B-NET Administrative Supplement

项目概要/摘要 运动功能下降是一种常见的年龄相关现象，与 生活质量下降，社会成本高。最近，大脑在运动中的关键作用 已经使用评估白色物质特征的成像方法来识别功能。 一种将大脑视为复杂网络的新范式使用基于MRI的方法， 直接将大脑描述为一个功能网络。大脑网络和运动功能： B-NET汇集了脑网络科学和移动性评估方面的国家领导人， 应用这种创新的网络范式来阐明大脑在流动性下降中的作用。我们 提出大脑区域内部和之间的功能连接的变化， 运动预示着流动性下降。我们假设与年龄相关的结构损伤 运动，部分是通过降解感觉运动皮层（SMC）的社区结构，反映在 降低SMC模块化和增加SMC与其他脑区的连接。 B-Net建立了一个由192名社区老年人（年龄范围70-85岁）组成的队列， 在基线、6个月、18个月和30个月时使用扩展的短体格检查测量活动功能。 性能电池（eSPPB），以解决以下具体目标。

Project Summary/Abstract Declining mobility function is a common age-related phenomenon that is associated with reduced quality of life and high societal costs. Recently, the brain's critical role in mobility function has been recognized using imaging approaches assessing white matter characteristics. A new paradigm considering the brain as acomplex network uses MRI-based approaches to directly characterize the brain as a functional network. Brain Networks and Mobility Function: B-NET brings together national leaders in brain network science and mobility assessment to apply this innovative network paradigm to elucidate the brain's role in declining mobility. We propose that changes in functional connectivity within and between brain regions supporting movement predict declining mobility. We hypothesize that age-related structural damage affects mobility, in part, by degrading the community structure of sensorimotor cortex (SMC) reflected in lower SMC modularity and increased SMC connectivity to other brain regions. B-Net established a cohort of 192 community-dwelling older adults (age range 70-85) and measure mobility function at baseline, 6, 18 and 30 months using the extended short physical performance battery (eSPPB) to address the following specific aims.