Health Aging & Later-Life Outcomes Planning (HALLO-P)
健康老龄化
基本信息
- 批准号:10282037
- 负责人:
- 金额:$ 110.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-15 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdherenceAdultAgeAgingAmericanAnimal ModelAttitudeBehavior TherapyBenefits and RisksBiological MarkersBiological ProcessBiometryBody Weight decreasedCaloric RestrictionCardiometabolic DiseaseClinicalClinical TrialsCompanionsComplexConsent FormsControl GroupsDataDatabasesDietary InterventionDiseaseDisease-Free SurvivalDoseEatingElderlyEnergy IntakeEnrollmentEpidemiologyEventExclusion CriteriaFocus GroupsFunding MechanismsGeroscienceGoalsGrantHealthHealth BenefitHourHumanImpairmentIndividualInterleukin-6Intermittent fastingInterventionIntervention TrialLiteratureLongevityMacronutrients NutritionManualsMeasuresMicronutrientsMild obesityMinorityModelingMuscleMuscle functionMuscular AtrophyObesityOutcomeOverweightParticipantPathway interactionsPatternPersonal SatisfactionPersonsPhysiologicalPilot ProjectsProcessProtocols documentationQuality ControlRandomizedRandomized Clinical TrialsRandomized Controlled Clinical TrialsRegimenReportingResearch PersonnelResourcesSiteStructureSystemTime-restricted feedingTranslatingVideoconferencingWeightWomanWorkage relatedattentional controlbehavior changeblood pressure reductionbonebone healthbone lossclinically relevantdata managementdesigndietarydisabilitydisability riskdisorder riskdoubly-labeled waterforestfracture riskfunctional declineglucose monitorhealthspanimprovedinnovationmHealthmultiple chronic conditionsmuscle metabolismobesity treatmentoperationrecruitremote deliveryrepositoryresponsetooltrial comparing
项目摘要
The Health, Aging and Later-Life Outcomes Planning Grant (HALLO-P) is submitted in response to
RFA-AG-21-016. Collectively, HALLO-P affiliated investigators have led 17 clinical trials of caloric restriction
(CR; 3 ongoing), enrolling 2,773 adults (ages 55-91) with BMIs ≥ 27 kg/m2, showing multiple beneficial
physiologic changes associated with lower disease and disability risk. Whether this translates to actual
reductions in disease and disability is unclear. A large multi-year trial with definitive clinical outcomes is needed
to fill this evidence gap. Time restricted feeding (TRF) could be an attractive alternative to CR if it produced
similar health benefits, was more easily sustained, and mitigated CR’s undesirable loss of muscle and bone.
The overall goal of this 3-year HALLO planning grant is to develop a protocol for a rigorous, multi-site,
randomized clinical trial (RCT) comparing clinically-relevant health outcomes in older persons randomized to
daily CR, a TRF regimen, or a non-dietary attention control group employing innovative mHealth tools to
promote adherence. We will complete a 12-month pilot study enrolling 120 older adults (age ≥60 years; 50%
women; ≥23% minority) to provide critical information on feasibility, intervention delivery, and data informing
effect size determination.
HALLO-P’s Objectives are to:
1. Establish a scientific advisory board and other structures to guide planning activities and the design of a full-
scale RCT that engage a wide range of stakeholders and build a national constituency for the project.
2. Refine our mHealth behavior-change and adherence tracking platform—the HALLO-P Companion App—to
optimize delivery of both the CR and TRF interventions.
3. Conduct focus groups and a 12-month pilot RCT of: 1) 20% CR delivered in-person; 2) 20% CR delivered
remotely via video conferencing; and 3) TRF (8-10 hours) with ad libitum caloric intake. Pilot data will help
refine recruitment criteria, estimate recruitment yields, and refine intervention approaches. We will use doubly-
labeled water to measure achieved CR and continuous glucose monitoring to assess adherence to TRF.
4. Model aging biomarker changes for differing CR doses using WF OAIC repositories and the HALLO-P pilot.
Existing epidemiological databases will be used to estimate the anticipated effect of these biomarker changes
on clinical outcomes and to derive key design metrics related to inclusion/exclusion criteria, and event rates
related to multi-morbidity, health deficit accumulation, and functional decline/disability; and
5. Integrate new data, the scientific literature .and expert advice to prepare a protocol, and develop informed
consent forms, manuals of operation, study forms, and related systems to permit the rapid launch of the larger
trial upon completion of the pilot activities in coordination with the other U01 project funded by this mechanism.
