331-x
- 发表时间:2021-03
- 期刊:
- 影响因子:5.7
- 作者:Witkiewitz K;Kranzler HR;Hallgren KA;Hasin DS;Aldridge AP;Zarkin GA;Mann KF;O'Malley SS;Anton RF
- 通讯作者:Anton RF
The World Health Organization Risk Drinking Levels Measure of Alcohol Consumption: Prevalence and Health Correlates in Nationally Representative Surveys of U.S. Adults, 2001-2002 and 2012-2013.
- DOI:10.1176/appi.ajp.2020.20050610
- 发表时间:2021-06
- 期刊:
- 影响因子:0
- 作者:Shmulewitz D;Aharonovich E;Witkiewitz K;Anton RF;Kranzler HR;Scodes J;Mann KF;Wall MM;Hasin D;Alcohol Clinical Trials Initiative (ACTIVE Group)
- 通讯作者:Alcohol Clinical Trials Initiative (ACTIVE Group)
The Relationship Between Reductions in WHO Risk Drinking Levels During Treatment and Subsequent Healthcare Costs for the ACTIVE Workgroup.
- DOI:10.1097/adm.0000000000000925
- 发表时间:2022-07-01
- 期刊:
- 影响因子:5.5
- 作者:
- 通讯作者:
World Health Organization risk drinking level reductions are associated with improved functioning and are sustained among patients with mild, moderate and severe alcohol dependence in clinical trials in the United States and United Kingdom.
- DOI:10.1111/add.15011
- 发表时间:2020-09
- 期刊:
- 影响因子:0
- 作者:Witkiewitz K;Heather N;Falk DE;Litten RZ;Hasin DS;Kranzler HR;Mann KF;O'Malley SS;Anton RF
- 通讯作者:Anton RF
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{{ truncateString('DEBORAH S HASIN', 18)}}的其他基金
COVID-19, heavy drinking and alcohol use disorders: a national study of Veterans Administration patients
COVID-19、酗酒和酒精使用障碍:一项针对退伍军人管理局患者的全国研究
- 批准号:
10371482 - 财政年份:2022
- 资助金额:
$ 1.59万 - 项目类别:
COVID-19, heavy drinking and alcohol use disorders: a national study of Veterans Administration patients
COVID-19、酗酒和酒精使用障碍:一项针对退伍军人管理局患者的全国研究
- 批准号:
10596115 - 财政年份:2022
- 资助金额:
$ 1.59万 - 项目类别:
Scientific Conferences for The College on Problems of Drug Dependence (CPDD)
药物依赖问题学院科学会议(CPDD)
- 批准号:
10610865 - 财政年份:2021
- 资助金额:
$ 1.59万 - 项目类别:
Impact of Medical and Recreational Marijuana Laws On Cannabis, Opioids And Psychiatric Medications: National Study of VA Patients, 2000 - 2024
医用和娱乐大麻法对大麻、阿片类药物和精神药物的影响:2000 年至 2024 年退伍军人事务部患者的全国研究
- 批准号:
10393578 - 财政年份:2019
- 资助金额:
$ 1.59万 - 项目类别:
Impact of Medical and Recreational Marijuana Laws On Cannabis, Opioids And Psychiatric Medications: National Study of VA Patients, 2000 - 2024
医用和娱乐大麻法对大麻、阿片类药物和精神药物的影响:2000 年至 2024 年退伍军人事务部患者的全国研究
- 批准号:
10612385 - 财政年份:2019
- 资助金额:
$ 1.59万 - 项目类别:
Drinking levels (binge, volume) and alcohol consequences: using national data to identify clinical trial endpoints
饮酒水平(酗酒、饮酒量)和酒精后果:使用国家数据确定临床试验终点
- 批准号:
9440313 - 财政年份:2016
- 资助金额:
$ 1.59万 - 项目类别:
Drinking levels (binge, volume) and alcohol consequences: using national data to identify clinical trial endpoints
饮酒水平(酗酒、饮酒量)和酒精后果:使用国家数据确定临床试验终点
- 批准号:
9883624 - 财政年份:2016
- 资助金额:
$ 1.59万 - 项目类别:
HealthCall: Enhancing brief intervention for HIV primary care alcohol dependence
HealthCall:加强对艾滋病毒初级保健酒精依赖的短期干预
- 批准号:
9317400 - 财政年份:2014
- 资助金额:
$ 1.59万 - 项目类别:
HealthCall: Enhancing brief intervention for HIV primary care alcohol dependence
HealthCall:加强对艾滋病毒初级保健酒精依赖的短期干预
- 批准号:
8731034 - 财政年份:2014
- 资助金额:
$ 1.59万 - 项目类别:
HealthCall: Enhancing brief intervention for HIV primary care alcohol dependence
HealthCall:加强对艾滋病毒初级保健酒精依赖的短期干预
- 批准号:
8932642 - 财政年份:2014
- 资助金额:
$ 1.59万 - 项目类别:
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