Development of the golden Syrian hamster model of COVID-19

IRF建立了金色叙利亚仓鼠模型，再现了人类疾病的肺部病理特征。细胞因子反应和抗体反应也与人类疾病相似。正电子发射断层扫描与计算机断层扫描相结合，并进一步支持该模型用于临床前对策筛选。对老年仓鼠的进一步实验表明，疾病的严重程度增加了。老年受试者比年轻受试者表现出更多的肺部病理和更严重的体重下降。

The IRF established the golden Syrian hamster model which recapitulates lung pathology features of human disease. Cytokine response and antibody response also parallel human disease. Positron emission tomography with computed tomography was incorporated and indicated further support of this model for pre-clinical countermeasure screening. A further experiment using aged hamsters indicated increased disease severity. Aged subjects demonstrated increased lung pathology and more severe weight lost than younger subjects.