Inflammation and Therapy for Respiratory Virus Infection
Inflammation and Therapy for Respiratory Virus Infection
批准号:
10272105
负责人:
HELENE ROSENBERG
金额:
$47.31万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
AcuteAcute respiratory infectionAnimal ModelAntihypertensive AgentsAntiviral AgentsBlood VesselsCandidate Disease GeneCapillary Leak SyndromeCessation of lifeCharacteristicsChromosome 6ClinicalDevelopmentDiseaseEdemaEtiologyExtravasationFamilyGeneticGenetic DeterminismHistamineHumanHypersensitivityInbred MouseInbred Strains MiceInfantInfectionInflammationInflammatoryInflammatory ResponseInfluenza A virusInterruptionKnowledgeLactobacillusLactobacillus plantarumLigandsLiquid substanceManuscriptsMapsMediatingModelingMolecularMurine pneumonia virusMusNamesPathologicPathologyPattern recognition receptorPeripheralPlayPredispositionProteinsReagentRecurrenceReportingResearchRespiratory FailureRespiratory MucosaRespiratory Syncytial Virus InfectionsRespiratory SystemRespiratory TherapyRobin birdRoleSeriesShockSignal TransductionSourceSyndromeTherapeuticTissuesVirusVirus ReplicationWild Type MouseWorkWritingcytokinegenetic analysisgenomic locusin vivointerestmouse modelpathogenrespiratoryrespiratory infection virusresponsetraittreatment strategy
中文摘要
正在进行的研究重点是探索急性呼吸道病毒感染的病理性炎症反应,并利用这些信息制定创造性策略,以规避这种疾病的致命后遗症特征。
英文摘要
Ongoing research focuses on the exploration of pathologic inflammatory responses to acute respiratory virus infection and the use of this information to develop creative strategies to circumvent the lethal sequelae characteristic of this disease.
In Fiscal year (FY) 2020, we contributed to one (1) original research manuscript:
Manuscript #1:
Title: A natural mouse model reveals genetic determinants of systemic capillary leak syndrome
(Clarkson disease).
The systemic capillary leak syndrome (SCLS, Clarkson disease) is a disorder of unknown etiology characterized by recurrent episodes of vascular leakage of proteins and fluids into peripheral tissues, resulting in whole-body edema and hypotensive shock. The pathologic mechanisms and genetic basis for SCLS remain elusive. Here we identify an inbred mouse strain, SJL, which recapitulates cardinal features of SCLS, including susceptibility to histamine- and infection-triggered vascular leak. We named this trait "Histamine hypersensitivity" (Hhs/Hhs) and mapped it to Chromosome 6. Hhs is syntenic to the genomic locus most strongly associated with SCLS in humans (3p25.3), revealing that the predisposition to develop vascular hyperpermeability has a strong genetic component conserved between humans and mice and providing a naturally occurring animal model for SCLS. Genetic analysis of Hhs may reveal orthologous candidate genes that contribute not only to SCLS, but also to normal and dysregulated mechanisms underlying vascular barrier function more generally.
Our contribution: We provided expertise and reagents that facilitated an exploration of the responses of these mice to an acute respiratory virus infection, one of the major pathophysiologic factors that incite vascular leak in this syndrome.
Ref: Raza A, Xie Z, Chan EC, Chen WS, Scott LM, Robin Eisch A, Krementsov DN, Rosenberg HF, Parikh SM, Blankenhorn EP, Teuscher C, Druey KM. 2019. Commun Biol. 2:398.
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DOI:
10.1016/j.imlet.2016.02.012
发表时间:
2016-04
期刊:
Immunology letters
影响因子:
4.4
作者:
[Brenner TA, Rice TA, Anderson ED, Percopo CM, Rosenberg HF]
通讯作者:
Rosenberg HF
DOI:
10.1177/0009922810394834
发表时间:
2011-06
期刊:
Clinical pediatrics
影响因子:
1.6
作者:
[Suryadevara M, Cummings E, Bonville CA, Bartholoma N, Riddell S, Kiska D, Rosenberg HF, Domachowske JB]
通讯作者:
Domachowske JB
DOI:
10.4049/jimmunol.1002635
发表时间:
2011-05-15
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
[Davidson S, Kaiko G, Loh Z, Lalwani A, Zhang V, Spann K, Foo SY, Hansbro N, Uematsu S, Akira S, Matthaei KI, Rosenberg HF, Foster PS, Phipps S]
通讯作者:
Phipps S
Local production of CCL3, CCL11, and IFN-γ correlates with disease severity in murine parainfluenza virus infection.
