Platform for ultra-high resolution multi-modal investigations of brain function in the non-human primate at 10.5 T

项目摘要 非人灵长类动物提供了一个独特的机会，因为它们在生理和行为上有很强的同源性 对人类来说，既是为了促进我们对神经科学和测试疗法基本问题的理解，也是为了促进我们对 具有直接临床影响的战略，以解决一系列精神健康问题。中的“缺少的环节” 这些努力一直无法使用人类神经科学的主要技术，包括非侵入性技术 核磁共振成像(MRI)，在猴子身上。如果没有这样的能力，我们对信号的直接比较 在人类身上进行测量，以及那些只有更具侵入性的方法，如通过电生理、组织学和 逻辑的和优化的方法是不可能的。为了避免潜在的投机性建模，信息量最大的 多模式测量需要可比较的空间和时间尺度的研究。因此，该申诉人- NIMH已经认识到了这种高分辨率多模式成像的重要性：它是 目前的一些项目，包括几个由大脑倡议赞助的项目。在磁共振中心- Nance Research，我们已经证明了一种独特的资源，10.5 Telsa磁共振扫描仪，可以将MRI推向空间 在非人类灵长类动物中，时间分辨率达到无与伦比的水平，直接与侵入性 测量。为了最大限度地利用这一独特资源对科学fic语言的影响，我们寻求共享工具。 在10.5T中从非人灵长类动物获得高分辨率电生理和光学数据所必需的 扫描仪。该中心有着悠久的传统，向 通过包括P41和P30在内的核心赠款扩大社区。在这项提案中，我们利用这一传统来 确保所需设备支持广泛的NIMH项目，旨在了解 人类大脑功能的信号和电路。

Project Summary Non-human primates offer a unique opportunity, because of their strong physiological and behavioral homologies to humans, to both advance our understanding of fundamental issues of neuroscience and test therapies and strategies with direct clinical implications for addressing a spectrum of mental health issues. A “missing link” in such efforts has been the inability to use the primary techniques of human neuroscience, including non-invasive magnetic resonance imaging (MRI), on monkeys. Without such capabilities, a direct comparison of the signals we measure in humans, and those that only available more invasively, such as through electrophysiological, histo- logical, and optical methodologies, is impossible. To avoid potentially speculative modeling, the most informative multi-modal measurements require comparable spatial and temporal scales of study. Accordingly, the impor- tance of such high resolution multi-modal imaging has been recognized by the NIMH: it is a vital component of a number of current projects, including several sponsored by the BRAIN initiative. At the Center for Magnetic Reso- nance Research, we have demonstrated that a unique resource, a 10.5 Telsa MR scanner, can push MRI spatial and temporal resolution to unparalleled levels in non-human primates which are directly comparable to invasive measurements. To maximize the scientific impact of this unique resource, we seek the shared instrumentation necessary to obtain high-resolution electrophysiological and optical data from non-human primates in the 10.5 T scanner. The center has a long tradition of making its unique technical and personnel resources available to the broader community through core grants including a P41 and a P30. In this proposal, we leverage this tradition to ensure that the requested equipment supports a broad spectrum of NIMH projects aimed at understanding the signals and circuitry underlying human brain function.