Impact of Medical and Recreational Marijuana Laws On Cannabis, Opioids And Psychiatric Medications: National Study of VA Patients, 2000 - 2024
医用和娱乐大麻法对大麻、阿片类药物和精神药物的影响:2000 年至 2024 年退伍军人事务部患者的全国研究
基本信息
- 批准号:10612385
- 负责人:
- 金额:$ 74.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAgeAlcohol consumptionAlcoholsAnti-Anxiety AgentsAntidepressive AgentsAnxietyAnxiety DisordersAreaAttentionBehaviorCannabisCannabis policyCaringCessation of lifeCharacteristicsComputerized Medical RecordDataData SetDepressive disorderDiagnosisDiseaseDrug PrescriptionsEconomic FactorsEpidemiologyEthnic OriginGeneral PopulationHealthHealth ProfessionalHealthcare SystemsImpairmentIndividualInternal MedicineJusticeKnowledgeLawsLeftLinkLiteratureLow incomeMedicalMedical MarijuanaMedicareMental DepressionMental disordersMethodsModelingModificationNational Institute of Drug AbuseOpioidOutcomeOutcome StudyOverdosePainPatientsPharmaceutical PreparationsPoliciesPolicy MakerPopulationPost-Traumatic Stress DisordersPrevalencePublic HealthRaceRecreationResearchResearch PersonnelResourcesRisk FactorsSymptomsTestingTextTimeTobaccoTobacco useUnited States Department of Veterans AffairsVariantVeterans Health AdministrationVulnerable Populationsaddictionadverse outcomechronic painchronic painful conditionclinical practiceclinical riskdemographicsdesigneffective therapyfederal policyhigh riskhuman old age (65+)hypnoticindexingmalemarijuana usemarijuana use disordermedical examinationmultilevel analysisopioid epidemicopioid policyopioid useopioid use disorderoverdose deathprescription opioidpublic health prioritiessedativesextrend
项目摘要
Thirty states now have medical marijuana laws (MML), 9 have recreational marijuana laws (RML), and many
more states are considering such laws. The health effects of cannabis laws are controversial; understanding
them is a major public health and NIDA priority (PA-17-135). Thus far, only 3 studies of adults (2 of them ours;
Hasin et al., 2017, Martins et al., 2016) used multi-level modeling to examine MML effects on cannabis outcomes
with individual data. These studies suggested post-MML increases in cannabis use and Cannabis Use Disorder
(CUD). However, they left many questions unanswered, including whether MML have stronger effects in those
with key vulnerability factors (chronic pain, psychiatric disorders). In addition, soaring rates of opioid prescriptions
and overdoses have led to calls for MML as part of the solution to the US opioid crisis, but most MML-opioid
studies are ecological (a weak design to study individual behavior), and results from individual-level studies leave
the evidence unclear. Ecological studies also suggest that through cannabis substitution, MML reduce
medication prescriptions for common psychiatric disorders (e.g., PTSD, depression), but no individual-level
studies of this have been conducted. Importantly, RML effects are almost entirely unknown, a major gap in
knowledge. In Veterans Administration (VA) patients, CUD prevalence has doubled since 2002, and in those
age ≥35, is 2-6 times higher than in the general population. VA patients also have high rates of opioid
prescriptions, overdoses, and of chronic pain and psychiatric disorders that may increase their vulnerability to
adverse MML and RML effects. They thus are a large, vulnerable population in whom MML and RML effects are
unknown. We will investigate MML and RML effects utilizing a major resource, the individual data from the VA
Electronic Medical Record, available since 2000 from the ~5,000,000 patients served each year by the VA
healthcare system. We will create yearly EMR datasets, and merge this with National Death Index data, Medicare
data (for those age ≥65) and state-year MML and RML variables that we will create. Using multi-level models
and difference-in-difference tests, we will examine MML and RML effects on three main outcomes: cannabis
(use, CUD), opioids (prescriptions, fatal and non-fatal overdoses, opioid use disorders), and psychotropic
medication prescriptions (antidepressants, anxiolytics, sedatives/hypnotics). Importantly, we will determine if
pain, psychiatric disorders or demographics (sex, age, race/ethnicity) modify MML/RML effects. We will also
examine specific MML/RML provisions, time lags, and breakpoints in trends reflecting federal policy changes.
Analyses will incorporate individual- and state-level confounders, e.g., state norms, economic factors. We will
also explore alcohol and tobacco outcomes. The research team includes substance epidemiology/policy experts
and VA addiction and internal medicine experts. Findings will be disseminated to clinicians and policy-makers.
Determining MML/RML effects in VA patients will make a major contribution to the limited adult literature on
MML/RML, contributing to knowledge that will inform policy and the care of individuals with vulnerability factors.
现在有30个州有医用大麻法(MML), 9个州有娱乐性大麻法(RML),还有很多
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Correction to Lancet Psychiatry 10: 877-86.
