Nonlinear Models of Cognition Preceding AD in a Biracial Population Sample
Nonlinear Models of Cognition Preceding AD in a Biracial Population Sample
批准号:
10319798
负责人:
Kumar B. Rajan
金额:
$35.15万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-05-25 至 2022-05-31
中文摘要
本提案旨在对现有数据进行二次分析,以检验非线性认知衰退
英文摘要
This proposal aims to conduct secondary analyses of existing data to examine nonlinear cognitive decline
in standardized global summary of cognition assessed using executive functioning, episodic memory, and
overall global cognition and orientation within the context of a large population-based study of older adults:
Chicago Health and Aging Project (CHAP). More specifically, the four objectives of this proposal are: 1)
Examine Nonlinear Cognitive Decline in Older Blacks and Whites Using Change Point Models in a Random
Sample of 2,948 Participants with AD and non-AD Diagnosis; 2) investigate the Role of Demographic,
Social, Lifestyle, Cardiovascular, and Genetic Risk Factors on Nonlinear Cognitive Decline in Older Blacks
and Whites with AD and non-AD Diagnosis; 3) Identify the Heterogeneity in Nonlinear Cognitive Decline
Using Latent Class Growth Curve Models Using a Population Sample of 7,757 Blacks and Whites with
Multiple Cognitive Assessments; 4) Understand the Role of Demographic, Social, Lifestyle, Cardiovascular,
and Genetic Risk Factors on Latent Class Memberships to Explain Heterogeneity in Nonlinear Cognitive
Decline. Understanding the rate of cognitive decline in older blacks and whites has a topic of considerable
interest. However, most research has focused on linear trajectories in whites with mixed findings among
blacks. Nonlinear cognitive decline based on change points are nonexistent in blacks and the proposed
work can increase our understanding of preclinical phase of AD and non-AD.
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DOI:
10.3233/jad-220305
发表时间:
2022
期刊:
JOURNAL OF ALZHEIMERS DISEASE
影响因子:
4
作者:
[Dhana, Klodian, Aggarwal, Neelum T., Beck, Todd, Holland, Thomas M., Dhana, Anisa, Cherian, Laurel J., Desai, Pankaja, Evans, Denis A., Rajan, Kumar B.]
通讯作者:
Rajan, Kumar B.
DOI:
10.1002/ana.25874
发表时间:
2020-12
期刊:
ANNALS OF NEUROLOGY
影响因子:
11.2
作者:
[Rajan, Kumar B., Aggarwal, Neelum T., McAninch, Elizabeth A., Weuve, Jennifer, Barnes, Lisa L., Wilson, Robert S., DeCarli, Charles, Evans, Denis A.]
通讯作者:
Evans, Denis A.
DOI:
10.1002/alz.12362
发表时间:
2021-12
期刊:
ALZHEIMERS & DEMENTIA
影响因子:
14
作者:
[Rajan, Kumar B., Weuve, Jennifer, Barnes, Lisa L., McAninch, Elizabeth A., Wilson, Robert S., Evans, Denis A.]
通讯作者:
Evans, Denis A.
Cognitive Activity Is Associated with Cognitive Function over Time in a Diverse Group of Older Adults, Independent of Baseline Biomarkers.
在不同的老年人群体中,随着时间的推移,认知活动与认知功能相关,与基线生物标志物无关。
DOI:
10.1159/000531208
发表时间:
2023
期刊:
Neuroepidemiology
影响因子:
5.7
作者:
[Krueger,KristinR, Desai,Pankaja, Beck,Todd, Wilson,RobertS, Evans,Denis, Rajan,KumarB]
通讯作者:
Rajan,KumarB
Temporal changes in the likelihood of dementia and MCI over 18 years in a population sample.
人口样本中 18 年来痴呆和 MCI 可能性的时间变化。
DOI:
10.1212/wnl.0000000000008731
发表时间:
2020
期刊:
Neurology
影响因子:
9.9
作者:
[Rajan,KumarB, Weuve,Jennifer, Wilson,RobertS, Barnes,LisaL, McAninch,ElizabethA, Evans,DenisA]
通讯作者:
Evans,DenisA
共 10 条
Data Management and Statistical Core
-
批准号:10666437
-
项目类别:
-
资助金额:$33.29万
-
财政年份:2021
-
负责人:Kumar B. Rajan
-
依托单位:
Data Management and Statistical Core
-
批准号:10461123
-
项目类别:
-
资助金额:$33.19万
-
财政年份:2021
-
负责人:Kumar B. Rajan
-
依托单位:
Statistics Core
-
批准号:10266151
-
项目类别:
-
资助金额:$72.36万
-
财政年份:2020
-
负责人:Kumar B. Rajan
-
依托单位:
Statistics Core
-
批准号:10489295
-
项目类别:
-
资助金额:$119.54万
-
财政年份:2020
-
负责人:Kumar B. Rajan
-
依托单位:
Factors Influencing Decline in AD Trends in a Biracial Population Study
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批准号:9745784
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项目类别:
-
资助金额:$51.58万
-
财政年份:2017
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负责人:Kumar B. Rajan
-
依托单位:
Factors Influencing Decline in AD Trends in a Biracial Population Study
-
批准号:9422107
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项目类别:
-
资助金额:$9.28万
-
财政年份:2017
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负责人:Kumar B. Rajan
-
依托单位:
Nonlinear Models of Cognition Preceding AD and non-AD in a Biracial Population Sample
-
批准号:9174766
-
项目类别:
-
资助金额:$27.13万
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财政年份:2016
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负责人:Kumar B. Rajan
-
依托单位:
Nonlinear Models of Cognition Preceding AD and non-AD in a Biracial Population Sample
-
批准号:9339530
-
项目类别:
-
资助金额:$27.13万
-
财政年份:2016
-
负责人:Kumar B. Rajan
-
依托单位:
Core C: Data Management and Statistical Core
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批准号:9978578
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项目类别:
-
资助金额:$22.97万
-
财政年份:--
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负责人:Kumar B. Rajan
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依托单位:
Core C: Data Management and Statistical Core
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批准号:9754733
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项目类别:
-
资助金额:$20.25万
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财政年份:--
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负责人:Kumar B. Rajan
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依托单位:
国内基金
海外基金
Scalable Learning and Optimization: High-dimensional Models and Online Decision-Making Strategies for Big Data Analysis
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批准号:--
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项目类别:合作创新研究团队
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资助金额:--
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批准年份:2024
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负责人:姚韬
-
依托单位:
新型手性NAD(P)H Models合成及生化模拟
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批准号:20472090
-
项目类别:面上项目
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资助金额:23.0万元
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批准年份:2004
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负责人:王乃兴
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依托单位: