Core C: Bioinformatics and Genomics Core

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Project Summary/Abstract – Core C Bioinformatics has become an integral part of biological research due to the high-throughput nature of multi-omics experiments warranting the need for having the infrastructure and trained personnel to support the advancement of science of the research projects. The Bioinformatics and Genomics Core (Core C) will continue to serve as a linchpin in the overall success of the program project by supporting the generation, storage, processing, analysis and accessing of experimental data. Core C will be led by Drs. Babu Guda and James Eudy, who will provide complementary expertise in Bioinformatics and Genomics areas, respectively. This Core is innovative by having a fully integrated Bioinformatics as well as Genomics units within, which allows full spectrum access to cutting-edge experimental and analytical techniques under one Core. The specific aims are: Aim 1: Support the sequencing and analysis of multi-omics data for research projects. Aim 2: Integrative analysis and functional characterization of significant genes, gene products, enriched pathways, and upstream regulators for hypothesis generation and testing. Aim 3: Develop a web portal to centralize access to multi-omics data from all research projects and to facilitate bioinformatics training activities. Core C will make a big impact on the overall success of the project by providing resources, personnel support and developing cutting-edge technologies and custom data analysis methods for all research projects. Proposed cloud-based web portal backed by a searchable database provides easy access to all experimental data, metadata, and the training materials facilitating synergistic interactions among the project personnel across multiple sites.