Platform for ultra-high resolution multi-modal investigations of brain function in the non-human primate at 10.5 T

项目摘要 非人类灵长类动物提供了一个独特的机会，因为它们具有很强的生理和行为同源性 对人类来说，既可以促进我们对神经科学和测试疗法的基本问题的理解， 具有直接临床意义的战略，以解决一系列心理健康问题。一个“缺失的环节”， 这些努力一直无法使用人类神经科学的主要技术，包括非侵入性 磁共振成像（MRI），在猴子身上。如果没有这种能力，直接比较信号， 在人类中测量，以及那些只有更具侵入性的方法，例如通过电生理学，组织学， 逻辑和光学方法是不可能的。为了避免潜在的投机性建模， 多模式测量要求研究的空间和时间尺度具有可比性。因此，重要的是， NIMH已经认识到这种高分辨率多模态成像的重要性：它是一个重要的组成部分， 目前的一些项目，包括由BRAIN倡议赞助的几个项目。在磁共振中心（Center for Magnetic Reso）， nance研究，我们已经证明，一个独特的资源，10.5 Telsa MR扫描仪，可以推动MRI空间 和时间分辨率，以无与伦比的水平，在非人类灵长类动物，这是直接可比的入侵 测量.为了最大限度地发挥这一独特资源的科学影响，我们寻求共享仪器 在10.5 T的条件下，从非人类灵长类动物中获得高分辨率的电生理和光学数据是必要的。 扫描仪该中心有着悠久的传统，使其独特的技术和人力资源， 更广泛的社区通过核心赠款，包括P41和P30。在本提案中，我们利用这一传统， 确保所要求的设备支持广泛的NIMH项目，旨在了解 信号和电路的基本人脑功能。

Project Summary Non-human primates offer a unique opportunity, because of their strong physiological and behavioral homologies to humans, to both advance our understanding of fundamental issues of neuroscience and test therapies and strategies with direct clinical implications for addressing a spectrum of mental health issues. A “missing link” in such efforts has been the inability to use the primary techniques of human neuroscience, including non-invasive magnetic resonance imaging (MRI), on monkeys. Without such capabilities, a direct comparison of the signals we measure in humans, and those that only available more invasively, such as through electrophysiological, histo- logical, and optical methodologies, is impossible. To avoid potentially speculative modeling, the most informative multi-modal measurements require comparable spatial and temporal scales of study. Accordingly, the impor- tance of such high resolution multi-modal imaging has been recognized by the NIMH: it is a vital component of a number of current projects, including several sponsored by the BRAIN initiative. At the Center for Magnetic Reso- nance Research, we have demonstrated that a unique resource, a 10.5 Telsa MR scanner, can push MRI spatial and temporal resolution to unparalleled levels in non-human primates which are directly comparable to invasive measurements. To maximize the scientific impact of this unique resource, we seek the shared instrumentation necessary to obtain high-resolution electrophysiological and optical data from non-human primates in the 10.5 T scanner. The center has a long tradition of making its unique technical and personnel resources available to the broader community through core grants including a P41 and a P30. In this proposal, we leverage this tradition to ensure that the requested equipment supports a broad spectrum of NIMH projects aimed at understanding the signals and circuitry underlying human brain function.