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Perioperative Cognitive Anesthesia Network Extension for Socially Vulnerable Older Adults

针对社会弱势老年人的围手术期认知麻醉网络扩展

基本信息

批准号：
10281822
负责人：
Patrick J Tighe
金额：
$ 15.47万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10281822
关键词：
Academic/Teacher Award Address Advisory Committees Age Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease related dementia Anesthesia procedures Anesthesiology Area Artificial Intelligence Awareness Basic Science Clinic Clinical Clinical Sciences Cognition Cognitive Collection Communities Conduction Anesthesia Data Data Linkages Data Science Databases Dementia Documentation Early Diagnosis Elderly Electricity Fellowship Florida Food Funding Geriatrics Grant Health Health system Healthcare Systems High Performance Computing Hospitals Impaired cognition Individual Infrastructure Interdisciplinary Study Investigation Lead Leadership Link Machine Learning Measures Medicine Mentorship Modeling Neighborhoods Nerve Degeneration Neurodegenerative Disorders Neuropsychology Operative Surgical Procedures Orthopedic Surgery Outcome Pain Pathway interactions Patients Performance Perioperative Perioperative Care Population Population Heterogeneity Postoperative Pain Postoperative Period Process Proxy Records Recovery Research Research Infrastructure Research Personnel Research Training Resources Role Scientist Secure Social Functioning Social Network Social support Structure Supplementation System Time TimeLine Training Training Programs Training and Infrastructure Transportation United States Centers for Medicare and Medicaid Services United States National Institutes of Health Update care systems certificate program clinical Diagnosis cognitive change cohort curriculum development data modeling deep learning deprivation disparity reduction experience frailty indexing learning strategy meetings mild cognitive impairment multidisciplinary neglect neuropathology novel postoperative recovery programs prospective provider factors recruit risk stratification sex social social determinants social disparities social factors social health determinants social vulnerability success surgery outcome symposium unstructured data

项目摘要

ABSTRACT The U.S. healthcare system cares for increasing numbers of older adults, including those with Alzheimer’s disease and related dementias, who require surgery with anesthesia. Regional social inequities, as measured by spatial indices such as area deprivation and social vulnerability indices, independently contribute to differences in perioperative and neurodegenerative outcomes. Data also support a significant association between neighborhood-level area deprivation indices with Alzheimer’s disease neuropathology. Despite emerging evidence linking social determinants of health with disparities in postoperative outcomes in older adults, investigations in these areas increasingly require expertise with disparate subject matters, including clinical perioperative practice, geriatrics, neuropsychology, social determinants of health, geospatial analyses, and even artificial intelligence. The K07 applicant is a National Institutes of Health (NIH)-funded independent investigator and fellowship-trained anesthesiologist with expertise in regional anesthesia and orthopedic surgery, as well as research experience in machine learning, geospatial disparities, and perioperative pain and cognition. The purpose of this proposal is to promote institutional and community awareness of how social vulnerabilities impact perioperative outcomes in older adults, including those with Alzheimer’s disease and related dementias, and particularly those outcomes related to postoperative pain and cognition. The overall strategy of this proposal is to develop interdisciplinary research infrastructure along with transdisciplinary training programs to crosspollinate research teams. This structure will be organized via the Perioperative Cognitive Anesthesia Network-Social Vulnerability (PeCANSV) construct in three aims: Aim 1: Convene a PeCANSV multidisciplinary advisory team to establish three supplemental cores in 1) geospatial infrastructure; 2) social determinants of health; 3) artificial intelligence. Aim 2: Accelerate research discovery through interdisciplinary research pathways by formalizing nascent linkages between supplemental PeCANSV cores and UF resources and extant geospatial, environmental, cognitive, and clinical perioperative databases at UF Health and throughout Florida. Aim 3: Develop a transdisciplinary workforce of clinical and basic science researchers to lead interdisciplinary teams addressing the social vulnerability of older adult surgical patients. Milestones include regular analysis of strengths, opportunities, aspirations, and results, interdisciplinary proposal submissions, and evidence of trainee success in perioperative research in social disparities of older adults, including those with Alzheimer’s disease and related dementias.

摘要