Drinking levels (binge, volume) and alcohol consequences: using national data to identify clinical trial endpoints - Administrative Supplement

项目总结 在该项目中，“饮酒水平(酗酒，饮酒量)和酒精后果：使用国家数据来确定 临床试验终点“(R01AA025309)，流行病学数据已被用来调查与 大量饮酒表明存在酒精依赖和其他饮酒后果的风险。大部分工作 因为这项研究的重点是不节制饮酒是否会改善个人的感觉和功能 跨越了广泛的领域。在该项目中，饮酒的减少主要是由世界银行衡量的 卫生组织(WHO)风险饮酒水平：非常高风险、高风险、中等风险和低风险。这些 表示按性别划分的平均每天乙醇消耗量。健康结果涵盖了 范围广泛，包括酒精依赖(发生、持续)、功能受损、肝脏 疾病、AUDIT-C筛查分数、药物使用障碍、抑郁/焦虑障碍和心血管疾病 疾病。该项目还撰写了关于世卫组织危险饮酒水平的类似问题的论文 来自随机临床试验的治疗数据。然而，这项研究没有包括世卫组织风险的关系 饮酒水平与其他重要变量的关系，这些变量通常与饮酒水平和 结果已经分析过了。特别是，这些额外的变量包括对酒精的耐受性；家族史 酒精使用障碍；性少数群体地位。此外，没有关于是否经历过的信息 作为性少数群体成员的歧视缓和了性少数地位与 他们冒着饮酒过量的风险。因此，本行政副刊的目标1是进行这些额外的 世界卫生组织危险饮酒水平和酒精耐受性、酒精使用障碍家族史和性行为分析 少数族裔身份，这将涉及意想不到的成本。此外，不存在总结现有的文档 关于大量饮酒和酒精使用障碍(AUD)的流行病学信息，包括 项目，以便于医疗保健提供者使用的形式。医疗保健提供者通常不了解 大量饮酒和AUD的流行病学以及非节制饮酒的好处。在此情况下 对他们的了解可能有助于他们对患者进行更好的筛查和简短的干预。因此， 本管理附录的目标2是为医疗保健提供者准备一份文档，该文档总结 准确掌握大量饮酒和酒精使用障碍的流行病学知识 便于医疗保健提供者理解和使用。这项工作还将涉及意想不到的费用。

PROJECT SUMMARY In the project, “Drinking Levels (Binge, Volume) And Alcohol Consequences: Using National Data To Identify Clinical Trial Endpoints” (R01AA025309), epidemiologic data have been used to investigate the relationship of heavy drinking indicators to the risk for alcohol dependence and other drinking consequences. Much of the work for this study has focused on whether non-abstinent drinking reductions improve how individuals feel and function across a broad range of domains. In the project, drinking reduction has primarily been measured by the World Health Organization (WHO) risk drinking levels: very high risk, high risk, moderate risk, and low risk. These represent gender-specific average volumes of ethanol consumed per day. Health outcomes have covered a broad range of domains, including alcohol dependence (occurrence, persistence), impaired functioning, liver disease, AUDIT-C screening scores, drug use disorders, depressive/anxiety disorders, and cardiovascular disease. The project has also contributed to papers addressing similar issues regarding WHO risk drinking levels in treatment data from randomized clinical trials. However, the study did not include the relationship of WHO risk drinking levels to additional important variables that are often highly related to drinking levels and also to the outcomes already analyzed. In particular, these additional variables include tolerance to alcohol; family history of alcohol use disorders; and sexual minority status. In addition, no information exists on whether experiencing discrimination as a member of a sexual minority group moderates the relationship of sexual minority status to WHO risk drinking levels. Therefore, Aim 1 of this administrative supplement is to conduct these additional analyses on WHO risk drinking levels and alcohol tolerance, family history of alcohol use disorders, and sexual minority status, which will involve unanticipated costs. Furthermore, no document exists that summarizes extant information on the epidemiology of heavy drinking and alcohol use disorders (AUD), including the findings of the project, in a user-friendly form for healthcare providers. Healthcare providers are often not knowledgeable about the epidemiology of heavy drinking and AUD and the benefits of non-abstinent drinking reduction. Providing this knowledge to them may help them do improved screening and brief interventions with their patients. Therefore, Aim 2 of this administrative supplement is to prepare a document for healthcare providers that summarizes accurate knowledge about the epidemiology of heavy drinking and alcohol use disorders in a manner that will be easy for the healthcare providers to understand and use. This work will also involve unanticipated costs.