Core C: Bioinformatics and Genomics Core

核心 C：生物信息学和基因组学核心

• 批准号: 10627091
• 负责人: CHITTIBABU GUDA
• 金额: $ 32.34万
• 依托单位: WICHITA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-15 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627091
• 关键词: ATAC-seq; Aging; Archives; Area; Bioinformatics; Cells; Characteristics; Chromatin; Collaborations; Communities; Core Facility; Cryoelectron Microscopy; Custom; Data; Data Analyses; Data Set; Databases; Distant; Educational workshop; Environment; Epigenetic Process; Family suidae; Gene Expression; Gene Expression Profile; Generations; Genes; Genomics; Geographic Locations; Goals; Human; Human Resources; Image; Individual; Link; Location; Maps; Mass Spectrum Analysis; Medical center; Metadata; Methods; Modeling; Multiomic Data; Mus; Nature; Nebraska; Pathway Analysis; Pathway interactions; Pituitary Gland; Polysaccharides; Proteomics; Protocols documentation; Rattus; Research; Research Project Grants; Resources; Sampling; Science; Signal Transduction; Site; Structure; Techniques; Technology; Testing; Tissues; Training; Training Activity; Training and Infrastructure; Universities; Validation; Variant; Visualization; bioinformatics tool; biological research; cloud based; computer infrastructure; data access; data analysis pipeline; differential expression; experimental analysis; experimental study; gene product; glycosylation; innovation; miRNA expression profiling; multiple omics; next generation sequencing; programs; protein expression; searchable database; single-cell RNA sequencing; success; tool; training project; transcriptome sequencing; transcriptomics; web interface; web portal; web services; webinar

Project Summary/Abstract – Core C Bioinformatics has become an integral part of biological research due to the high-throughput nature of multi-omics experiments warranting the need for having the infrastructure and trained personnel to support the advancement of science of the research projects. The Bioinformatics and Genomics Core (Core C) will continue to serve as a linchpin in the overall success of the program project by supporting the generation, storage, processing, analysis and accessing of experimental data. Core C will be led by Drs. Babu Guda and James Eudy, who will provide complementary expertise in Bioinformatics and Genomics areas, respectively. This Core is innovative by having a fully integrated Bioinformatics as well as Genomics units within, which allows full spectrum access to cutting-edge experimental and analytical techniques under one Core. The specific aims are: Aim 1: Support the sequencing and analysis of multi-omics data for research projects. Aim 2: Integrative analysis and functional characterization of significant genes, gene products, enriched pathways, and upstream regulators for hypothesis generation and testing. Aim 3: Develop a web portal to centralize access to multi-omics data from all research projects and to facilitate bioinformatics training activities. Core C will make a big impact on the overall success of the project by providing resources, personnel support and developing cutting-edge technologies and custom data analysis methods for all research projects. Proposed cloud-based web portal backed by a searchable database provides easy access to all experimental data, metadata, and the training materials facilitating synergistic interactions among the project personnel across multiple sites.

项目摘要/摘要 - 核心C 由于高通量性质，生物信息学已成为生物学研究的组成部分 多媒体实验警告需要建立基础架构和训练有素的人员 支持研究项目的科学发展。生物信息学和基因组学 核心（核心C）将继续作为该计划项目的整体成功的关键 支持实验数据的生成，存储，处理，分析和访问。核 C将由博士领导。 Babu Guda和James Eudy将提供完整的专业知识 生物信息学和基因组学领域。通过完全集成，该核心具有创新性 内部的生物信息学和基因组学单元，可以全面访问前沿 一个核心下的实验和分析技术。具体目的是：目标1：支持 用于研究项目的多词数据的测序和分析。目标2：综合分析和 重要基因，基因产物，丰富途径和上游的功能表征 假设产生和检验的调节剂。目标3：开发一个网站以集中访问 来自所有研究项目的多摩斯数据，并促进生物信息学培训活动。 Core C Will 通过提供资源，人员支持和 为所有研究项目开发尖端技术和自定义数据分析方法。 由可搜索数据库支持的基于云的Web门户网站可轻松访问所有 实验数据，元数据和培训材料支持协同相互作用 跨多个站点的项目人员。