Brain Networks and Mobility Function: B-NET

大脑网络和移动功能：B-NET

• 批准号: 10189465
• 负责人: STEPHEN B. KRITCHEVSKY
• 金额: $ 58.77万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10189465
• 关键词: Accounting; Address; Affect; Age; Anatomy; Anisotropy; Area; Brain; Brain region; Cardiovascular system; Characteristics; Communities; Community Networks; Complex; Data; Development; Elderly; Fiber; Functional Magnetic Resonance Imaging; Functional disorder; Gait; Health; Health Care Costs; Image; Impairment; Individual; Intervention; Knowledge; Lesion; Link; Lower Extremity; Magnetic Resonance Imaging; Measures; Motivation; Motor; Motor Cortex; Motor output; Neuraxis; Neurology; Outcome; Pattern; Performance; Physical Performance; Play; Public Health; Quality of life; Rest; Risk; Role; Science; Sensory; Skeletal Muscle; Structure; Techniques; Testing; Tissues; age related; aged; aging brain; brain volume; cardiovascular fitness; cohort; disability; environmental change; follow-up; forest; functional decline; imaging approach; improved mobility; innovation; muscle strength; neuroimaging; novel; novel strategies; prevent; response; sensory input; societal costs; therapy design; white matter; white matter damage

Project Summary/Abstract Declining mobility function is a common age-related phenomenon that is associated with reduced quality of life and high societal costs. Recently, the brain's critical role in mobility function has been recognized using imaging approaches assessing white matter characteristics. A new paradigm considering the brain as a complex network uses MRI to directly characterize the brain as a functional network. Brain Networks and Mobility Function: B-NET brings together national leaders in brain network science, neurology and mobility assessment to apply this innovative network paradigm to elucidate the aging brain's role in declining mobility. We propose that functional connectivity within and between the sensorimotor cortex -- community structure (SMC-CS) -- predicts declining mobility; and that SMC-CS will be associated with mobility independent of known relationships between white matter integrity and mobility function. B-Net will establish a cohort of 240 community-dwelling older adults (age range 70-85) and measure mobility function at baseline, 6, 18 and 30 months using the extended short physical performance battery (eSPPB). The MRI will be repeated at 30 months. B-Net's specific aims are to: Specific Aim 1. Determine the baseline association between SMC-CS and eSPPB score. We hypothesize that SMC-CS will be associated with eSPPB performance independent of known correlates of mobility function and white matter integrity (i.e. fractional anisotropy and white matter lesions). Specific Aim 2. Determine whether baseline SMC-CS predicts mobility decline. We hypothesize that poorer baseline SMC-CS will be predict declining eSPPB scores after accounting for known correlates of mobility impairment including white matter integrity, cardiovascular fitness, and muscle strength. Specific Aim 3. Repeat brain MRI imaging to determine the longitudinal association between changes in SMC-CS and changes in eSPPB score. We hypothesize that longitudinal declines in SMC-CS will be significantly associated with declining eSPPB performance independent of known correlates of lower extremity function decline and white matter integrity. B-NET tests a novel emerging paradigm regarding the CNS's role in age-related functional decline to support the development of innovative strategies to sustain mobility function in older adults, a critical public health need.

项目摘要/摘要 活动能力下降是一种常见的与年龄相关的现象，与生活质量下降有关 以及高昂的社会成本。最近，大脑在活动功能中的关键作用已经被认识到 评估脑白质特征的成像方法。一种新的范式将大脑视为 复杂网络使用磁共振成像来直接将大脑描述为一个功能网络。Brain Networks和 移动功能：B-Net汇聚了脑网络科学、神经学和移动性领域的国家领先者 评估应用这一创新的网络范例，以阐明老化的大脑在流动性下降中的作用。 我们提出感觉运动皮质内部和之间的功能连接--社区结构 (SMC-CS)--预测移动性下降；SMC-CS将与移动性无关 白质完整性和活动功能之间的已知关系。 B-Net将建立240名居住在社区的老年人(年龄范围为70-85岁)的队列，并衡量流动性 使用扩展的短物理性能电池(ESPPB)在基线、6个月、18个月和30个月时进行功能测试。这个 30个月后再进行核磁共振检查。B-Net的具体目标是： 具体目标1.确定SMC-CS和eSPPB评分之间的基线关联。我们假设 SMC-CS将与eSPPB性能相关联，而不依赖于移动性函数的已知相关性 以及脑白质完整性(即各向异性分数和脑白质损害)。 具体目标2.确定基线SMC-CS是否预测行动能力下降。我们假设更贫穷的人 在考虑了已知的移动性相关因素后，基线SMC-CS将预测eSPPB得分下降 损害包括白质完整性、心血管健康和肌肉力量。 特定目标3.重复脑MRI成像以确定 SMC-CS和eSPPB评分的变化。我们假设SMC-CS的纵向下降将是 与eSPPB表现下降显著相关，独立于已知的下肢相关因素 功能衰退和脑白质完整性。 B-net测试了一种关于中枢神经系统在与年龄相关的支持功能下降中的作用的新的新兴范式 制定创新战略以维持老年人的行动能力，这是一项关键的公共卫生 需要。