B-NET Administrative Supplement

项目概要/摘要 行动功能下降是一种常见的与年龄相关的现象，与 生活质量下降和社会成本高昂。最近，大脑在移动性中发挥着关键作用 功能已通过评估白质特征的成像方法来识别。 一种将大脑视为复杂网络的新范式使用基于 MRI 的方法来 直接将大脑表征为一个功能网络。大脑网络和移动功能： B-NET 汇集了脑网络科学和移动评估领域的国家领导者 应用这种创新的网络范例来阐明大脑在活动能力下降中的作用。我们 提出大脑区域内部和之间功能连接的变化支持 运动预示着流动性下降。我们假设与年龄相关的结构损伤会影响 移动性部分是通过降低感觉运动皮层（SMC）的群落结构来体现的 降低 SMC 模块化并增加 SMC 与其他大脑区域的连接。 B-Net 建立了一个由 192 名社区老年人（年龄范围 70-85 岁）组成的队列， 使用延长的短期体能测量基线、6、18 和 30 个月时的活动功能 高性能电池（eSPPB）来解决以下特定目标。

Project Summary/Abstract Declining mobility function is a common age-related phenomenon that is associated with reduced quality of life and high societal costs. Recently, the brain's critical role in mobility function has been recognized using imaging approaches assessing white matter characteristics. A new paradigm considering the brain as acomplex network uses MRI-based approaches to directly characterize the brain as a functional network. Brain Networks and Mobility Function: B-NET brings together national leaders in brain network science and mobility assessment to apply this innovative network paradigm to elucidate the brain's role in declining mobility. We propose that changes in functional connectivity within and between brain regions supporting movement predict declining mobility. We hypothesize that age-related structural damage affects mobility, in part, by degrading the community structure of sensorimotor cortex (SMC) reflected in lower SMC modularity and increased SMC connectivity to other brain regions. B-Net established a cohort of 192 community-dwelling older adults (age range 70-85) and measure mobility function at baseline, 6, 18 and 30 months using the extended short physical performance battery (eSPPB) to address the following specific aims.