Respiratory effects of e-cigarette use among youth: a prospective, longitudinal investigation

青少年使用电子烟对呼吸系统的影响：前瞻性纵向调查

• 批准号: 10461046
• 负责人: Alayna Pauline Tackett
• 金额: $ 19.66万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-17 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10461046
• 关键词: Acute; Address; Adolescence; Adolescent; Adult; Age; Airway Resistance; American; Area; Asthma; Automobile Driving; Behavior; Chest; Chronic Obstructive Pulmonary Disease; Cross-Sectional Studies; Data; Development; Devices; Dose; Ecological momentary assessment; Electronic cigarette; Environment; Exhalation; Frequencies; Funding; Health; High School Student; Home; Impairment; Inflammation; Inhalation; Investigation; JUUL; Knowledge; Laboratories; Link; Longitudinal Studies; Lung; Lung diseases; Measurement; Measures; Mentorship; Methodology; Monitor; Nicotine; Nicotine Dependence; Nitric Oxide; Outcome; Participant; Patient Self-Report; Pattern; Perception; Peripheral; Persons; Population Assessment of Tobacco and Health; Postdoctoral Fellow; Prevalence; Regulation; Reporting; Research; Research Personnel; Resistance; Respiratory physiology; Role; Sampling; Smoker; Societies; Spirometry; Time; Tobacco; Tobacco use; Training; United States National Institutes of Health; Visit; Youth; base; design; electric impedance; electronic cigarette use; electronic cigarette user; high school; innovation; longitudinal design; lung health; novel; polytobacco use; prospective; pulmonary function; respiratory; respiratory health; response; skills; tobacco prevention; tobacco products; tobacco regulatory science; tobacco user; vaping

PROJECT ABSTRACT Electronic cigarettes (EC) remain the most commonly used product among high schoolers. Little is known about acute and longitudinal respiratory effects of ECs. This novel study will contribute critical knowledge needed to understand pulmonary functioning and respiratory effects among 150 youth who are exclusive-EC (N = 100) or never-users (N = 50; EC or other tobacco products), using a longitudinal, multimethod design. Youth will complete 5-laboratory assessments to provide a comprehensive assessment of respiratory health (airway reactivity and inflammation; pulmonary functioning). Further, we will incorporate EC user topography to assess the immediate acute effects of EC use on respiratory markers. Two weeks prior to laboratory assessments youth will complete daily EMA and spirometry assessments to examine how the frequency and quantity of EC use impairs acute pulmonary functioning. This Tobacco Regulatory K01 will provide much needed evidence regarding the immediate and longitudinal effects of EC use, while providing valuable training to a promising new investigator from leading experts in the field of tobacco regulatory science.

项目摘要 电子烟（EC）仍然是高中生最常用的产品。知之甚少 关于内皮细胞的急性和纵向呼吸效应。这项新的研究将有助于关键的知识 需要了解肺功能和呼吸系统的影响，150名青年谁是排他性的EC （N = 100）或从未使用者（N = 50; EC或其他烟草产品），使用纵向多方法设计。 青少年将完成5项实验室评估，全面评估呼吸系统健康 （气道反应性和炎症;肺功能）。此外，我们将把EC用户地形， 评估EC使用对呼吸标志物的即刻急性影响。实验室前两周 评估青少年将完成每日EMA和肺量测定评估，以检查频率和 大量使用EC会损害急性肺功能。烟草监管K 01将提供 需要关于使用EC的直接和纵向影响的证据，同时提供有价值的培训 感谢烟草监管科学领域领先专家的一位有前途的新研究员。