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Interaction of Visual and Oculomotor Signals in Cortex

皮层视觉和动眼神经信号的相互作用

基本信息

批准号：
10667437
负责人：
TIRIN MOORE
金额：
$ 38.37万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-20 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10667437
关键词：
Address Adult Affect Area Attention Attention deficit hyperactivity disorder Behavior Behavioral Brain Child Cognition Disorders Dopamine Exhibits Eye Movements Funding Goals Image Lead Maintenance Mediating Mental Health Mental disorders Methods Midbrain structure Motivation Motor Movement Neurons Parietal Parietal Lobe Perception Prefrontal Cortex Preparation Primates Research Role Saccades Sensory Shapes Short-Term Memory Signal Transduction Source Stimulus Structure System Testing Vision Visual Visual Cortex Visual Perception Visual System Visual attention Work attentional control behavior influence combat contextual factors density experimental study extrastriate extrastriate visual cortex frontal eye fields gaze innovation lateral intraparietal area luminance neural neural circuit neural correlate neuromechanism neurophysiology nonhuman primate oculomotor public health relevance retinal imaging selective attention superior colliculus Corpora quadrigemina tool virtual visual cognition visual control visual information visual processing visual stimulus

项目摘要

A fundamental fact of vision is that our perception of the external world is shaped by a number of behavioral and contextual factors. These factors include visual selective attention, in which sensory information is filtered in favor of items that are behaviorally and contextually relevant. In addition, it includes the modulation of visual processing during saccadic eye movements which occur several times each second. These factors are known to modulate the processing of visual information and to contribute to adaptive visually guided behavior. In the primate brain, the visual and oculomotor systems are highly interconnected, and past work has shown that movement-related signals exert robust influences on visual processing in visual cortex. The current proposal focuses on addressing key questions concerning the role of gaze control mechanisms in visual selection and visual stability, two ways in which those mechanisms clearly influence visual perception and cognition. These questions will be addressed using a broad set of innovative approaches and tools including newly developed, large-scale, high-density Neuropixels (NP) probes made specifically for use in nonhuman primates. In this first aim, we will test the role of persistent activity in the selection of visual signals and in visually guided saccades in a set of key, complementary experiments that include large-scale neurophysiological recordings with primate NP probes. Our hypothesis is that persistent activity in the frontal eye field (FEF) serves primarily to select the visual information required to guide saccadic eye movements, and that this function is mediated by dopamine D1Rs. In the second aim, we will address a major open question regarding the basis of stimulus-driven attention by testing the contribution of posterior parietal cortex (PPC) to the representation of visual salience in the brain, and to saliency-driven behavior. Experiments in this aim combine the use of reversible inactivation of PPC with large- scale neurophysiological recordings and behavior. In the third aim, we will address another major open question regarding the basis of the distortions in vision that occur during saccadic eye movements. We will leverage the use of large-scale recordings, and the use of reversible parietal inactivation to test the role of PPC in perisaccadic changes in visual processing within extrastriate visual cortex and the FEF. Overall, our focus on the influence of gaze control mechanisms on visual processing, combined with our use of state-of-the-art neurophysiological approaches and causal methods, are likely to produce results that exert a large and sustained impact on our understanding of the neural mechanisms of visual perception and cognition.

视觉的一个基本事实是，我们对外部世界的感知是由许多因素决定的。行为和情境因素。这些因素包括视觉选择性注意，其中感官信息被过滤以支持行为和上下文相关的项目。此外，它还包括调制每秒发生数次的眼球扫视运动期间的视觉处理。这些因素是已知可以调节视觉信息的处理并有助于适应性视觉引导行为。在灵长类动物的大脑中，视觉和动眼神经系统高度互连，过去的研究表明运动相关信号对视觉皮层的视觉处理产生强大影响。目前的提案重点解决有关凝视控制机制在视觉选择和视觉选择中的作用的关键问题视觉稳定性，这些机制通过两种方式明显影响视觉感知和认知。这些将使用一系列广泛的创新方法和工具来解决问题，包括新开发的、专门用于非人类灵长类动物的大规模、高密度 Neuropixels (NP) 探针。在这第一目标，我们将测试持续活动在视觉信号选择和视觉引导扫视中的作用一系列关键的、补充性的实验，包括灵长类动物 NP 的大规模神经生理学记录探针。我们的假设是，额叶视野（FEF）的持续活动主要用于选择视觉指导眼球扫视运动所需的信息，并且该功能是由多巴胺 D1R 介导的。在第二个目标中，我们将解决一个关于刺激驱动注意力基础的重大悬而未决的问题测试后顶叶皮层（PPC）对大脑视觉显着性表征的贡献，以及显着性驱动的行为。该目的的实验将 PPC 可逆失活与大衡量神经生理学记录和行为。在第三个目标中，我们将解决另一个重大的悬而未决的问题关于眼球扫视运动期间发生的视觉扭曲的基础。我们将利用使用大规模记录，以及使用可逆的顶叶失活来测试 PPC 在视跳中的作用纹状体视觉皮层和 FEF 内视觉处理的变化。总体而言，我们关注的影响力视觉处理的凝视控制机制，结合我们最先进的神经生理学的使用方法和因果方法，可能会产生对我们产生巨大而持续影响的结果了解视觉感知和认知的神经机制。

项目成果

期刊论文数量（46）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Saccades and shifting receptive fields: anticipating consequences or selecting targets?

DOI：
10.1016/j.tics.2014.10.002
发表时间：
2014-12
期刊：
TRENDS IN COGNITIVE SCIENCES
影响因子：
19.9
作者：
Zirnsak, Marc;Moore, Tirin
通讯作者：
Moore, Tirin

Working memory gates visual input to primate prefrontal neurons.

DOI：
10.7554/elife.64814
发表时间：
2021-06-16
期刊：
eLife
影响因子：
7.7
作者：
Noudoost B;Clark KL;Moore T
通讯作者：
Moore T

Persistent spatial information in the frontal eye field during object-based short-term memory.

DOI：
10.1523/jneurosci.1450-12.2012
发表时间：
2012-08-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Clark KL;Noudoost B;Moore T
通讯作者：
Moore T

Intrinsic timescales in the visual cortex change with selective attention and reflect spatial connectivity.

DOI：
10.1038/s41467-023-37613-7
发表时间：
2023-04-03
期刊：
NATURE COMMUNICATIONS
影响因子：
16.6
作者：
Zeraati, Roxana;Shi, Yan-Liang;Steinmetz, Nicholas A.;Gieselmann, Marc A.;Thiele, Alexander;Moore, Tirin;Levina, Anna;Engel, Tatiana A.
通讯作者：
Engel, Tatiana A.

Exploration Disrupts Choice-Predictive Signals and Alters Dynamics in Prefrontal Cortex.

探索破坏了选择性的信号，并改变了前额叶皮层中的动态。