Development of the Crab eating macaque model of COVID-19

国际癌症研究所已经建立了新冠肺炎的两种食蟹猕猴模型，即支气管内暴露模型和小颗粒暴露模型。这两个模型的数据都支持一种轻到中度的疾病，这种疾病在感染后第10天开始消退。然而，通过正电子发射断层扫描和计算机断层扫描(PET/CT)观察到的肺病理，在小颗粒暴露的猕猴中更为严重。在这两个模型中，肺病理可以使用PET/CT进行量化，猕猴产生中和抗体反应，血清细胞因子动态与在人类中观察到的相似。数据支持PET/CT或CT可单独用于量化疾病进展和消退，可用于评估对策的安全性和有效性。

The IRF has established two crab-eating macaque models of COVID-19, intrabronchial exposure and small-particle exposure models. Data from both models support a mild to moderate disease that begins to regress by day 10 post-infection. However, lung pathology, as observed by positron emission tomography with computed tomography (PET/CT) is more severe in small-particle exposed macaques. In both models, lung pathology can be quantified using PET/CT, macaques develop a neutralizing antibody response, and serum cytokine dynamics are similar to what has been observed in humans. The data support that PET/CT or CT alone can be used to quantify disease progression and regression which can be used to evaluate countermeasure safety and efficacy.