Development of the Crab eating macaque model of COVID-19

COVID-19 食蟹猕猴模型的开发

• 批准号: 10285867
• 负责人: Connie Schmaljohn
• 金额: $ 12.16万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10285867
• 关键词: Antibody Response; COVID-19; Data; Development; Disease; Disease Progression; Disease regression; Human; Infection; Macaca; Macaca fascicularis; Modeling; Pathogenesis; Positron-Emission Tomography; Pulmonary Pathology; Safety; Serum; X-Ray Computed Tomography; coronavirus disease; cytokine; efficacy testing; imaging capabilities; neutralizing antibody; nonhuman primate; particle exposure

The IRF has established two crab-eating macaque models of COVID-19, intrabronchial exposure and small-particle exposure models. Data from both models support a mild to moderate disease that begins to regress by day 10 post-infection. However, lung pathology, as observed by positron emission tomography with computed tomography (PET/CT) is more severe in small-particle exposed macaques. In both models, lung pathology can be quantified using PET/CT, macaques develop a neutralizing antibody response, and serum cytokine dynamics are similar to what has been observed in humans. The data support that PET/CT or CT alone can be used to quantify disease progression and regression which can be used to evaluate countermeasure safety and efficacy.

IRF建立了两种食蟹猕猴COVID-19模型，支气管内暴露模型和小颗粒暴露模型。 来自两种模型的数据都支持轻度至中度疾病在感染后第10天开始消退。 然而，正如通过正电子发射断层扫描和计算机断层扫描（PET/CT）观察到的那样，在小颗粒暴露的猕猴中，肺部病理学更为严重。 在这两种模型中，肺部病理可以使用PET/CT定量，猕猴产生中和抗体反应，血清细胞因子动力学与在人类中观察到的相似。数据支持PET/CT或单独CT可用于量化疾病进展和消退，可用于评价对策的安全性和有效性。