Mississippi Center for Clinical and Translational Research

项目总结。密西西比州的健康状况在全国名列前茅， 联合健康基金会被评为2019年最差健康状态此外，围绕这些地区的种族差距 健康后果是深远的。与有效解决密西西比州人健康问题相关的复杂性 结果和改善密西西比州的健康差距需要强有力的、多学科的研究和 外展基础设施。密西西比州临床和翻译研究中心(MCCTR) 成立于2016年，旨在提供这一基础设施，为研究人员提供进行 临床、转化和基于人群的研究项目。MCCTR建议继续和扩大 它所做的努力被称为“第二阶段”。在第二阶段，MCCTR将增加两个新的机构合作伙伴， 密西西比州立大学和密西西比大学牛津分校致其第一阶段合作伙伴密西西比大学 医学中心、图加鲁学院和南密西西比大学。它还将增加两个CTR/CTSA，作为 合作伙伴，阿拉巴马大学伯明翰临床和翻译科学中心 以及西北大学临床和翻译科学，致其第一阶段合作伙伴：梅奥诊所中心 和路易斯安那州临床和翻译科学中心。 行政核心将负责管理行政、财政和科学方面的工作 MCCTR，包括监督、营销和协调所有MCCTR核心和活动。这个 专业发展核心将提供结构化的指导、培训机会和受保护的研究 MCCTR伙伴机构的早期调查时间到了。社区参与和外展 CORE将为调查人员提供进行社区参与研究的培训和支持；合作伙伴 通过其新的以实践为基础的研究网络提供医疗保健服务；并与其扩大的社区合作 咨询委员会，就社区价值观、关切事项和 需要并代表密西西比州社区的MCCTR。生物统计学、流行病学和研究 设计核心将提供研究设计、数据收集和管理方面的培训和协助，以及 统计分析，以提高MCCTR进行的研究的有效性、效率和成功率 调查人员。试点项目计划将支持临床、翻译和基于人群的研究 可能对密西西比州的健康结果产生重大影响并导致外部资金的项目。这个 研究服务核心将通过研究协调和监管支持来支持研究项目，并 将通过扩大远程保健和队列研究资源，帮助将研究人员与社区联系起来。最后， 跟踪和评估核心将提供有关MCCTR性能和 对领导和咨询机构的规划和实施提供信息的影响。通过以下基础设施 MCCTR开发的资源和人员将对密西西比州的健康结果产生积极影响。

PROJECT SUMMARY. Mississippi has some of the nation's worst health outcomes and was ranked by the United Health Foundation as the “least healthy state” in 2019. Further, the racial disparities surrounding these health outcomes are profound. The complexities associated with effectively addressing Mississippians' health outcomes and ameliorating Mississippi's health disparities necessitate a strong, multi-disciplinary research and outreach infrastructure. The Mississippi Center for Clinical and Translational Research (MCCTR) was established in 2016 to provide this infrastructure, equipping researchers with the resources needed to conduct clinical, translational, and population-based research projects. The MCCTR proposes to continue and expand its efforts through what it has termed as “Phase II.” In Phase II, the MCCTR will add two new institutional partners, Mississippi State University and University of Mississippi-Oxford, to its Phase I partners, University of Mississippi Medical Center, Tougaloo College, and University of Southern Mississippi. It will also add two CTR/CTSAs as collaborating partners, the University of Alabama at Birmingham's Center for Clinical and Translational Science and the Northwestern University Clinical and Translational Sciences, to its Phase I partners: Mayo Clinic's Center for Clinical and Translational Science and the Louisiana Clinical and Translational Science Center. The Administrative Core will be responsible for managing the administrative, fiscal, and scientific aspects of the MCCTR, including the oversight, marketing, and coordination of all MCCTR cores and activities. The Professional Development Core will offer structured mentorship, training opportunities, and protected research time for early stage investigators at MCCTR partner institutions. The Community Engagement and Outreach Core will provide training and support to investigators in conducting community engaged research; partner with healthcare providers through its new Practice-Based Research Network; and work with its expanded Community Advisory Board to provide bi-directional communication and guidance on community values, concerns, and needs and represent the MCCTR to Mississippi Communities. The Biostatistics, Epidemiology, and Research Design Core will provide training and assistance with research design, data collection and management, and statistical analysis to increase the effectiveness, efficiency, and success of research conducted by MCCTR investigators. The Pilot Projects Program will support clinical, translational, and population-based research projects likely to have a meaningful impact on Mississippi health outcomes and lead to extramural funding. The Research Services Core will support research projects through study coordination and regulatory support and will help connect researchers to communities through expanded telehealth and cohort-study resources. Finally, the Tracking and Evaluation Core will provide accurate and timely information on MCCTR performance and impact to inform planning and implementation by leadership and advisory bodies. Through the infrastructure of resources and personnel developed by MCCTR, Mississippi's health outcomes will be positively impacted.