Respiratory effects of e-cigarette use among youth: a prospective, longitudinal investigation

项目摘要 电子烟(EC)仍然是高中生最常用的产品。鲜为人知 关于ECS的急性和纵向呼吸效应。这项新颖的研究将有助于提供批判性知识 需要了解150名独家EC青年的肺功能和呼吸影响 (n=100)或从不吸食(N=50；EC或其他烟草制品)，采用纵向、多方法设计。 青少年将完成5个实验室的评估，以提供对呼吸健康的全面评估 (呼吸道反应性和炎症；肺功能)。此外，我们将把EC用户地形图纳入 评估EC使用对呼吸标志物的即刻急性影响。化验前两周 青少年将完成每天的EMA和肺活量测定评估，以检查频率和 EC使用量会损害急性肺功能。这一烟草监管机构K01将提供更多 需要关于使用EC的直接和纵向影响的证据，同时提供有价值的培训 一位来自烟草监管科学领域顶尖专家的有前途的新研究员。

PROJECT ABSTRACT Electronic cigarettes (EC) remain the most commonly used product among high schoolers. Little is known about acute and longitudinal respiratory effects of ECs. This novel study will contribute critical knowledge needed to understand pulmonary functioning and respiratory effects among 150 youth who are exclusive-EC (N = 100) or never-users (N = 50; EC or other tobacco products), using a longitudinal, multimethod design. Youth will complete 5-laboratory assessments to provide a comprehensive assessment of respiratory health (airway reactivity and inflammation; pulmonary functioning). Further, we will incorporate EC user topography to assess the immediate acute effects of EC use on respiratory markers. Two weeks prior to laboratory assessments youth will complete daily EMA and spirometry assessments to examine how the frequency and quantity of EC use impairs acute pulmonary functioning. This Tobacco Regulatory K01 will provide much needed evidence regarding the immediate and longitudinal effects of EC use, while providing valuable training to a promising new investigator from leading experts in the field of tobacco regulatory science.