健康、老龄化和晚年生活成果规划补助金(halo - p)是根据以下情况提交的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
STEPHEN B. KRITCHEVSKY其他文献
STEPHEN B. KRITCHEVSKY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('STEPHEN B. KRITCHEVSKY', 18)}}的其他基金
Health Aging & Later-Life Outcomes Planning (HALLO-P)
健康老龄化
- 批准号:
10477330 - 财政年份:2021
- 资助金额:
$ 110.77万 - 项目类别:
The Mobile Devices for Meal Timing (MD4MT) Study: A supplement to HALLO-P using multiple wearable devise to improve accuracy in meal timing for older adults2
进餐时间移动设备 (MD4MT) 研究:HALLO-P 的补充,使用多个可穿戴设备提高老年人进餐时间的准确性2
- 批准号:
10709387 - 财政年份:2021
- 资助金额:
$ 110.77万 - 项目类别:
Health Aging & Later-Life Outcomes Planning (HALLO-P)
健康老龄化
- 批准号:
10906442 - 财政年份:2021
- 资助金额:
$ 110.77万 - 项目类别:
Health Aging & Later-Life Outcomes Planning (HALLO-P)
健康老龄化
- 批准号:
10674850 - 财政年份:2021
- 资助金额:
$ 110.77万 - 项目类别:
NCI Administrative Supplement for the HALLO-P Planning Project
NCI 针对 HALLO-P 规划项目的行政补充
- 批准号:
10844298 - 财政年份:2021
- 资助金额:
$ 110.77万 - 项目类别:
Developing an NIA Research Centers Collaborative Network (RCCN)
开发 NIA 研究中心协作网络 (RCCN)
- 批准号:
9904387 - 财政年份:2018
- 资助金额:
$ 110.77万 - 项目类别:
Brain Networks and Mobility Function: B-NET
大脑网络和移动功能:B-NET
- 批准号:
10189465 - 财政年份:2017
- 资助金额:
$ 110.77万 - 项目类别:
相似海外基金
Structural Racism, Pharmacy Closures and Disparities in Medication Adherence Among Older Adult Medicare Part-D Beneficiaries
结构性种族主义、药房关闭以及老年人医疗保险 D 部分受益人的药物依从性差异
- 批准号:
10568717 - 财政年份:2023
- 资助金额:
$ 110.77万 - 项目类别:
Medication Adherence and Cardio-Metabolic Control Indicators among Adult American Indians Receiving Tribal Health Services
接受部落卫生服务的成年美洲印第安人的药物依从性和心脏代谢控制指标
- 批准号:
10419967 - 财政年份:2022
- 资助金额:
$ 110.77万 - 项目类别:
Medication Adherence and Cardio-Metabolic Control Indicators among Adult American Indians Receiving Tribal Health Services
接受部落卫生服务的成年美洲印第安人的药物依从性和心脏代谢控制指标
- 批准号:
10592441 - 财政年份:2022
- 资助金额:
$ 110.77万 - 项目类别:
Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients
利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
- 批准号:
10369750 - 财政年份:2021
- 资助金额:
$ 110.77万 - 项目类别:
Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients
利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
- 批准号:
10633248 - 财政年份:2021
- 资助金额:
$ 110.77万 - 项目类别:
Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients
利用技术提高青少年和年轻肾移植或肝移植受者的药物依从性
- 批准号:
10487516 - 财政年份:2021
- 资助金额:
$ 110.77万 - 项目类别:
Mhealth for Pre-exposure Prophylaxis Adherence by Young Adult MSM
Mhealth 促进年轻 MSM 遵守暴露前预防
- 批准号:
10228564 - 财政年份:2018
- 资助金额:
$ 110.77万 - 项目类别:
Mhealth for Pre-exposure Prophylaxis Adherence by Young Adult MSM
Mhealth 促进年轻 MSM 遵守暴露前预防
- 批准号:
9347041 - 财政年份:2017
- 资助金额:
$ 110.77万 - 项目类别:
Mindfulness training with HIV-positive youth and adult family members to improve treatment adherence
对艾滋病毒呈阳性的青少年和成年家庭成员进行正念训练,以提高治疗依从性
- 批准号:
9480702 - 财政年份:2016
- 资助金额:
$ 110.77万 - 项目类别:
Mindfulness training with HIV-positive youth and adult family members to improve treatment adherence
对艾滋病毒呈阳性的青少年和成年家庭成员进行正念训练,以提高治疗依从性
- 批准号:
9906853 - 财政年份:2016
- 资助金额:
$ 110.77万 - 项目类别:














{{item.name}}会员




