Development of the golden Syrian hamster model of COVID-19

COVID-19 叙利亚黄金仓鼠模型的开发

• 批准号: 10283148
• 负责人: Connie Schmaljohn
• 金额: $ 9.46万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10283148
• 关键词: Antibody Response; COVID-19; Development; Disease Progression; Hamsters; Magnetic Resonance Imaging; Medical Imaging; Mesocricetus auratus; Modeling; Pathogenesis; Positron-Emission Tomography; Pre-Clinical Model; Pulmonary Pathology; Severity of illness; Testing; Weight; X-Ray Computed Tomography; aged; cytokine; experimental study; human disease; response; screening; temporal measurement

The IRF established the golden Syrian hamster model which recapitulates lung pathology features of human disease. Cytokine response and antibody response also parallel human disease. Positron emission tomography with computed tomography was incorporated and indicated further support of this model for pre-clinical countermeasure screening. A further experiment using aged hamsters indicated increased disease severity. Aged subjects demonstrated increased lung pathology and more severe weight lost than younger subjects.

IRF建立了金黄色叙利亚仓鼠模型，该模型概括了人类疾病的肺部病理学特征。 细胞因子反应和抗体反应也与人类疾病平行。 正电子发射断层扫描与计算机断层扫描被纳入，并表示进一步支持该模型的临床前对策筛选。使用老年仓鼠的进一步实验表明疾病严重程度增加。与年轻受试者相比，老年受试者表现出肺部病理学增加和更严重的体重减轻。