Neuromodulation of affective valence in humans by amygdala stimulation

通过杏仁核刺激对人类情感效价的神经调节

• 批准号: 10282846
• 负责人: Krzysztof Bujarski
• 金额: $ 23.27万
• 依托单位: DARTMOUTH-HITCHCOCK CLINIC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-11 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10282846
• 关键词: Affect; Affective; Amygdaloid structure; Arousal; Behavior; Brain; Cell Nucleus; Clinical Trials; Cognition; Data; Deep Brain Stimulation; Development; Electric Stimulation; Electrodes; Electroencephalography; Emotional; Epilepsy; Event; Foundations; Functional Imaging; Functional disorder; Future; Goals; Human; Hyperactivity; Image; Insula of Reil; Intervention; Judgment; Knowledge; Measures; Mental disorders; Methods; National Institute of Mental Health; Negative Valence; Outcome; Pathologic; Patients; Perception; Performance; Pharmacologic Substance; Play; Positive Valence; Post-Traumatic Stress Disorders; Prefrontal Cortex; Process; Property; Psychotherapy; Research; Research Domain Criteria; Role; Techniques; Testing; Therapeutic; Transcranial magnetic stimulation; base; burden of illness; cingulate gyrus; disability-adjusted life years; effective intervention; improved; improved functioning; innovation; neural circuit; neural network; neuroregulation; novel; prefrontal lobe; relating to nervous system; side effect; standard care; years of life lost

PROJECT SUMMARY: Neuromodulation of affective valence in humans by amygdala stimulation Studies investigating global burden of disease have shown that a significant proportion of all disability- adjusted life years are lost due to uncontrolled mental health disorders. For patients with mental illness who have not benefited from conventional psychiatric interventions, neuromodulation via deep brain stimulation (DBS) is an emerging treatment option. Multiple lines of evidence show that dysfunction of the human amygdala plays a pivotal role in the pathophysiology of many psychiatric disorders The long- term goal is to determine if the human amygdala can be a suitable DBS target to treat psychiatric disorders. The main objective for this application is to take advantage of opportunity in patients who have intracranial electrodes for epilepsy to investigate how the amygdala processes affective valence and to determine if electrical stimulation targeted to the basolateral nucleus of the amygdala can be safely used to induce a change in neural network for valence perception and on judgment of affective valence. Our central hypothesis is that electrical stimulation of the basolateral nucleus of the amygdala during performance of an affective valence perception task will change the oscillatory properties of the valence network and in turn change how patients perceive affective valence in pictures without causing the undesirable side effects of stimulation. We propose that the induction of this effect on cognition will have future implications for the treatment of specific psychiatric disorders that are known to involve the amygdala. The central hypothesis will be tested by pursuing two specific aims: (1) Characterize oscillations of the valence network during judgment of valence; (2A) measure the effect of stimulation of the basolateral nucleus of the amygdala on the oscillatory properties of the valence network; and (2B) measure the effect of basolateral nucleus of the amygdala stimulation on perception of affective valence. For Aim 1, we record and analyze intracranial EEG during perception of the Judgment of Valence and Arousal Task to gain better understanding of the oscillatory markers of affective valence. For the Aim 2A, we will use inhibitory stimulation parameters and intracranial EEG to understand how stimulation of the basolateral nucleus of the amygdala affects the oscillatory properties of neural networks for representation of valence. For Aim 2B, we will determine how stimulation affects perception and judgment of valence. The research is innovative because it uses intracranial EEG to gain understanding of neural representation of valence and how stimulation effects neural networks and behavior. The proposed research is significant because it will improve our understanding of neural representation of valence and effect of stimulation parameters on neural network. The research will provide a strong foundation for future development of amygdala DBS for the treatment of specific psychiatric disorders.

项目概要：杏仁核刺激对人类情感效价的神经调节 调查全球疾病负担的研究表明，在所有残疾人中， 调整生命年因不受控制的精神健康障碍而丧失。对于精神病患者来说 没有从传统的精神病干预中受益，通过大脑深部神经调节 刺激（DBS）是一种新兴的治疗选择。多种证据表明， 人类杏仁核在许多精神疾病的病理生理学中起着关键作用。 长期目标是确定人类杏仁核是否可以成为治疗精神疾病的合适DBS靶点， 紊乱本申请的主要目的是利用患者的机会， 用颅内电极治疗癫痫，以研究杏仁核如何处理情感效价 并确定针对杏仁核基底外侧核的电刺激是否可以安全地 用于诱导神经网络中的变化，用于效价感知和情感效价的判断。 我们的中心假设是，在大脑皮层的杏仁核基底外侧核的电刺激， 情感效价知觉任务的执行将改变效价的振荡特性， 网络，并反过来改变患者如何感知图片中的情感效价，而不会导致 刺激的不良副作用。我们认为，这种对认知的影响的诱导将具有 未来的影响，为治疗特定的精神疾病，已知涉及的 杏仁核中心假设将通过追求两个具体目标进行测试：（1）表征 （2A）在判断化合价期间测量化合价网络的振荡; 杏仁核基底外侧核对价网络振荡特性的影响;以及（2B） 测量刺激杏仁基底外侧核对情感效价知觉的影响。 对于目标1，我们记录并分析了在感知效价判断时的颅内EEG， 唤醒任务，以获得更好的理解情感效价的振荡标记。为了目标 2A，我们将使用抑制性刺激参数和颅内EEG来了解刺激 杏仁核的基底外侧核影响神经网络的振荡特性， 表示价。对于目标2B，我们将确定刺激如何影响感知和判断 价。这项研究具有创新性，因为它使用颅内脑电图来了解神经系统 代表价和刺激如何影响神经网络和行为。拟议 这项研究意义重大，因为它将提高我们对效价神经表征的理解， 刺激参数对神经网络的影响。这项研究将为以下方面提供坚实的基础： 杏仁核DBS治疗特定精神疾病的未来发展。