Respiratory effects of e-cigarette use among youth: a prospective, longitudinal investigation

青少年使用电子烟对呼吸系统的影响：前瞻性纵向调查

• 批准号: 10283173
• 负责人: Alayna Pauline Tackett
• 金额: $ 19.4万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-17 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10283173
• 关键词: Acute; Adolescence; Adolescent; Adult; Age; Airway Resistance; American; Area; Asthma; Automobile Driving; Behavior; Chest; Chronic Obstructive Pulmonary Disease; Cross-Sectional Studies; Data; Development; Devices; Dose; Ecological momentary assessment; Electronic cigarette; Environment; Exhalation; Frequencies; Funding; Health; High School Student; Home; Impairment; Inflammation; Inhalation; Investigation; JUUL; Knowledge; Laboratories; Link; Longitudinal Studies; Lung; Lung diseases; Measurement; Measures; Mentorship; Methodology; Methods; Monitor; Nicotine; Nicotine Dependence; Nitric Oxide; Outcome; Participant; Patient Self-Report; Pattern; Perception; Peripheral; Persons; Population Assessment of Tobacco and Health; Postdoctoral Fellow; Prevalence; Regulation; Reporting; Research; Research Personnel; Resistance; Respiratory physiology; Role; Sampling; Smoker; Societies; Spirometry; Time; Tobacco; Tobacco use; Training; United States National Institutes of Health; Visit; Youth; design; electric impedance; electronic cigarette use; electronic cigarette user; innovation; longitudinal design; lung health; novel; pod mods; polytobacco use; prospective; pulmonary function; respiratory; respiratory examination; respiratory health; response; skills; tobacco prevention; tobacco products; tobacco regulatory science; tobacco user; vaping

PROJECT ABSTRACT Electronic cigarettes (EC) remain the most commonly used product among high schoolers. Little is known about acute and longitudinal respiratory effects of ECs. This novel study will contribute critical knowledge needed to understand pulmonary functioning and respiratory effects among 150 youth who are exclusive-EC (N = 100) or never-users (N = 50; EC or other tobacco products), using a longitudinal, multimethod design. Youth will complete 5-laboratory assessments to provide a comprehensive assessment of respiratory health (airway reactivity and inflammation; pulmonary functioning). Further, we will incorporate EC user topography to assess the immediate acute effects of EC use on respiratory markers. Two weeks prior to laboratory assessments youth will complete daily EMA and spirometry assessments to examine how the frequency and quantity of EC use impairs acute pulmonary functioning. This Tobacco Regulatory K01 will provide much needed evidence regarding the immediate and longitudinal effects of EC use, while providing valuable training to a promising new investigator from leading experts in the field of tobacco regulatory science.

项目摘要 电子烟(EC)仍然是高中生最常用的产品。鲜为人知 关于ECS的急性和纵向呼吸效应。这项新颖的研究将有助于提供批判性知识 需要了解150名独家EC青年的肺功能和呼吸影响 (n=100)或从不吸食(N=50；EC或其他烟草制品)，采用纵向、多方法设计。 青少年将完成5个实验室的评估，以提供对呼吸健康的全面评估 (呼吸道反应性和炎症；肺功能)。此外，我们将把EC用户地形图纳入 评估EC使用对呼吸标志物的即刻急性影响。化验前两周 青少年将完成每天的EMA和肺活量测定评估，以检查频率和 EC使用量会损害急性肺功能。这一烟草监管机构K01将提供更多 需要关于使用EC的直接和纵向影响的证据，同时提供有价值的培训 一位来自烟草监管科学领域顶尖专家的有前途的新研究员。

项目成果

Appeal of e-cigarette flavors: Differences between never and ever use of combustible cigarettes.

电子烟口味的吸引力：从不使用和曾经使用过可燃香烟的区别。

• DOI: 10.1016/j.drugalcdep.2023.109849
• 发表时间: 2023
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Tackett,AlaynaP;Dai,HongyingDaisy;Han,Dae-Hee;Vogel,ErinA;Coreas,SaidaI;Jafarzadeh,Nikki;GonzalezAnaya,MariaJ;Patel,Devaki;Peraza,Natalia;Mason,TylerB;Leventhal,AdamM
• 通讯作者: Leventhal,AdamM

'Flavour ban approved': new marketing strategies from tobacco-free nicotine pouch maker Zyn.

“批准风味禁令”：无烟草袋制造商Zyn的新营销策略。

• DOI: 10.1136/tobaccocontrol-2021-057222
• 发表时间: 2023-04
• 期刊: TOBACCO CONTROL
• 影响因子: 5.2
• 作者: Tackett, Alayna P.;Barrington-Trimis, Jessica L.;Leventhal, Adam M.
• 通讯作者: Leventhal, Adam M.

Adolescent Susceptibility to E-Cigarettes: An Update From the 2018 National Youth Tobacco Survey.

• DOI: 10.1177/0890117120971121
• 发表时间: 2021-05
• 期刊: American journal of health promotion : AJHP
• 作者: Tackett AP;Keller-Hamilton B;Hébert ET;Smith CE;Wallace SW;Stevens EM;Johnson AL;Wagener TL
• 通讯作者: Wagener TL

Feasibility and acceptability of remote procedures to study tobacco product use and respiratory health: an observational study.

• DOI: 10.1136/bmjopen-2022-065962
• 发表时间: 2022-12-01
• 期刊: BMJ open
• 影响因子: 2.9

Youth use of e-cigarettes: Does dependence vary by device type?

• DOI: 10.1016/j.addbeh.2021.106918
• 发表时间: 2021-08
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: Tackett AP;Hébert ET;Smith CE;Wallace SW;Barrington-Trimis JL;Norris JE;Lechner WV;Stevens EM;Wagener TL
• 通讯作者: Wagener TL