Conduct of studies to evaluate the subchronic and developmental neurotoxicity of isopropylated phenol phosphate in rats (after perinatal exposure) for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估异丙基苯酚磷酸盐对大鼠（围产期暴露后）的亚慢性和发育神经毒性

• 批准号: 10274358
• 负责人: MILTON HEJTMANCIK
• 金额: $ 55.03万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2021-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10274358
• 关键词: Adverse effects; Chemicals; Data; Development; Dose; Ensure; Environment; Environmental Exposure; Evaluation; Exposure to; Fiber; Flame Retardants; General Population; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Lactation; Metals; Mus; National Toxicology Program; Perinatal Exposure; Phenols; Pregnancy; Rattus; Risk Assessment; Risk Factors; Toxic effect; Toxicity Tests; Toxicology; Tungsten; Weaning; consumer product; design; developmental neurotoxicity; developmental toxicity; disorder prevention; inorganic phosphate; public health research; sound

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of tungsten metal and isopropylated phenol phosphate in rats, following exposure via dosed feed; exposures occur during gestation and lactation and for three months after weaning. Isopropylated phenol phosphate is an aromatic organo phosphate flame retardant. Increased use is anticipated as this class is replacing other classes of flame retardants. Exposure to isopropylated phenol phosphate occurs in the general population via its presence in consumer products and in the environment. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of tungsten metal and suboxide fibers in rats and mice and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to different forms of tungsten. Keywords: toxicity, isopropylated phenol phosphate, dosed feed, flame retardant

该项目的目标是为国家毒理学计划(NTP)的危险识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。需要适当地进行毒理学研究，以确保结果数据是可靠的。该项目涉及通过剂量饲料接触金属钨和异丙基苯酚磷酸盐对大鼠的毒性研究；暴露发生在怀孕和哺乳期间以及断奶后三个月。异丙基苯酚磷酸酯是一种芳香族有机磷酸盐类阻燃剂。随着这类阻燃剂取代其他类别的阻燃剂，预计会有更多的使用。通过在消费品和环境中存在异丙基苯酚磷酸盐，在普通人群中会发生接触异丙基苯酚磷酸盐的情况。该项目的数据将用于就钨金属和次氧化物纤维对大鼠和小鼠的潜在毒性得出合理的科学结论，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，公众可充分了解因接触不同形式的钨而产生的危险因素。 关键词：毒性、异丙基苯酚磷酸酯、配料、阻燃剂