Nonlinear Models of Cognition Preceding AD in a Biracial Population Sample

这项提案旨在对现有数据进行二次分析，以检查非线性认知能力下降 在使用执行功能、情景记忆和 在一项以老年人为基础的大规模人群研究背景下的总体认知和定向： 芝加哥健康与老龄化项目。具体而言，本建议的四个目标是： 使用随机变点模型检查老年黑人和白人的非线性认知下降 2，948名AD和非AD诊断参与者的样本; 2）调查人口统计学的作用， 社会、生活方式、心血管和遗传危险因素对老年黑人非线性认知能力下降的影响 和白人AD和非AD诊断; 3）识别非线性认知衰退中的异质性 使用潜在类别增长曲线模型，使用7，757名黑人和白人的人口样本， 多项认知评估; 4）了解人口统计学，社会，生活方式，心血管， 和遗传危险因素对潜在类别差异的影响，以解释非线性认知中的异质性 下降了解老年黑人和白人的认知能力下降率是一个相当重要的话题。 兴趣然而，大多数研究都集中在白人的线性轨迹上， 黑人基于变化点的非线性认知下降在黑人中是不存在的， 工作可以增加我们对AD和非AD的临床前阶段的理解。

This proposal aims to conduct secondary analyses of existing data to examine nonlinear cognitive decline in standardized global summary of cognition assessed using executive functioning, episodic memory, and overall global cognition and orientation within the context of a large population-based study of older adults: Chicago Health and Aging Project (CHAP). More specifically, the four objectives of this proposal are: 1) Examine Nonlinear Cognitive Decline in Older Blacks and Whites Using Change Point Models in a Random Sample of 2,948 Participants with AD and non-AD Diagnosis; 2) investigate the Role of Demographic, Social, Lifestyle, Cardiovascular, and Genetic Risk Factors on Nonlinear Cognitive Decline in Older Blacks and Whites with AD and non-AD Diagnosis; 3) Identify the Heterogeneity in Nonlinear Cognitive Decline Using Latent Class Growth Curve Models Using a Population Sample of 7,757 Blacks and Whites with Multiple Cognitive Assessments; 4) Understand the Role of Demographic, Social, Lifestyle, Cardiovascular, and Genetic Risk Factors on Latent Class Memberships to Explain Heterogeneity in Nonlinear Cognitive Decline. Understanding the rate of cognitive decline in older blacks and whites has a topic of considerable interest. However, most research has focused on linear trajectories in whites with mixed findings among blacks. Nonlinear cognitive decline based on change points are nonexistent in blacks and the proposed work can increase our understanding of preclinical phase of AD and non-AD.