课题基金 / 基金详情

Support of the Research Effort to Evaluate the Cardiotoxic Potential of Multiple Test Agents in Rats

Support of the Research Effort to Evaluate the Cardiotoxic Potential of Multiple Test Agents in Rats
支持评估多种测试药物对大鼠的心脏毒性潜力的研究工作
批准号：
10710449
负责人：
MILTON HEJTMANCIK
金额：
$23.33万
依托单位：
BATTELLE MEMORIAL INSTITU
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-04-15 至 2023-04-14
来源：
https://reporter.nih.gov/project-details/10710449
关键词：
CardiotoxicityChemicalsDataDoseEvaluationHeartHistopathologyHumanIn VitroLiteratureMonitorOralPublishingRattusResearch SupportTestingToxic effectToxicologyTranslationsanimal databasedesignin vitro testingin vivotranscriptomics

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英文摘要
This project conducted for the Division of Translational Toxicology (DTT) is designed to develop and qualify a toxicity evaluation pipeline for test agents with cardiotoxic potential. A suite of 9-10 chemicals were selected based on demonstrating the ability to be cardiotoxic from published literature of mechanistic, in vitro or in vivo studies. These chemicals are being tested in a 14-day repeat oral gavage study in rats with an emphasis on evaluation of the heart using histopathology and transcriptomics, as well as internal dose monitoring to provide translational data for animal to human and in vitro to in vivo extrapolation.
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Support of the Research Effort to Evaluate the Cardiotoxic Potential of Multiple Test Agents in Rats
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