Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement Core

生物医学信息学、生物信息学和网络基础设施增强项目摘要 生物医学信息学、生物信息学和网络基础设施增强(BIBCE)核心提供 面向大平原(GP)IDEA的强大而灵活的生物医学信息学基础设施-CTR成员具有 生物、临床和公共卫生信息学领域的尖端支持工具、专业知识和培训。 临床实践中对遗传和分子数据的广泛依赖已经成为健康游戏规则的改变者 护理实践，特别是在新兴的精准医学领域。因此，临床和转化性研究 (CTR)需要从数据收集和分析到数据集成和关联的一系列支持才能 有效的临床相关推论。然而，对个别机构来说，要在本地发展是极具挑战性的。 在这个快速变化的领域发展和维护复杂的基础设施和技术专长。这个 BIBCE核心的主要目标是开发这样的环境、专业知识、工具和服务，并 使它们在全科医生IDEA-CTR网络的所有机构中都可以访问。从以下位置收集和连接数据 从分子水平到种群水平，BIBCE核心将提供一套强大的工具来 区域CTR努力建设GP IDEA-CTR网络的整体CTR能力。而内布拉斯加州 拥有广泛的远程医疗网络，将所有公共教育设施和医院、信息学工具 和专家支持对于在CTR中产生多机构协作和拥有集中的 支撑的核心将是完成GP IDEA-CTR使命的关键。BIBCE核心将支持这一点 任务有四个具体目标：1)通过利用现有基础设施、网络、 以及GP IDEA-CTR、机构和其他IDEA资助项目之间的创造性合作；2)整合 并简化对基于基因组学和社区健康数据、生物库和注册中心、电子健康 整个网络的记录和决策支持系统，以促进翻译的精准健康研究； 3)将临床信息学资源与CTSA的国家健康数据中心(CD2H)等连接起来 CTR中心，便于访问并促进可行性研究、成果研究和CTR；以及4) 利用网络基础设施支持数据共享、知识和资源共享以及培训 全科医生IDEA-CTR网络中的农村和服务不足的人口。BIBCE核心将具有深远的 通过增强在以下领域的整体研究能力对GP IDEA-CTR成功的影响 临床、转换和精确健康；通过团队科学加强内部和 跨思想网络；精简各种信息学资源；使区域CTR与国家CTR保持一致 努力实现互操作性；通过新的课程和培训活动分享知识；最后，发展 远程保健工具，以接触到农村和服务不足的人口。

Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement Project Summary The Biomedical Informatics, Bioinformatics, and Cyberinfrastructure Enhancement (BIBCE) Core offers a robust and agile biomedical informatics infrastructure for the Great Plains (GP) IDeA-CTR members with cutting-edge support tools, expertise and training across bio-, clinical-, and public health informatics realms. Extensive reliance on genetic and molecular data in clinical practice has become a game-changer in health care practice, especially, in the emerging field of precision medicine. Hence, clinical and translational research (CTR) needs a range of supports from data collection and analysis to data integration and correlation to make clinically relevant inferences effectively. However, it is extremely challenging for individual institutions to locally develop and maintain sophisticated infrastructure and technical expertise in this rapidly changing field. The primary objective of the BIBCE Core is to develop such an environment, expertise, tools, and services and make them accessible across all institutions of the GP IDeA-CTR network. Collecting and connecting data from the molecular level to population level, the BIBCE Core will provide access to a robust suite of tools for regional CTR endeavors while building the overall CTR capacity of the GP IDeA-CTR network. While Nebraska has an extensive telehealth network that links all public educational facilities and hospitals, informatics tools and expert support are essential to generate multi-institutional collaborations in CTR and having a centrally supported core will be pivotal to accomplish the mission of GP IDeA-CTR. The BIBCE Core will support this mission with four specific aims: 1) Augment CTR capacity by leveraging existing infrastructure, networking, and creative collaborations among GP IDeA-CTR, institutional, and other IDeA-funded projects; 2) Integrate and streamline access to genomics-based and community health data, biobanks & registries, electronic health records, and decision support systems across the network to promote translational precision health research; 3) Connect the clinical informatics resources with CTSA’s National Center for Data to Health (CD2H) and other CTR centers to facilitate easy access and stimulate feasibility studies, outcomes research, and CTR; and 4) Support data sharing, knowledge and resource sharing, and training using cyberinfrastructure to reach out to the rural and underserved populations in the GP IDeA-CTR network. The BIBCE Core will have a profound impact on the success of GP IDeA-CTR through augmenting the overall research capacity in the realms of clinical, translational, and precision health; bolstering collaborations through team science within as well as across the IDeA networks; streamlining diverse informatics resources; aligning the regional CTR with national efforts for interoperability; sharing knowledge with new courses and training activities; and finally, developing telehealth tools to reach out to the rural and underserved populations.