Core 3 - Multi-Modal

尽管磁共振技术为非侵入性活体全脑提供了巨大的潜力 测量，当结合起来时，测量的解释可以大大增强 用经典的神经科学技术。例如，尽管MR特别适合于 对神经元化学或活动的群体水平研究，其时间分辨率通常受到以下因素的限制 血流动力学因素。通过结合高时间分辨率电生理学，例如由 细胞外或脑电电极，结合磁共振测量，更完整地了解大脑 新陈代谢和功能是可能的。这种多式联运调查的一个传统挑战是 神经科学研究人员在尝试最先进的MR时面临的高门槛 技巧。这一核心的目的是通过鼓励和支持来降低这种进入壁垒 CMRR提供的尖端磁共振方法与传统神经科学的结合 方法论。这些方法包括行为测量、电生理学、 组织化学、光学成像和轨迹追踪。因为核心成功地支持了 正如我们的使用表中所记录的那样，我们建议继续努力 通过人力和设备资源促进MR技术的结合，并 协助设计和实施多式联运

Although MR techniques offer enormous potential for non-invasive in-vivo whole brain measurements, the interpretation of the measurements can be greatly enhanced when combined with classical neuroscience techniques. For example, although MR is particularly well suited for population level studies of neuronal chemistry or activity, its temporal resolution is often limited by hemodynamic factors. By combining high temporal resolution electrophysiology, such as provided by extracellular or EEG electrodes, with MR measurements, a more complete picture of brain metabolism and function is possible. One traditional challenge for such multimodal investigations is the high barrier to entry that neuroscience investigators face in trying to state-of-the-art MR techniques. The purpose of this core is to reduce this barrier to entry by encouraging and supporting the integration of the cutting-edge MR methods available at the CMRR with traditional neuroscience methodologies. This methodologies include behavioral measurements, electrophysiology, histochemistry, optical imaging, and tract tracing. Because of the success of the core in supporting a variety of such projects, as is documented in our Usage Tables, we propose to continue our efforts through human and equipment resources to promote the incorporation of MR techniques, and to assist in the design and implementation of multimodal