Nonlinear Models of Cognition Preceding AD in a Biracial Population Sample

混血人群样本中 AD 之前认知的非线性模型

• 批准号: 10319798
• 负责人: Kumar B. Rajan
• 金额: $ 35.15万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-25 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10319798
• 关键词: Nonlinear; Models; Cognition; Preceding; AD

This proposal aims to conduct secondary analyses of existing data to examine nonlinear cognitive decline in standardized global summary of cognition assessed using executive functioning, episodic memory, and overall global cognition and orientation within the context of a large population-based study of older adults: Chicago Health and Aging Project (CHAP). More specifically, the four objectives of this proposal are: 1) Examine Nonlinear Cognitive Decline in Older Blacks and Whites Using Change Point Models in a Random Sample of 2,948 Participants with AD and non-AD Diagnosis; 2) investigate the Role of Demographic, Social, Lifestyle, Cardiovascular, and Genetic Risk Factors on Nonlinear Cognitive Decline in Older Blacks and Whites with AD and non-AD Diagnosis; 3) Identify the Heterogeneity in Nonlinear Cognitive Decline Using Latent Class Growth Curve Models Using a Population Sample of 7,757 Blacks and Whites with Multiple Cognitive Assessments; 4) Understand the Role of Demographic, Social, Lifestyle, Cardiovascular, and Genetic Risk Factors on Latent Class Memberships to Explain Heterogeneity in Nonlinear Cognitive Decline. Understanding the rate of cognitive decline in older blacks and whites has a topic of considerable interest. However, most research has focused on linear trajectories in whites with mixed findings among blacks. Nonlinear cognitive decline based on change points are nonexistent in blacks and the proposed work can increase our understanding of preclinical phase of AD and non-AD.

该提案旨在对现有数据进行二次分析，以检查非线性认知衰退 使用执行功能、情景记忆和评估的标准化全球认知总结 在一项针对老年人的大型人口研究背景下的总体全球认知和取向： 芝加哥健康与老龄化项目（CHAP）。更具体地说，该提案的四个目标是：1) 使用随机变化点模型检查老年黑人和白人的非线性认知衰退 2,948 名患有 AD 和非 AD 诊断的参与者的样本； 2）调查人口统计的作用， 老年黑人非线性认知衰退的社会、生活方式、心血管和遗传风险因素 患有 AD 和非 AD 诊断的白人； 3）识别非线性认知衰退的异质性 使用潜在阶级增长曲线模型，使用 7,757 名黑人和白人的人口样本 多重认知评估； 4) 了解人口、社会、生活方式、心血管、 潜在类别成员资格和遗传风险因素解释非线性认知的异质性 衰退。了解老年黑人和白人认知能力下降的速度是一个相当重要的话题 兴趣。然而，大多数研究都集中在白人的线性轨迹上，其中的结果不一。 黑人。基于变化点的非线性认知衰退在黑人中不存在，并且提出的 工作可以增加我们对 AD 和非 AD 临床前阶段的了解。

项目成果

Lifestyle and Cognitive Decline in Community-Dwelling Stroke Survivors.

• DOI: 10.3233/jad-220305
• 发表时间: 2022
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Dhana, Klodian;Aggarwal, Neelum T.;Beck, Todd;Holland, Thomas M.;Dhana, Anisa;Cherian, Laurel J.;Desai, Pankaja;Evans, Denis A.;Rajan, Kumar B.
• 通讯作者: Rajan, Kumar B.

Remote Blood Biomarkers of Longitudinal Cognitive Outcomes in a Population Study.

• DOI: 10.1002/ana.25874
• 发表时间: 2020-12
• 期刊: ANNALS OF NEUROLOGY
• 影响因子: 11.2
• 作者: Rajan, Kumar B.;Aggarwal, Neelum T.;McAninch, Elizabeth A.;Weuve, Jennifer;Barnes, Lisa L.;Wilson, Robert S.;DeCarli, Charles;Evans, Denis A.
• 通讯作者: Evans, Denis A.

Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060).

• DOI: 10.1002/alz.12362
• 发表时间: 2021-12
• 期刊: ALZHEIMERS & DEMENTIA
• 影响因子: 14
• 作者: Rajan, Kumar B.;Weuve, Jennifer;Barnes, Lisa L.;McAninch, Elizabeth A.;Wilson, Robert S.;Evans, Denis A.
• 通讯作者: Evans, Denis A.

Cognitive Activity Is Associated with Cognitive Function over Time in a Diverse Group of Older Adults, Independent of Baseline Biomarkers.

在不同的老年人群体中，随着时间的推移，认知活动与认知功能相关，与基线生物标志物无关。

• DOI: 10.1159/000531208
• 发表时间: 2023
• 期刊: Neuroepidemiology
• 影响因子: 5.7
• 作者: Krueger,KristinR;Desai,Pankaja;Beck,Todd;Wilson,RobertS;Evans,Denis;Rajan,KumarB
• 通讯作者: Rajan,KumarB

Temporal changes in the likelihood of dementia and MCI over 18 years in a population sample.

人口样本中 18 年来痴呆和 MCI 可能性的时间变化。

• DOI: 10.1212/wnl.0000000000008731
• 发表时间: 2020
• 期刊: Neurology
• 影响因子: 9.9
• 作者: Rajan,KumarB;Weuve,Jennifer;Wilson,RobertS;Barnes,LisaL;McAninch,ElizabethA;Evans,DenisA
• 通讯作者: Evans,DenisA