CCL3、CCL11 和 IFN-γ 的本地产生与鼠副流感病毒感染的疾病严重程度相关。
DOI:
10.1186/1743-422x-10-357
发表时间:
2013
期刊:
Virology journal
影响因子:
4.8
作者:
[Suryadevara,Manika, Bonville,CynthiaA, Rosenberg,HeleneF, Domachowske,JosephB]
通讯作者:
Domachowske,JosephB
Inflammatory responses to respiratory syncytial virus (RSV) infection and the development of immunomodulatory pharmacotherapeutics.
呼吸道合胞病毒(RSV)感染的炎症反应和免疫调节药物治疗的发展。
DOI:
10.2174/092986712799828346
发表时间:
2012
期刊:
Current medicinal chemistry
影响因子:
4.1
作者:
[Rosenberg HF, Domachowske JB]
通讯作者:
Domachowske JB
共 13 条
CARDIOTOXICITY OF EOSINOPHIL GRANULE CATIONIC PROTEINS
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批准号:3087626
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项目类别:
-
资助金额:$6.89万
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财政年份:1989
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负责人:HELENE ROSENBERG
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依托单位:
CARDIOTOXICITY OF EOSINOPHIL GRANULE CATIONIC PROTEINS
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批准号:3087628
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项目类别:
-
资助金额:$8.39万
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财政年份:1989
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负责人:HELENE ROSENBERG
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依托单位:
CARDIOTOXICITY OF EOSINOPHIL GRANULE CATIONIC PROTEINS
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批准号:3087627
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项目类别:
-
资助金额:$6.93万
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财政年份:1989
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负责人:HELENE ROSENBERG
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依托单位:
HUMAN PHAGOCYTE GRANULE PROTEINS
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批准号:6431620
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Inflammation and Therapy for Respiratory Virus Infection
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批准号:7006273
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Molecular Biology of the Ribonuclease A Gene Superfamily
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批准号:7964509
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项目类别:
-
资助金额:$42.3万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Inflammation and Therapy for Respiratory Virus Infection
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批准号:8745415
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项目类别:
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资助金额:$68.15万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Molecular Biology of the Ribonuclease A Gene Superfamily
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批准号:7732597
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项目类别:
-
资助金额:$68.17万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Molecular Biology of the Ribonuclease A Gene Superfamily
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批准号:7196724
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Biology of the Eosinophilic Leukocyte
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批准号:7592297
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项目类别:
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资助金额:$83.55万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Eosinophils, Inflammation and Immunity
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批准号:9566631
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项目类别:
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资助金额:$65.59万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Biology of the Eosinophilic Leukocyte
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批准号:7964507
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项目类别:
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资助金额:$117.34万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Inflammation and Therapy for Respiratory Virus Infection
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批准号:8946378
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项目类别:
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资助金额:$61.75万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Inflammation and Therapy for Respiratory Virus Infection
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批准号:7732598
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项目类别:
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资助金额:$73.65万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Molecular Biology of the Ribonuclease A Gene Superfamily
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批准号:8156960
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项目类别:
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资助金额:$19.07万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Biology of the Eosinophilic Leukocyte
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批准号:8156959
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项目类别:
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资助金额:$109.56万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Eosinophils, Inflammation and Immunity
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批准号:10272104
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项目类别:
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资助金额:$47.31万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
HUMAN PHAGOCYTE GRANULE PROTEINS
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批准号:6099004
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
HUMAN PHAGOCYTE GRANULE PROTEINS
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批准号:6288908
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
Biology of the Eosinophilic Leukocyte
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批准号:6987123
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:HELENE ROSENBERG
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依托单位:
海外基金