《柳叶刀精神病学》10 更正:877-86。
- DOI:10.1016/s2215-0366(23)00362-0
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Prevalence and Correlates of Cannabis Use and Cannabis Use Disorder Among U.S. Veterans: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-III).
- DOI:10.1176/appi.ajp.2021.20081202
- 发表时间:2022-01
- 期刊:
- 影响因子:0
- 作者:Browne KC;Stohl M;Bohnert KM;Saxon AJ;Fink DS;Olfson M;Cerda M;Sherman S;Gradus JL;Martins SS;Hasin DS
- 通讯作者:Hasin DS
Substance, use in relation to COVID-19: A scoping review.
物质,与COVID-19的使用:范围审查。
- DOI:10.1016/j.addbeh.2021.107213
- 发表时间:2022-04
- 期刊:
- 影响因子:4.4
- 作者:Kumar N;Janmohamed K;Nyhan K;Martins SS;Cerda M;Hasin D;Scott J;Sarpong Frimpong A;Pates R;Ghandour LA;Wazaify M;Khoshnood K
- 通讯作者:Khoshnood K
Trends over time in adult cannabis use: A review of recent findings.
- DOI:10.1016/j.copsyc.2021.03.005
- 发表时间:2021-04
- 期刊:
- 影响因子:5.9
- 作者:Hasin D;Walsh C
- 通讯作者:Walsh C
Implications of Medical and Recreational Marijuana Laws for Neuroscience Research: a Review.
- DOI:10.1007/s40473-020-00222-5
- 发表时间:2020-12
- 期刊:
- 影响因子:1.7
- 作者:Hasin DS;Aharonovich E
- 通讯作者:Aharonovich E
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DEBORAH S HASIN其他文献
DEBORAH S HASIN的其他文献
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{{ truncateString('DEBORAH S HASIN', 18)}}的其他基金
COVID-19, heavy drinking and alcohol use disorders: a national study of Veterans Administration patients
COVID-19、酗酒和酒精使用障碍:一项针对退伍军人管理局患者的全国研究
- 批准号:
10371482 - 财政年份:2022
- 资助金额:
$ 74.64万 - 项目类别:
COVID-19, heavy drinking and alcohol use disorders: a national study of Veterans Administration patients
COVID-19、酗酒和酒精使用障碍:一项针对退伍军人管理局患者的全国研究
- 批准号:
10596115 - 财政年份:2022
- 资助金额:
$ 74.64万 - 项目类别:
Scientific Conferences for The College on Problems of Drug Dependence (CPDD)
药物依赖问题学院科学会议(CPDD)
- 批准号:
10610865 - 财政年份:2021
- 资助金额:
$ 74.64万 - 项目类别:
Impact of Medical and Recreational Marijuana Laws On Cannabis, Opioids And Psychiatric Medications: National Study of VA Patients, 2000 - 2024
医用和娱乐大麻法对大麻、阿片类药物和精神药物的影响:2000 年至 2024 年退伍军人事务部患者的全国研究
- 批准号:
10393578 - 财政年份:2019
- 资助金额:
$ 74.64万 - 项目类别:
Drinking levels (binge, volume) and alcohol consequences: using national data to identify clinical trial endpoints - Administrative Supplement
饮酒水平(酗酒、饮酒量)和酒精后果:使用国家数据确定临床试验终点 - 行政补充
- 批准号:
10228425 - 财政年份:2016
- 资助金额:
$ 74.64万 - 项目类别:
Drinking levels (binge, volume) and alcohol consequences: using national data to identify clinical trial endpoints
饮酒水平(酗酒、饮酒量)和酒精后果:使用国家数据确定临床试验终点
- 批准号:
9883624 - 财政年份:2016
- 资助金额:
$ 74.64万 - 项目类别:
Drinking levels (binge, volume) and alcohol consequences: using national data to identify clinical trial endpoints
饮酒水平(酗酒、饮酒量)和酒精后果:使用国家数据确定临床试验终点
- 批准号:
9440313 - 财政年份:2016
- 资助金额:
$ 74.64万 - 项目类别:
HealthCall: Enhancing brief intervention for HIV primary care alcohol dependence
HealthCall:加强对艾滋病毒初级保健酒精依赖的短期干预
- 批准号:
9317400 - 财政年份:2014
- 资助金额:
$ 74.64万 - 项目类别:
HealthCall: Enhancing brief intervention for HIV primary care alcohol dependence
HealthCall:加强对艾滋病毒初级保健酒精依赖的短期干预
- 批准号:
8731034 - 财政年份:2014
- 资助金额:
$ 74.64万 - 项目类别:
HealthCall: Enhancing brief intervention for HIV primary care alcohol dependence
HealthCall:加强对艾滋病毒初级保健酒精依赖的短期干预
- 批准号:
8932642 - 财政年份:2014
- 资助金额:
$ 74.64万 - 项目类别:
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