Interaction of Visual and Oculomotor Signals in Cortex

皮层视觉和动眼神经信号的相互作用

• 批准号: 10227953
• 负责人: TIRIN MOORE
• 金额: $ 37.27万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10227953
• 关键词: Address; Adult; Affect; Area; Attention; Attention deficit hyperactivity disorder; Behavior; Behavioral; Brain; Child; Cognition Disorders; Dopamine; Exhibits; Eye Movements; Funding; Goals; Image; Lead; Maintenance; Mediating; Mental Health; Mental disorders; Methods; Midbrain structure; Motivation; Motor; Movement; Neurons; Parietal; Parietal Lobe; Perception; Prefrontal Cortex; Preparation; Primates; Research; Role; Saccades; Sensory; Short-Term Memory; Signal Transduction; Source; Stimulus; Structure; System; Testing; Time; Vision; Visual; Visual Cortex; Visual Perception; Visual attention; Visual system structure; Work; attentional control; base; behavior influence; combat; contextual factors; density; experimental study; extrastriate; extrastriate visual cortex; frontal eye fields; gaze; innovation; lateral intraparietal area; luminance; mind control; neural circuit; neural correlate; neuromechanism; neurophysiology; nonhuman primate; oculomotor; public health relevance; relating to nervous system; retinal imaging; selective attention; superior colliculus Corpora quadrigemina; tool; virtual; visual cognition; visual information; visual processing; visual stimulus

A fundamental fact of vision is that our perception of the external world is shaped by a number of behavioral and contextual factors. These factors include visual selective attention, in which sensory information is filtered in favor of items that are behaviorally and contextually relevant. In addition, it includes the modulation of visual processing during saccadic eye movements which occur several times each second. These factors are known to modulate the processing of visual information and to contribute to adaptive visually guided behavior. In the primate brain, the visual and oculomotor systems are highly interconnected, and past work has shown that movement-related signals exert robust influences on visual processing in visual cortex. The current proposal focuses on addressing key questions concerning the role of gaze control mechanisms in visual selection and visual stability, two ways in which those mechanisms clearly influence visual perception and cognition. These questions will be addressed using a broad set of innovative approaches and tools including newly developed, large-scale, high-density Neuropixels (NP) probes made specifically for use in nonhuman primates. In this first aim, we will test the role of persistent activity in the selection of visual signals and in visually guided saccades in a set of key, complementary experiments that include large-scale neurophysiological recordings with primate NP probes. Our hypothesis is that persistent activity in the frontal eye field (FEF) serves primarily to select the visual information required to guide saccadic eye movements, and that this function is mediated by dopamine D1Rs. In the second aim, we will address a major open question regarding the basis of stimulus-driven attention by testing the contribution of posterior parietal cortex (PPC) to the representation of visual salience in the brain, and to saliency-driven behavior. Experiments in this aim combine the use of reversible inactivation of PPC with large- scale neurophysiological recordings and behavior. In the third aim, we will address another major open question regarding the basis of the distortions in vision that occur during saccadic eye movements. We will leverage the use of large-scale recordings, and the use of reversible parietal inactivation to test the role of PPC in perisaccadic changes in visual processing within extrastriate visual cortex and the FEF. Overall, our focus on the influence of gaze control mechanisms on visual processing, combined with our use of state-of-the-art neurophysiological approaches and causal methods, are likely to produce results that exert a large and sustained impact on our understanding of the neural mechanisms of visual perception and cognition.

视觉的一个基本事实是，我们对外部世界的感知是由许多 行为和背景因素。这些因素包括视觉选择性注意，其中感觉信息 被过滤，以支持行为和上下文相关的项目。此外，它还包括调制 在每秒发生几次眼跳运动期间的视觉处理能力。这些因素是 已知用于调节视觉信息的处理并有助于自适应视觉引导行为。 在灵长类动物的大脑中，视觉和眼球运动系统高度相连，过去的研究表明 运动相关信号对视觉皮层的视觉加工有很强的影响。目前的提案 重点解决有关凝视控制机制在视觉选择和视觉选择中的作用的关键问题 视觉稳定性，这是这些机制明显影响视觉感知和认知的两种方式。这些 将使用广泛的创新方法和工具来解决问题，包括新开发的、 专门为非人类灵长类动物制造的大规模、高密度神经像素(NP)探头。在这第一次 目的，我们将测试持续活动在视觉信号选择和视觉引导的眼跳中的作用 一组关键的互补性实验，包括对灵长类NP的大规模神经生理记录 探测器。我们的假设是，额叶眼场(FEF)的持续活动主要用于选择视觉 指导眼跳运动所需的信息，这一功能是由多巴胺D1Rs介导的。 在第二个目标中，我们将解决一个关于刺激驱动注意力的基础的重大悬而未决的问题 测试后顶叶皮质(PPC)对大脑中视觉显著表征的贡献，以及 到显著驱动的行为。在这一目标的实验中，结合使用可逆灭活的PPC和大容量的 测量神经生理记录和行为。在第三个目标中，我们将解决另一个重大的未决问题 关于眼跳眼球运动期间视力扭曲的基础。我们将利用 使用大规模记录，并使用可逆性顶叶失活来测试PPC在视交叉中的作用 纹外区视皮层和FEF内视觉加工的变化。总体而言，我们关注的是 视觉处理上的凝视控制机制，结合我们使用的最先进的神经生理学 方法和因果方法，很可能产生对我们的 了解视觉感知和认知的神经机制。