Conduct of studies to evaluate the subchronic and developmental neurotoxicity of isopropylated phenol phosphate in rats (after perinatal exposure) for the National Toxicology Program (NTP)

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The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of tungsten metal and isopropylated phenol phosphate in rats, following exposure via dosed feed; exposures occur during gestation and lactation and for three months after weaning. Isopropylated phenol phosphate is an aromatic organo phosphate flame retardant. Increased use is anticipated as this class is replacing other classes of flame retardants. Exposure to isopropylated phenol phosphate occurs in the general population via its presence in consumer products and in the environment. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of tungsten metal and suboxide fibers in rats and mice and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to different forms of tungsten. Keywords: toxicity, isopropylated phenol phosphate, dosed feed, flame retardant