SBIR TOPIC 107 MONOCLONAL ANTIBODIES FOR THE IMMUNE TARGETS OF SWINE

SBIR 主题 107 针对猪免疫目标的单克隆抗体

• 批准号: 10688719
• 负责人: HONG QI
• 金额: $ 60万
• 依托单位: QOOLABS, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10688719
• 关键词: Animal Model; Animal Sources; Antibodies; Antibody Formation; Biomedical Research; Cells; Disease; Family suidae; Health; Human; Immune; Immune Targeting; Immunologic Markers; Investigation; Monoclonal Antibodies; Oryctolagus cuniculus; Production; Reagent; Small Business Innovation Research Grant; Study models; Technology; Tissues; Xenograft procedure; organ transplant rejection; pre-clinical; tool

Swine is a useful animal model for studying human health and diseases. Particularly, swine is currently preferred candidate species as the source animal for xenotransplantation. However, the usefulness of pig for biomedical research has been constrained by the lack of reagents targeting immune markers involved in tissue/organ rejection. The objectives of this proposal are to generate rabbit monoclonal antibodies to selected swine immune markers that are related to xenotransplantation and to characterize the produced antibodies to demonstrate their reactivity with the appropriate swine immune cell subsets. Successful production of these antibodies will generate useful tools to promote pre-clinical biomedical research especially xenotransplantation investigations.

猪是研究人类健康和疾病的有用动物模型。特别地，猪是目前作为异种移植源动物的优选候选物种。然而，由于缺乏靶向组织/器官排斥反应中涉及的免疫标记物的试剂，猪用于生物医学研究的有用性受到限制。本提案的目的是针对与异种移植相关的选定猪免疫标志物生成兔单克隆抗体，并表征所生成的抗体，以证明其与适当的猪免疫细胞亚群的反应性。这些抗体的成功生产将产生有用的工具，以促进临床前生物医学研究，特别是异种移植研究。