Cell factory of the future - scaling up culture of cells on bioemulsions

未来的细胞工厂——扩大生物乳液细胞培养规模

• 批准号: 10044539
• 金额: $ 6.36万
• 依托单位: LIQUIBIO
• 依托单位国家: 英国
• 项目类别: Grant for R&D
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10044539
• 关键词: Cell; factory; future; scaling; up

Meat production accounts for 60% of greenhouse gas emissions generated by global food production, which translates to 17.5B metric tonnes of emissions per year. This is on par with those from transportation. Replacing just 20% of farmed meat translates to removing emissions generated by 760M cars. To feed these animals, land has to be cleared for animal grazing and growing their feed. While more people turn vegetarian or vegan, a large majority still cannot forego meat in their daily diets. In the past decade, the cultivated meat (CM) industry has grown. Its ethos is to develop meat that is indistinguishable from farmed meat and aid us in reaching net-zero emissions through reduced land usage and more sustainable production processes. However, biomanufacturing capacity cannot keep up. Global bioreactor capacity is only at 15 million litres and by 2030, it is estimated that the demand will be 250 million litres. While most of the CM industry is focusing on bringing down cost through cell feed optimisation, the limitations and inefficiencies of current bioreactors and bioprocessing is often overlooked. Most of these bioreactors are adapted from the cell therapy industry with great losses at every bioprocessing step and fragmented overall process. As a result, price parity is still difficult to achieve due to the high cost of growing CM compared to farmed meat.We are transforming how we routinely grow mammalian cells in the lab by growing them on the surface of liquid droplets rather than solid substrates such as microcarriers. This project will focus on developing a bioreactor to complement the technology we have developed. This will allow us to showcase the scale up capabilities and streamlined bioprocessing required with our technology.As a cell manufacturing platform, new types of food can be developed, giving more variety, and allowing the gradual shift from traditional meat consumption. By accelerating product development, Liquibio aids in building a more resilient food system and lowering CO2 emissions.

肉类生产占全球粮食生产产生的温室气体排放量的60%，这相当于每年175亿公吨的排放量。这与交通运输业的情况不相上下。只需替换20%的养殖肉，就相当于减少了7.6亿辆汽车产生的排放。为了喂养这些动物，必须清理土地以供动物放牧和种植饲料。虽然越来越多的人成为素食主义者或纯素食主义者，但绝大多数人仍然不能在日常饮食中放弃肉类。在过去的十年里，培育肉(CM)产业得到了发展。它的理念是开发与养殖肉类没有区别的肉类，并通过减少土地使用和更可持续的生产过程来帮助我们实现净零排放。然而，生物制造能力跟不上。全球生物反应器的能力只有1500万升，到2030年，估计需求将达到2.5亿升。虽然大多数CM行业都专注于通过优化细胞饲料来降低成本，但目前生物反应器和生物处理的局限性和低效往往被忽视。这些生物反应器大多是从细胞治疗行业改装而来的，每一个生物处理步骤都有很大的损失，整个过程支离破碎。因此，价格平价仍然很难实现，因为与养殖肉类相比，种植CM的成本很高。我们正在改变我们在实验室中常规培养哺乳动物细胞的方式，将它们培养在液滴表面，而不是微载体等固体基质上。该项目将专注于开发一种生物反应器，以补充我们已经开发的技术。这将使我们能够展示我们的技术所需的放大能力和简化的生物加工。作为细胞制造平台，可以开发新类型的食品，提供更多种类，并允许逐步从传统的肉类消费转变。通过加快产品开发，LiquiBio有助于建立一个更具弹性的食品体系，并降低二氧化碳排放。