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Building a Statistics Education Program for Preclinical Cancer Researchers

为临床前癌症研究人员建立统计教育计划

基本信息

批准号：
10334860
负责人：
Sujata Patil
金额：
$ 8.61万
依托单位：
CLEVELAND CLINIC LERNER COM-CWRU
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10334860
关键词：
Building Statistics Education Program Preclinical

项目摘要

ABSTRACT In the past decade, the cancer research community has made considerable progress in characterizing the genomic features of human tumors. Knowledge of molecular drivers of cancer has therefore increased greatly. Although the oncology community hoped that this would lead to more effective therapies, our ability to translate laboratory cancer research into clinical success has been remarkably low – only 5% of the agents demonstrated to have anticancer activity in laboratory studies went on to achieve success in phase III clinical trials. Many factors are responsible for this disturbingly high percentage of failures, including misuse or misunderstanding of statistical design and analysis concepts, interpretation and reporting methods. Although correctable, these issues are widely prevalent in the cancer biomedical research enterprise. Another concern is that statistics training is not a required component of graduate programs in biomedical sciences. Recognizing the seriousness of these issues, the National Institutes of Health has called for the full engagement of the entire biomedical research enterprise to implement the resources needed to improve and sustain the statistical rigor and successful translation of preclinical cancer research. To this end, we propose to develop a statistics curriculum for early-career preclinical cancer researchers (i.e., postdoctoral researchers) conducting laboratory research at Memorial Sloan Kettering Cancer Center as well as the broader research community. Our proposed curriculum will be delivered over a 10-week period with one 90-minute class per week in a flipped classroom format, where lecture notes will be disseminated one week prior to each classroom contact and classroom time will be dedicated to hands-on activities with experimental designs, data analysis and participatory dialogues. We will develop a plan for evaluating our proposed curriculum and make all the resources available to the broader statistics and cancer research communities.

抽象的在过去的十年中，癌症研究界在描述癌症特征方面取得了相当大的进展。人类肿瘤的基因组特征。因此，对癌症分子驱动因素的了解大大增加。尽管肿瘤学界希望这将带来更有效的治疗方法，但我们的翻译能力实验室癌症研究转化为临床成功的比例非常低——只有 5% 的药物实验室研究证明具有抗癌活性，并在 III 期临床中取得成功试验。许多因素造成了如此高的故障比例，包括误用或对统计设计和分析概念、解释和报告方法的误解。虽然这些问题是可以纠正的，在癌症生物医学研究企业中广泛存在。另一个问题是统计培训不是生物医学研究生课程的必需组成部分。认识鉴于这些问题的严重性，美国国立卫生研究院呼吁各部门充分参与整个生物医学研究企业实施改善和维持统计所需的资源临床前癌症研究的严谨和成功转化。为此，我们建议制定一个统计早期职业临床前癌症研究人员（即博士后研究人员）进行实验室的课程纪念斯隆凯特琳癌症中心以及更广泛的研究界的研究。我们的拟议的课程将在 10 周内提供，每周一节 90 分钟的翻转课程课堂形式，讲稿将在每次课堂接触前一周分发，课堂时间将致力于实验设计、数据分析和实践活动参与式对话。我们将制定一个计划来评估我们提议的课程，并制定所有计划提供给更广泛的统计和癌症研究界的资源。